Sesamin ameliorates ulcerative colitis by modulating the DUSP1/ERK feedback loop and restoring gut microbiota homeostasis [0.03%]
芝麻素通过调节DUSP1/ERK反馈环并恢复肠道菌群稳态来改善溃疡性结肠炎
Shuxia Cao,Xiangyu Guo,Mengyuan Xin et al.
Shuxia Cao et al.
Background: Sesamin (SSM), a plant-derived lignan, possesses anti-inflammatory and immunomodulatory effects. The pathogenesis of ulcerative colitis (UC) is complex and involves intestinal mucosal damage, inflammation, and...
Huaier overcomes tumor-induced immunosuppression in colorectal cancer by activating MHC I and CD8+ T cells [0.03%]
华蟾素通过激活MHC I和CD8+T细胞克服结直肠癌肿瘤源性免疫抑制作用
Jiayu Chen,Yuxue Li,Qingyang Sun et al.
Jiayu Chen et al.
Background: Colorectal cancer (CRC) remains a leading cause of cancer-related mortality, primarily due to its immunosuppressive microenvironment that facilitates immune evasion and resistance to therapy. Although the trad...
Mechanisms of action of traditional Chinese medicine in the treatment of myocardial injury: A comprehensive review [0.03%]
中医药治疗心肌损伤的机制研究：综述
Lu-Ying Zhang,Hao-Yuan Yin,Xiang-Zhun Song et al.
Lu-Ying Zhang et al.
Background: Myocardial Injury (MI) is a condition in which there is an adverse reaction to the function of the heart, which can seriously damage health in some severe cases, producing symptoms such as shock and sudden dea...
Protection against stroke-induced blood-brain barrier disruption by Guanxinning injection and its active-component combination via TLR4/NF-κB/MMP9-mediated neuroinflammation [0.03%]
通过TLR4/NF-κB/MMP9介导的神经炎症保护冠心宁注射液及其有效组分配伍对抗脑卒中所致的血脑屏障破坏作用
Siwen Fan,Hongying Du,Yixin Yao et al.
Siwen Fan et al.
Background: The blood-brain barrier (BBB) is essential for central nervous system (CNS) homeostasis, yet neuroinflammatory mechanisms driving BBB disruption remain poorly understood. ...
Mechanistic insights into baicalein's anti-inflammatory effects in COPD: Targeting oxidative stress and CD8⁺ T cell cytotoxicity [0.03%]
黄芩素在慢性阻塞性肺疾病中的抗炎机制研究：针对氧化应激和CD8⁺T细胞毒性作用
Xinru Xiao,Wenwen Guo,Ziqi Ding et al.
Xinru Xiao et al.
Background: Chronic obstructive pulmonary disease (COPD) is defined by chronic airway inflammation. Traditional Chinese herb Pinellia ternata is used to treat COPD, but its bioactive components and mechanisms are uncl...
Colchicine alleviates atherosclerosis combined with diabetes mellitus by targeting PIM2 and regulating the NF-κB signaling pathway [0.03%]
秋水仙碱通过靶向PIM2和调节NF-κB信号通路来缓解动脉粥样硬化合并糖尿病
Haiming Wang,Wenhao Feng,Jing Wang et al.
Haiming Wang et al.
Background: Coronary heart disease (CHD) is becoming increasingly prevalent worldwide due to the aging population. Although diabetes mellitus (DM) is an independent risk factor for the development of CHD, existing anti-at...
Salvigenin mitigates neuronal ferroptosis by binding to PI3K and enhancing the interaction between VCP and PI3K in the repair of spinal cord injury [0.03%]
salvigenin通过与PI3K结合并增强VCP和PI3K之间的相互作用来缓解神经元铁死亡以修复脊髓损伤
Youyang Yu,Xinsheng Xie,Yu Zhang et al.
Youyang Yu et al.
Background: Spinal cord injury (SCI) represents a major public health issue, characterized by the excessive production of lipid reactive oxygen species (ROS), iron accumulation, and lipid peroxidation within the injured s...
Co-administration of berberine and evodiamine: Mitigating evodiamine-induced hepatotoxicity and potentiating colitis treatment [0.03%]
小檗碱与吴茱萸碱联用：缓解吴茱萸碱致肝毒性及协同治疗结肠炎
Xiaoyu Tao,Yifei Gao,Zhengsen Jin et al.
Xiaoyu Tao et al.
Background: The combined therapeutic mechanisms of evodiamine (EVO) and berberine (BBR), which are the primary bioactive components contributing to the pharmacological effects of Euodiae Fructus and Rhizoma Coptidis, a cl...
Fibroblast activation protein-α drives rheumatoid arthritis inflammation through the AKT/mTOR signaling pathway and its therapeutic effect by Wangbi granules [0.03%]
纤维激活蛋白-α通过AKT/mTOR信号通路驱动类风湿关节炎炎症及王痹颗粒的治疗作用
Zihan Wang,Qiumei Dong,Liubo Zhang et al.
Zihan Wang et al.
Background: Fibroblast activation protein-α (FAPα), a transmembrane protein highly expressed in rheumatoid arthritis (RA) synovium, is postulated to drive inflammatory cascades, yet its mechanistic role remains elusive....
Schisandra chinensis mixture attenuates diabetic kidney disease via VDAC1/Grp75/IP3R-mediated MAMs stabilization and apoptosis-autophagy regulation [0.03%]
五味子混合物通过VDAC1/Grp75/IP3R介导的MAM稳定和凋亡-自噬调节来缓解糖尿病肾病
Hongdian Li,Ao Dong,Cong Liu et al.
Hongdian Li et al.
Background: Diabetic kidney disease (DKD) is a major cause of end-stage renal disease, with mitochondrial dysfunction-mediated tubular injury implicated in its pathogenesis. Mitochondria-associated membranes (MAMs) coordi...