Precision Strike Strategy for Liver Diseases Trilogy with Xiao-Chai-Hu Decoction: A Meta-Analysis with Machine Learning [0.03%]
小柴胡汤精炼治肝病三篇精准施策： meta分析与机器学习研究
Zexin Wang,Yubing Li,Xiaobao Wang et al.
Zexin Wang et al.
Background and purpose: The progression from hepatitis to liver fibrosis (LF) and ultimately to hepatic carcinoma (HCC) represents the advanced stages of various liver diseases. Currently, no universal treatment effective...
Multiscale insights into cornuside's effects on NAFLD: A cross-disciplinary integrating bioinformatics, computational chemistry, and machine learning [0.03%]
Cornuside对NAFLD作用的多尺度研究：生物信息学、计算化学和机器学习交叉学科整合分析
Gai Gao,Xiaowei Zhang,Zhenzhen Wang et al.
Gai Gao et al.
Background: Non-alcoholic fatty liver disease (NAFLD) is a complex metabolic disorder involving intertwined signaling pathways, posing challenges for targeted therapeutic interventions. Cornus Fructus (CF), a traditional ...
Mori Folium ethanol extracts induce ferroptosis and suppress gastric cancer progression by inhibiting the AKT/GSK3β/NRF2 axis [0.03%]
Mori Folium乙醇提取物通过抑制AKT/GSK3β/NRF2轴诱导铁死亡并抑制胃癌进展
Xin Hu,Hongbo Chang,Yan Guo et al.
Xin Hu et al.
Background: Mori Folium, the leaf of Morus alba L., is a traditional Chinese medicine (TCM) known for its diverse pharmacological activities, including anti-inflammatory and immunomodulatory effects. While the Morus alba ...
Xingxiao pills suppresses lung adenocarcinoma progression by modulating lipid metabolism and inhibiting the PLA2G4A-GLI1-SOX2 Axis [0.03%]
醒消丸通过调节脂质代谢和抑制PLA2G4A-GLI1-SOX2轴来抑制肺腺癌进展
Xueni Fang,JingHua Li,HaoYue Pang et al.
Xueni Fang et al.
Background: Lung adenocarcinoma (LUAD) remains a leading cause of cancer mortality due to resistance, metastasis, and recurrence. Unlike conventional cytotoxic therapies, Xingxiao Pills (XXP), a classic traditional Chines...
Qingshu Yiqi decoction ameliorates exertional heat stroke-induced intestinal barrier injury via NF-κB/MLC pathway and gut microbiota [0.03%]
清暑益气汤通过NF-κB/MLC通路和肠道菌群改善热射病所致小肠屏障损伤作用研究
Weiyi Ma,Man Wang,Jikuai Chen et al.
Weiyi Ma et al.
Background: Exertional heat stroke (EHS) is a life-threatening condition induced by high-temperature environments, which poses significant health risks. The Qingshu Yiqi Decoction (QSYQD) is a traditional Chinese medicine...
Huiyang Shengji decoction promotes healing of diabetic skin ulcers via the NF-κB/STAT3/NLRP3 signaling pathway: A multi-omics analysis [0.03%]
惠阳生肌汤通过NF-κB/STAT3/NLRP3信号通路促进糖尿病皮肤溃疡愈合：多组学分析
Li Lin,Fangning Yu,Xiao Tang et al.
Li Lin et al.
Background: The Huiyang Shengji Decoction (HYSJD) is a renowned compound herbal formula known for its ability to accelerate the healing of chronic wounds, including diabetic skin ulcers(DSU). However, the precise mechanis...
Immunomodulatory mechanism of Huangqi-Guizhi-Wuwu Decoction in alleviating autoimmune arthritis based on network pharmacology and experimental validation [0.03%]
基于网络药理学和实验验证的黄芪桂枝五物汤调控自身免疫性关节炎免疫机制研究
Wenbo Zhang,Ping Wu,Yue Song et al.
Wenbo Zhang et al.
Background: Juvenile idiopathic arthritis (JIA) is the most common type of childhood autoimmune arthritis. Huangqi Guizhi Wuwu decoction (HGWD), a traditional Chinese herbal formula, is widely used in China to treat patie...
Polyphyllin Ⅵ modulates macrophage polarization through autophagy-NLRP3 inflammasome to alleviate inflammatory bowel disease [0.03%]
绞股蓝皂苷VI通过调节自噬-NLRP3炎性小体调控巨噬细胞极化以改善实验性结肠炎
Shuo Yuan,Bao-Hong Liu,Wen-Wen Cheng et al.
Shuo Yuan et al.
Background: Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract with a rising global prevalence. If left untreated, it can result in severe complications, including colon can...
Gluconic acid alleviates hypertrophic scar formation through binding PLOD1, reducing p-AKT signaling and activating autophagy [0.03%]
葡萄糖酸通过结合PLOD1、减少p-AKT信号传导和激活自噬来缓解肥厚性疤痕形成
Jingyun Li,Siqi Zeng,Yue Sun et al.
Jingyun Li et al.
Background: Hypertrophic scarring represents a major clinical challenge worldwide, with current treatment strategies showing limited effectiveness. Gluconic acid (GLA), a naturally occurring glucose metabolite found in fr...
Guiding precision medicine strategy for intravenous ginsenosides via pharmacokinetic-informed bioinformatic approaches: a study on XueShuanTong [0.03%]
基于药代动力学信息的生物信息学方法指导红参皂苷精准医疗策略研究：血栓通注射液的实例分析
Wei-Wei Jia,Nan-Nan Tian,Zi-Jing Song et al.
Wei-Wei Jia et al.
Background: Intravenous ginsenosides, derived from Panax species, are widely used in China. XueShuanTong injection, enriched with ginsenosides Rb1 and Rg1, is recommended for unstable angina treatment. Although effective,...