Gardeniae Fructus extract terminates refractory status epilepticus with a wide time window through inhibiting neuroinflammation [0.03%]
番石榴叶提取物可通过抑制神经炎症终止难治性状态癫痫发作且具有广泛的时间窗口
Minjuan Sun,Zhijian Yuan,Menghan Li et al.
Minjuan Sun et al.
Background: Status epilepticus (SE) is the most severe epilepsy type and exhibits a high resistance rate to the first-line therapy diazepam (DZP), which terms as refractory SE. Activated neuroinflammation is a key factor ...
Ophiopogonin C protects against acute lung injury by fatal sepsis through pyroptosis macrophage [0.03%]
天冬素C通过焦亡型巨噬细胞保护内毒素致死性脓毒症诱导的急性肺损伤作用研究
WeiWei Zhang,Hui Yang,Bangzhi Sui et al.
WeiWei Zhang et al.
Background: Sepsis is a frequent complication of severe infection and trauma, and one of the common causes of acute lung injury (ALI). Macrophage pyroptosis plays an important role in sepsis-induced ALI, takes part in the...
Mechanisms of LouDan LiFei granule attenuate inflammatory injury in AECOPD:A network pharmacology and experimental validation [0.03%]
络丹苈菲颗粒防治慢性阻塞性肺疾病急性加重炎症损伤的网络药理学及实验验证
Jing Guo,Lin-Shui Zhou,Xin Lv et al.
Jing Guo et al.
Background: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) significantly contributes to the high mortality rate associated with chronic obstructive pulmonary disease (COPD). It leads to a decline in ...
Therapeutic potential of Platycodin D in allergic asthma through anti-inflammatory and anti-remodeling effects [0.03%]
北豆根皂苷 platycodin d 抗炎和抗重塑治疗过敏性哮喘的潜力
Li Chen,Jianwei Feng,Guina Wang et al.
Li Chen et al.
Background: Allergic asthma (AA) is a prevalent chronic respiratory disease characterized by airway hyperresponsiveness (AHR) and chronic inflammation, significantly impairing patients' quality of life. ...
Sophocarpine suppresses MAPK-mediated inflammation by restoring gut microbiota in colorectal cancer [0.03%]
Sophocarpine通过恢复肠道微生物群介导MAPK信号通路抑制结直肠癌炎症作用
Xiangjun Liu,Yu Li,Chenyue Yuan et al.
Xiangjun Liu et al.
Background: Colorectal cancer (CRC), as one of the most common cancers globally, poses a significant challenge to public health due to its high incidence and mortality rates. This underscores the need for continuous explo...
Evodiamine inhibits NLRP3 inflammasome-mediated microglial pyroptosis and promotes remyelination via SLC2A4-regulated autophagy [0.03%]
吴茱萸碱通过调节SLC2A4调控的自噬抑制NLRP3炎性小体介导的微胶质细胞细胞焦亡并促进少突胶质细胞源性神经干细胞类器官中髓鞘修复的作用及机制研究
Yunjie Zhao,Xingzong Sun,Faling Shao et al.
Yunjie Zhao et al.
Background: Activation of the NLRP3 inflammasome triggers pyroptosis, a pro-inflammatory type of cell death, in multiple sclerosis (MS). Evodiamine (EVO) possesses anti-inflammatory and neuroprotective properties; however...
Traditional Chinese medicine in cerebral infarction: Integrative strategies and future directions [0.03%]
中医治疗脑梗死：整合策略与未来方向
Wenhao Ouyang,Zekang Deng,Yudi Li et al.
Wenhao Ouyang et al.
Background: Cerebral infarction is a predominant cause of global disability and mortality, characterized by pathogenesis that includes vascular stenosis, thrombosis, ischemic necrosis, and neuroinflammation. Despite progr...
Refined qingkailing attenuates reactive astrocytes and glial scar formation after ischemia stroke via the EGFR/PLCγ pathway [0.03%]
精制清开灵通过EGFR/PLCγ途径减轻缺血性卒中后的星形胶质细胞活化和胶质瘢痕形成
Zi-Lin Ren,Chu-Xin Zhang,Yu-Xiao Zheng et al.
Zi-Lin Ren et al.
Background: Ischemic stroke (IS) is the main cause of disability worldwide, and glial scar can impair neurological recovery during the post-stroke period. Refined qingkailing (RQKL) has been demonstrated to be neuroprotec...
Palmitic acid enhances the sensitivity of ferroptosis via endoplasmic reticulum stress mediated the ATF4/TXNIP Axis in polycystic ovary syndrome [0.03%]
棕榈酸通过内质网应激介导的ATF4/TXNIP轴增强多囊卵巢综合征铁死亡的敏感性
Xumin Zhang,Jianrong Liu,Chunmei Bai et al.
Xumin Zhang et al.
Background: Palmitic acid (PA), the most prevalent saturated fatty acid in humans, is closely associated with ovarian dysfunction. Elevated PA levels in the follicular fluid of patients with polycystic ovary syndrome (PCO...
Saikosaponin A targets HDAC6 to inhibit Mycobacterium tuberculosis-induced macrophage Pyroptosis via autophagy-mediated NLRP3 inflammasome inactivation [0.03%]
甘草甜素A通过自噬介导的NLRP3炎性小体失活抑制分枝杆菌诱导的小胶质细胞焦亡作用于HDAC6
Fanglin Liu,Jianchao Wu,Jingjing Shen et al.
Fanglin Liu et al.
Background: Mycobacterium tuberculosis (Mtb) is among the oldest and most resilient human pathogens, remaining a major global public health threat. Its characteristic pathological features include granuloma formation and ...