Valtrate alleviates inflammation by targeting USP9X to enhance NLRP3 degradation [0.03%]
_VALTRATE通过靶向USP9X促进NLRP3降解从而减轻炎症
Kaiyue Su,Neng Ye,Lei Lin et al.
Kaiyue Su et al.
Background: The NLRP3 inflammasome is a key regulator of innate immunity and plays a critical role in the pathogenesis of various inflammatory diseases. Regulating NLRP3 has emerged as a promising strategy for the develop...
Pentagalloyl glucose targets the JAK1/JAK3-STAT3 pathway to inhibit cancer stem cells and epithelial-mesenchymal transition in 5-fluorouracil-resistant colorectal cancer [0.03%]
五氟尿嘧啶耐药性结直肠癌中棓酰葡萄糖靶向JAK1/JAK3-STAT3通路抑制癌症干细胞和上皮间质转化
Chengli Wen,Xu Zhang,Jiraporn Kantapan et al.
Chengli Wen et al.
Background: Colorectal cancer (CRC) resistance to 5-fluorouracil (5-FU), primarily driven by cancer stem cells (CSCs) and epithelial-mesenchymal transition (EMT), remains a major clinical challenge, necessitating novel th...
Corrigendum to "Anemoside B4 targets NEK7 to inhibit NLRP3 inflammasome activation and alleviate MSU-induced acute gouty arthritis by modulating the NF-κB signaling pathway" [Phytomedicine Volume 138 (2025) 156407] [0.03%]
“风药素B4靶向NEK7抑制NLRP3炎性小体激活并调节NF-κB信号通路缓解尿酸诱导的急性痛风性关节炎”一文的勘误[Phytomedicine卷138（2025）156407]
Xinghua Ni,Qinqin Wang,Yujie Ning et al.
Xinghua Ni et al.
Modulation of Sirtuins to address aging related disorders through the use of selected phytochemicals [0.03%]
利用选择的植物化学物质调节Sirtuins以应对与衰老相关疾病的研究进展
Jing Wang,Yaoyao Ren,Shengtao Qu
Jing Wang
Background: Aging is a complex phenomenon involving oxidative stress, inflammation, and cellular damage subsequently leading to various disorders, such as cardiovascular diseases, neurodegenerative disorders, diabetes, an...
Immunomodulatory activity of bamboo biosilica from Dendrocalamus longispathus Kurz. - Metabolomics integrated network pharmacology approach [0.03%]
基于代谢组学的网络药理学研究竹柯石炭对免疫调节作用成分及机制探讨
Amit Kar,Sayan Biswas,Barun Das Gupta et al.
Amit Kar et al.
Background: Bamboo has been used in traditional Asian medicine since ancient times. Silica is formed in the shoot internodes of various bamboo species. This bamboo-derived silica, referred to as bamboo biosilica or "bansl...
Halofuginone targets Serine/Glycine synthesis to reverse epidermal growth factor receptor Tyrosine Kinase inhibitor resistance in lung adenocarcinoma [0.03%]
卤氟宁通过靶向丝氨酸/甘氨酸合成逆转肺腺癌表皮生长因子受体酪氨酸激酶抑制剂耐药性
Yongping Li,Peipei Liu,Shiyao Liu et al.
Yongping Li et al.
Background: An emerging issue is that patients are prone to become resistance to epidermal growth factor tyrosine kinase inhibitors (EGFR-TKIs) which are the first- line treatment for EGFR-mutated non-small cell lung canc...
The potential therapeutic effects of Panax notoginseng in osteoporosis: A comprehensive review [0.03%]
南美人参在骨质疏松症中的潜在治疗效果：综述
Zijun Zhu,Zhenyu Bai,Yan Cui et al.
Zijun Zhu et al.
Background: Accumulating evidence shows that Panax notoginseng, a well-known medicinal herb, has an ideal effect on prevention and treatment of skeletal diseases. In this study, we reviewed clinical applications of clinic...
Platycodonis radix polysaccharides suppress progression of high-fat-induced obesity through modulation of intestinal microbiota and metabolites [0.03%]
Platycodonis radix 多糖通过调节肠道微生物群和代谢物抑制高脂诱导的肥胖进展
Nannan Zhi,Xiangwei Chang,Liangping Zha et al.
Nannan Zhi et al.
Background: Obesity is a prevalent chronic condition worldwide, posing a significant risk to public health. Polysaccharides derived from Platycodonis Radix (PR) have been identified as the primary bioactive compounds in c...
Bioactive equivalent combinatorial components of Xiao-Xu-Ming decoction inhibit the calmodulin-mediated MLCK/MLC axis to attenuate coronary artery spasm [0.03%]
小ₓ Xu Ming汤生物活性等效复方成分通过抑制钙调蛋白介导的肌球蛋白轻链激酶/肌球蛋白轻链轴缓解冠脉痉挛
Bowen Wu,Mishan Wu,Peiyu Yan
Bowen Wu
Background: Coronary artery spasm (CAS) is a severe pathological disorder with limited treatment options. Inhibiting vascular smooth muscle cell (VSMC) proliferation has emerged as a promising therapeutic strategy for CAS...
Lingguizhugan decoction inhibit pulmonary hypertension by regulating macrophage IL-6 secretion via IL-33/ST2 pathway [0.03%]
灵龟祝嘏膏通过IL-33/ST2信号通路调节巨噬细胞分泌IL-6抑制肺动脉高压
Zhengwei Dong,Zhifeng Xue,Min Zhang et al.
Zhengwei Dong et al.
Background: Lingguizhugan decoction (LGZG), a typical Chinese herbal formula, has remarkable clinical effects for treating pulmonary hypertension (PH) with unclear ingredients and mechanisms. This study aimed to evaluate ...