Saikosaponin A ameliorates ulcerative colitis by targeting the CH25H/25-OHC axis to inhibit NLRP3 inflammasome in macrophages [0.03%]
补骨脂异黄酮通过靶向CH25H/25-OHC轴抑制巨噬细胞中NLRP3炎性小体治疗溃疡性结肠炎
Xue Yang,Jinni Yang,Anhui Wang et al.
Xue Yang et al.
Background: Ulcerative colitis (UC) has demonstrated an escalating global incidence and prevalence, thereby posing substantial challenges to public health. Despite recent advancements in therapeutic interventions, the cli...
Pectolinarigenin mitigates 5-FU-induced intestinal mucositis via suppressing ferroptosis through activating PPARγ/GPX4 signaling [0.03%]
pektolinaringenin通过激活PPARγ / GPX4信号抑制铁死亡来缓解5-氟尿嘧啶诱导的肠黏膜炎
Xin Ge,Yi-Zhe Fan,Yanyan Deng et al.
Xin Ge et al.
Background: 5-Fluorouracil (5-FU), one of the mostly commonly used chemotherapeutic agents, frequently induces intestinal mucositis, severely impacting patient quality of life and limiting treatment efficacy. Pectolinarig...
Curzerene suppresses epithelial-mesenchymal transition in gastric precancerous lesion cells through targeted regulation of YAP via the long non-coding RNA AFAP1-AS1 [0.03%]
库尔策瑞通过长链非编码RNA AFAP1-AS1靶向调控YAP来抑制胃癌前病变细胞的上皮间质转化
XiaoMing Zhou,ChenXi Zhang,Wen Shen et al.
XiaoMing Zhou et al.
Background: Curzerene, a bioactive compound from Curcuma zedoaria, exhibits anticancer effects, but its role in gastric precancerous lesions remains poorly understood. This study investigates the potential of Curzerene in...
Sophora compounds against non-small cell lung cancer: Research status and mechanisms [0.03%]
Sophora抗非小细胞肺癌的研究进展及机制探讨
Baibai Ye,Cheng Lin,Hao Huang et al.
Baibai Ye et al.
Background: Non-small cell lung cancer (NSCLC) is the most prevalent form of lung cancer, characterized by dysregulated signaling pathways. Many Sophora compounds exhibit potential anti-NSCLC properties. However, the rese...
Corrigendum to "KAJF alleviated colorectal cancer liver metastasis by reshaping the gut microbiota and inhibiting M2-like macrophage polarization" [Phytomedicine, 142(2025) 156766] [0.03%]
“ KAJF通过重塑肠道菌群和抑制M2型巨噬细胞极化来缓解结直肠癌肝转移”的勘误页 [Phytomedicine，142（2025）156766]
Zongmei Zheng,Yizhao Du,Hua Jiang et al.
Zongmei Zheng et al.
Genkwanin impairs triple-negative breast cancer aggressiveness and metastasis by targeting Lysine Demethylase 4C [0.03%]
甘奎宁通过靶向赖氨酸去甲基转移酶4C抑制三阴性乳腺癌的侵袭和转移
Hanfeng Xu,Jie Gao,Shiyong Fu et al.
Hanfeng Xu et al.
Background: Triple-negative breast cancer, the most aggressive breast cancer with highest metastatic capacity and the worst prognosis, accounts for 15 % of breast cancer. According to prior studies, the natural active com...
Changdiqing decoction (CDQD) ameliorates colitis via suppressing inflammatory macrophage activation and modulating gut microbiota [0.03%]
昌地青汤剂通过抑制炎症型巨噬细胞活化及调节肠道菌群改善结肠炎
Zelong Lin,Jun Wang,Huishan Luo et al.
Zelong Lin et al.
Background: Ulcerative colitis (UC) is a non-specific inflammatory bowel disease. Unlike any single form of cell death reported previously, macrophage PANoptosis, a unique programmed cell death characterized by inflammati...
Qing-Fei-Pai-Du-Tang ameliorates lipopolysaccharide-induced rat acute lung injury through attenuating pulmonary microcirculatory disturbances via multi-target regulation [0.03%]
清肺败毒汤通过多靶标作用改善脂多糖诱导的大鼠急性肺损伤的作用机制研究：对肺微循环障碍的干预效应
Shu-Ya He,Chun-Shui Pan,Li Yan et al.
Shu-Ya He et al.
Background: Acute lung injury (ALI) rapidly progressing into acute respiratory distress syndrome (ARDS) is a major cause of the high fatality rate in acute respiratory infectious diseases. Qing-Fei-Pai-Du-Tang (QFPDT) has...
Natural diterpenoids in dermatology: Multifunctional roles and therapeutic potential for skin diseases [0.03%]
天然二萜类化合物在皮肤病学中的多功能作用及治疗潜力
Chunlin Li,Minghua Ma,Xin Liu et al.
Chunlin Li et al.
Background: Skin disorders are a collection of prevalent and frequent illnesses that have significant impacts on daily life. Currently, a limited number of effective therapeutic drugs are available that fall far short of ...
Picropodophyllin induces ferroptosis via blockage of AKT/NRF2/SLC7A11 and AKT/NRF2/SLC40A1 axes in hepatocellular carcinoma as a natural IGF1R inhibitor [0.03%]
小石南茋通过抑制AKT/NRF2/SLC7A11和AKT/NRF2/SLC40A1轴诱导肝癌细胞铁死亡作为天然IGF1R抑制剂
Jiahui Zheng,Yixin Liu,Fengchi Zhu et al.
Jiahui Zheng et al.
Background: Ferroptosis represents a distinct form of regulated cell death characterized by intracellular iron overload and extensive lipid peroxidation. Targeting ferroptosis-related signaling pathways and inducing ferro...