Lingguizhugan decoction inhibits the cleavage of LYVE-1 by MMP-9 and promotes lymphangiogenesis to improve myocardial infarction [0.03%]
苓桂术甘汤通过抑制MMP-9介导的LYVE-1裂解促进淋巴管新生以改善心肌梗死
Liding Bai,Jiaxin Li,Siqi Du et al.
Liding Bai et al.
Background: Myocardial remodeling plays a crucial role in determining patient outcomes after myocardial infarction (MI). Emerging evidence from both preclinical and clinical studies highlights the beneficial effects of ca...
Terrestrosin D promotes autophagy and apoptosis of breast cancer cells through PSMD1-dependent activation of P53 pathway [0.03%]
Terrestrosin D通过PSMD1依赖的P53途径活化促进乳腺癌细胞自噬和凋亡
Li-Ling Jia,Chen-Jie Wu,Pei-Wen Ye et al.
Li-Ling Jia et al.
Background and purpose: Breast cancer, particularly triple-negative breast cancer (TNBC), poses a significant threat to women's health. In tumor cells, autophagy and apoptosis are double-edged swords, playing complex role...
Hedyotis chrysotricha aqueous extract inhibits hepatitis B surface antigen and viral replication via hepatocyte nuclear factor 4α regulation [0.03%]
喉毛花素抑制肝细胞核因子4α调控的乙型肝炎表面抗原和病毒复制作用
Yina Yu,Haoyang Hu,Yichun Zhang et al.
Yina Yu et al.
Background: Chronic hepatitis B virus (HBV) infection continues to pose a significant global public health challenge, as current antiviral treatments have not yet succeeded in completely eradicating the virus. Traditional...
Brevilin A, a novel BNIP3 inhibitor suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss via impairing mitophagy and mitochondrial metabolism [0.03%]
新型BNIP3抑制剂bretilin A通过干扰线粒体自噬和代谢抑制破骨细胞生成并预防卵巢切除引起的骨质流失
Rui Zhou,Yiyuan Wang,Siyi Liu et al.
Rui Zhou et al.
Background: The mitochondrial dysfunction and overactive osteoclasts is involved in the progress of osteoporosis. Brevilin A (BA), a sesquiterpene lactone, is a compound extracted and purified from Centipeda minima. It ex...
18β-glycyrrhetinic acid mitigates lipotoxicity-induced premature senescence of tubular epithelial cells by activating SIRT1-TFEB signaling [0.03%]
甘草次酸通过激活SIRT1-TFEB信号通路缓解脂毒性诱导的肾小管上皮细胞衰老
Meng Yang,Weihong Qin,Qihui Dai et al.
Meng Yang et al.
Background: Targeting metabolic disorders has emerged as a promising therapeutic strategy in the treatment of chronic kidney disease (CKD). 18β-glycyrrhetinic acid (18β-GA) is known for its metabolic regulatory and anti...
Neuroprotective effects of Gastrodia elata and its compounds in a Caenorhabditis elegans Alzheimer's disease model [0.03%]
天麻及其化合物在模式生物秀丽线虫阿尔茨海默病模型中的神经保护作用研究
Yanqing Zhang,Xiaotong Zhao,Li Gong et al.
Yanqing Zhang et al.
Background: Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by learning and memory impairments, primarily caused by excessive β-amyloid protein (Aβ) accumulation, which induces neuroto...
Quercetin ameliorates hyperuricemic nephropathy through improving gut dysfunctions and decreasing gut bacteria-derived uremic toxins [0.03%]
芸香素通过改善肠道功能障碍和减少细菌产生尿毒症毒素来缓解高尿酸性肾病
Baizhao Peng,Jiaojiao Dai,Shuai Ji et al.
Baizhao Peng et al.
Background: Hyperuricemia (HUA) is closely associated with gut dysbiosis, yet the role of microbial metabolism in hyperuricemic nephropathy (HN) remains poorly understood. Quercetin has shown urate-lowering and nephroprot...
Transcriptomics sequencing reveals Qu-shi-yu-fa Decoction promotes hair cycle and keratinization by upregulating FOXN1 and TGM3 to treat androgenetic alopecia [0.03%]
转录组测序揭示祛脂玉肤汤通过上调FOXN1和TGM3促进毛发生长周期及角蛋白化治疗雄激素性脱发
Mingxi Zhu,Yuan Fang,Ying Huang et al.
Mingxi Zhu et al.
Backgroud: As a prevalent type of hair loss, androgenetic alopecia (AGA) is complex due to the interplay of multiple factors, which has led to a long-standing exploration gap in the field of drug treatment. Qu-shi-yu-fa D...
Lonicerin targets ADRA1D and RSPO3 to ameliorate diabetes-induced vascular injury through Ca2+/Calcineurin/NFAT1-dependent anti-EndMT pathway [0.03%]
_lonicerin通过Ca2+/calcineurin/nfat1依赖性抗endmt通路靶向adra1d和rspo3改善糖尿病引起的血管损伤
Minghui Wang,Huiying Cai,Manman Wang et al.
Minghui Wang et al.
Background: Cardiovascular complications are the primary cause of mortality and disability among diabetic patients. Lonicerin, a major bioactive compound in Lonicera japonica Thunb., has unclear effects and mechanisms on ...
Jian-pi Qu-tan Hua-yu Decoction improves oxidative stress-induced inflammation in endothelial cells in atherosclerotic ApoE-/- mice through the NOX1-ROS-ERK1/2 pathway [0.03%]
健脾祛痰化瘀方通过NOX1-ROS-ERK1/2信号通路改善氧化应激诱导的动脉粥样硬化Apoe基因敲除小鼠内皮细胞炎症作用机制研究
De Zhao Kong,Xue Zhi Zhang,Yi Lu et al.
De Zhao Kong et al.
Background: Atherosclerosis (AS) is a key mechanism in cardiovascular diseases and a major target for interventions. Jian-pi Qu-tan Hua-yu Decoction (JPQTHYD), a herbal formula, has been shown to alleviate AS. ...