A novel EndMT inhibitor, xanthotoxin, attenuates non-alcoholic fatty liver disease by acting as TGFβR2 antagonist [0.03%]
新型内皮-间质转化抑制剂白屈菜赤碱通过充当TGFβR2拮抗剂缓解非酒精性脂肪肝病
Xiaona Zhao,Fangjie Xia,Zixu Dong et al.
Xiaona Zhao et al.
Background: Endothelial-to-mesenchymal transition (EndMT) has emerged as a key process contributing to the pathology of non-alcoholic fatty liver disease (NAFLD). Thus, identifying EndMT inhibitors may help impede NAFLD p...
Efficacy of Chinese herbal medicines combined with high-intensity focused ultrasound for patients with uterine fibroids: A meta-analysis with core herbs exploration [0.03%]
中医药联合高强度聚焦超声治疗子宫肌瘤的疗效研究：基于核心药味探索的meta分析
Yu-Ting Huang,Meng-Chun Wang,Jian-An Liao et al.
Yu-Ting Huang et al.
Background: Uterine fibroids (UFs) are prevalent benign tumours affecting women; they often present with symptoms such as excessive menstrual bleeding, pelvic discomfort, recurrent pregnancy loss, and infertility. High-in...
The anti-metastatic effect of elemene in human hepatocellular carcinoma is potentially mediated by inhibiting a novel driver-circBPTF [0.03%]
苍术素通过抑制新型驱动因子circBPTF发挥抗肝癌转移作用
Mengyu Yang,Xiaoyu Chen,Yongqian Liu et al.
Mengyu Yang et al.
Background: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide, with metastasis being one of the primary characteristics. Elemene, a natural product derived from Curcuma wenyujin, has ...
Comprehensive multi-omics and pharmacokinetics reveal sclareol's role in inhibiting ocular neovascularization [0.03%]
全面的多组学和药代动力学揭示了氯雷醇在抑制眼部新生血管化中的作用
Chong-Chao Yang,Qin Jiang,Jin-Song Xue
Chong-Chao Yang
Background: Ocular neovascularization, a hallmark of several vision-threatening diseases, including retinopathy of prematurity (ROP) and wet age-related macular degeneration (wet AMD), is commonly treated with intravitrea...
Nuciferine ameliorates blood-brain barrier disruption post-ischemic stroke via inhibiting the JAK2/STAT3 pathway [0.03%]
异丙化风药通过抑制JAK2/STAT3信号通路改善脑缺血再灌注后血脑屏障的破坏作用
Jiamin Li,Miaomiao Liu,Minglei Fan et al.
Jiamin Li et al.
Background: Ischemic stroke frequently results in the compromise of the blood-brain barrier (BBB), a pathological occurrence strongly linked to the impairment of cerebral microvascular endothelial cells and the disintegra...
Verbenalin protects against coronavirus pneumonia by promoting host immune homeostasis: Evidences for its mechanism of action [0.03%]
藤黄酸通过促进宿主免疫稳态防治冠状病毒肺炎：作用机制证据
Qiyue Sun,Ronghua Zhao,Shuran Li et al.
Qiyue Sun et al.
Background: Coronavirus has caused high-mortality viral pneumonia worldwide. The pathogenesis is characterized by hyperinflammatory reactions resulting from immune homeostasis dysregulation. Verbenalin, an iridoid glucosi...
Helja lectin inhibits Candida albicans phagocytosis and induces pro-inflammatory responses in dendritic cells [0.03%]
Helja凝集素抑制白色念珠菌吞噬并诱导树突状细胞促炎症反应
Maia Chop,Marianela Del Rio,Melisa B Radicioni et al.
Maia Chop et al.
Background: Plant lectins have gained attention for their antimicrobial and immunomodulatory properties and potential therapeutic applications in controlling infectious diseases and inflammatory disorders. ...
Calceolarioside B targets MMP12 in the tumor microenvironment to inhibit M2 macrophage polarization and suppress hepatocellular carcinoma progression [0.03%]
Calceolarioside B通过靶向肿瘤微环境中的MMP12抑制M2型巨噬细胞极化并抑制肝癌进展
Linna Cao,Miaomiao Shao,Yifei Gu et al.
Linna Cao et al.
Background: Tumor-associated macrophages (TAMs) are crucial in hepatocellular carcinoma (HCC) progression and prognosis, making them promising immunotherapy targets. In traditional Chinese medicine (TCM), qi stagnation an...
Pae/exo@PF-127 promote diabetic wound healing through miR-424-5p [0.03%]
PAE/exo@PF-127通过miR-424-5p促进糖尿病创面修复
Yidan Xia,Beibei Han,Fengyuan Zhang et al.
Yidan Xia et al.
Background: Currently, chronic diabetic wound healing is one of the urgent clinical challenges. Choosing appropriate dressings loaded with stem cell-derived exosomes (exo) and traditional Chinese medicine extracts that pr...
Oligomeric proanthocyanidin attenuates asthma severity and airway remodeling by modulating epithelial-smooth muscle cell interactions [0.03%]
寡聚原花青素通过调节上皮-平滑肌细胞相互作用缓解哮喘严重程度和气道重塑
Shengwei Gu,Yihang Gu,Hao Gu et al.
Shengwei Gu et al.
Background: As a significant instigator of asthma pathogenesis, the airway epithelium produces cytokines that disrupt lung homeostasis and contribute to airway remodeling. Although efforts are directed in the management o...