Sihe Tufuling formula alleviates imiquimod-induced psoriasis-like skin lesions in mice by modulating the HIF-1 signaling pathway [0.03%]
西河毒肤灵方通过调节缺氧诱导因子-1信号通路治疗小鼠类银屑病皮损
Yutong Kang,Abudureyimu Alimujiang,Fan Zhou et al.
Yutong Kang et al.
Objective: Psoriasis is a chronic, immune-mediated dermatological disorder characterized by pathological epidermal hyperplasia, aberrant keratinocyte differentiation, and dermal infiltration of inflammatory cells. Sihe Tu...
JianPi QingRe HuoXue Formula targets Cadherin-17 to induce apoptosis in chronic atrophic gastritis with intestinal metaplasia [0.03%]
健脾清热活血方通过靶向CDH17诱导萎缩性胃炎肠化生的细胞凋亡
Zihan Mai,Yiyuan Zheng,Jiali Xie et al.
Zihan Mai et al.
Background: Chronic atrophic gastritis (CAG) with intestinal metaplasia (IM) constitutes a critical intermediate stage in the progression from chronic non-atrophic gastritis (CNAG) to intestinal-type gastric cancer (GC), ...
Dingxin Recipe III resolves atherosclerotic inflammation via revitalizing Regulatory T cell lineage fidelity associated with fatty acid oxidation metabolic reprogramming [0.03%]
Dingxin方第三剂通过促进调节性T细胞谱系忠实性和与脂肪酸氧化代谢重构相关的作用来缓解动脉粥样硬化炎症
Xiao Li,Yuanyu Tu,Yao Jin et al.
Xiao Li et al.
Background: Atherosclerosis is fundamentally a pathology of unresolved inflammation perpetuated by the collapse of Regulatory T cell (Treg)-mediated tolerance. Emerging evidence indicates that Treg functional integrity is...
Compound Kushen injection improves M1 macrophage polarisation and radiation-induced colitis by regulating Piezo1-mediated NF-κB/NLRP3 pathway [0.03%]
复方苦参注射液通过调节Piezo1介导的NF-κB/NLRP3信号通路改善M1型巨噬细胞极化和放射性结肠炎
Xin Sun,Zheng Li,Shangfei Luo et al.
Xin Sun et al.
Background: Radiation-induced colitis (RIC) is a common complication following radiotherapy for pelvic and abdominal malignancies. Dysregulated polarisation of macrophages towards the pro-inflammatory classically activate...
Indirubin suppresses ovarian cancer progression by inhibiting PI3K/AKT-mediated EMT and tumor growth without systemic toxicity [0.03%]
吲哚酚通过抑制PI3K/AKT介导的上皮间质转化和肿瘤生长来抑制卵巢癌的发展而不产生系统性毒性
Qiaomei Zheng,Xia Zhang,Shaozhan Chen et al.
Qiaomei Zheng et al.
Purpose: This study investigated indirubin's effects on ovarian cancer cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT), both in vitro and in vivo, while exploring its underlying mechan...
Asperosaponin VI delays the progression of facet joint osteoarthritis by promoting mitophagy, inhibiting the cGAS/STING pathway, and attenuating chondrocyte pyroptosis [0.03%]
asperosaponin Ⅵ通过促进线粒体自噬、抑制cGAS/STING信号通路及减轻软骨细胞焦亡来延缓椎间关节骨关节炎的进展
Shuang Chen,Fei Hu,Nan Wang et al.
Shuang Chen et al.
Background: Facet joint osteoarthritis (FJOA) is increasingly recognized as a key pathological contributor to low back pain, but effective treatment strategies remain elusive. Asperosaponin VI (ASA VI) exhibits significan...
Huaier-derived arnicolide D induces ferroptosis in gastric cancer via SRC/TNF-mediated GPX4 inactivation [0.03%]
华蟾素衍生的arnicolide D通过SRC/TNF介导的GPX4失活诱导胃癌细胞铁死亡
Jiaxuan Liu,Xinuo Zhang,Yunfu Shi et al.
Jiaxuan Liu et al.
Background: While ferroptosis induction has emerged as a promising strategy against gastric cancer (GC), clinically viable natural inducers remain scarce. Huaier n-butanol extract (HBE), a crude extract derived from the t...
Flavonoids of Ziziphora clinopodioides improve Alzheimer's cognitive impairment and inhibit NLRP3 inflammasome activation via autophagy-lysosome pathway [0.03%]
皱皮酸模素黄酮通过自噬溶酶体途径改善阿尔茨海默病认知障碍及抑制NLRP3炎性小体激活作用研究
Lili Gu,Jiayi Liu,Xiaoqin Shan et al.
Lili Gu et al.
Background: Ziziphora clinopodioides Lam. (Z. clinopodioides), a distinctive medicinal plant endemic to Xinjiang, is predominantly centers on cardiovascular diseases. However, its possible therapeutic value in neurologic ...
Indole-3-carbinol attenuates cisplatin-induced premature ovarian failure by activating Nrf2 through competitive binding of Keap1 [0.03%]
_indole-3-甲醛通过与Keap1竞争性结合激活Nrf2来缓解顺铂诱导的卵巢早衰
Fengyu Zhu,Ruixin Zhang,Zhuoying He et al.
Fengyu Zhu et al.
Background: Premature ovarian failure (POF) leads to female infertility and significantly increases long-term health risks. However, available drugs that can reverse this condition are lacking. ...
Resveratrol combats Salmonella infection via liberating vacuole-enclosed bacteria for enhanced autophagic clearance and blocking HMGA2-mediated G2/M arrest [0.03%]
白藜芦醇通过促进自噬清除包裹在囊泡中的沙门氏菌并抑制HMGA2介导的G2/M期阻滞来对抗沙门氏菌感染
Jiayang Liu,Xueyu Li,Jinli Ge et al.
Jiayang Liu et al.
The escalating crisis of antimicrobial resistance necessitates a paradigm shift toward host-directed therapies (HDTs) that circumvent pathogen evasion strategies. Here we show that the natural polyphenol resveratrol clears intracellular Sal...