Protective effects of Ginkgo biloba supplementation on clinical outcomes in metabolic dysfunction-associated steatotic liver disease [0.03%]
补益作用于代谢功能障碍相关性肝脂肪变的防护效果
Tom Ryu,Beom Sun Chung,Jaejun Lee et al.
Tom Ryu et al.
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing global health concern linked to increased risks of cardiovascular disease, chronic kidney disease (CKD), and premature mortality. G...
Network pharmacology and in-depth blood proteomics reveal the mechanism of Buqi Tongluo capsules in treating bone destruction in osteoarthritis [0.03%]
基于补气通络胶囊治疗骨关节炎骨破坏作用的网络药理学及深入血清蛋白质组学研究
Haishan Li,Jiasheng Yang,Wei Deng et al.
Haishan Li et al.
Background: Osteoarthritis (OA) is the most prevalent form of arthritis, characterized by a rapidly increasing global incidence. Once OA develops, it initiates an irreversible process of bone destruction, which can lead t...
Ginsenoside Rg1 alleviates cognitive impairment in vascular dementia by modulating Adcy1/Kdr-mediated cholinergic synapse and PI3K-AKT pathway [0.03%]
红参皂苷Rg1通过调节腺苷酸 cyclase 1/血管内皮生长因子受体介导的胆碱能突触和磷脂酰肌醇信号通路治疗血管性痴呆中的认知障碍
Yuheng Wang,Xiaolu Wei,Huijun Wang et al.
Yuheng Wang et al.
Background: Vascular dementia (VD), a prevalent neurodegenerative disorder that stems from chronic cerebral hypoperfusion, poses a substantial clinical challenge given the scarcity of efficacious treatment options. While ...
Exploring the neuroprotective effect and potential mechanism of Shenrong Guben Huanshao Pill based on multi-omics analysis [0.03%]
基于组学分析探究神容固本还少丸的神经保护效应及作用机制
Wenjun Cui,Yanping Wang,Yazhou Shao et al.
Wenjun Cui et al.
Background: Shenrong Guben Huanshao Pill (SRGBHSP) is a traditional Chinese medicine (TCM) compound preparation derived from ancient classical prescriptions, widely utilized in clinical treatment of chronic kidney injury,...
Pulmonary microvascular endothelial glycocalyx degradation as a key driver in COPD progression and its protection by Tongxinluo [0.03%]
通心络对肺微血管内皮糖萼破坏的保护作用及其抗慢性阻塞性肺疾病进展的作用机制研究
Jing Guo,Jiemeng Sun,Mingyu Xiong et al.
Jing Guo et al.
Background: Chronic Obstructive Pulmonary Disease (COPD) is a major cause of morbidity and mortality worldwide. Pulmonary microvascular endothelial glycocalyx (PMEG) has been found to be significantly reduced in COPD, but...
Voacamine initiates the PI3K/mTOR/Beclin1 pathway to induce autophagy and potentiate apoptosis in acute myeloid leukemia [0.03%]
vogel钩藤碱通过启动PI3K/m TOR/beclin1途径诱导自噬并促进急性髓系白血病细胞凋亡
Yuening Cao,Yan Wang,Ying Chen et al.
Yuening Cao et al.
Background: Acute myeloid leukemia (AML) is notoriously prevalent as a malignant hematological neoplasm, and commonly prescribed combination chemotherapeutic treatments invariably involve unanticipated toxicities. Therefo...
Cinnamic acid-GPR109A pathway improves skeletal muscle hypertrophy and metabolism [0.03%]
肉桂酸-GPR109A信号轴促进骨骼肌肥大和代谢适应
Zewei Ma,Penglin Li,Xiaohua Feng et al.
Zewei Ma et al.
Background: Cinnamic acid (CA), a phenylalanine metabolite found in various plants, such as Cinnamomi ramulus, a key role in regulating biological process, like proliferation, osteoblast differentiation, glucose and lipid...
Icaritin induces paraptosis in hepatocellular carcinoma cells by targeting BHLHE40 via endoplasmic reticulum stress and mitochondrial dysfunction [0.03%]
ICARITIN通过内质网应激和线粒体功能障碍靶向BHLHE40以诱导肝癌细胞发生类凋亡死亡
Wencheng Wei,Hao Wang,Li Fu et al.
Wencheng Wei et al.
Objective: Icaritin, a flavonoid derived from the traditional Chinese medicine Epimedium, exhibits diverse biological activities; however, the mechanisms underlying its effects against hepatocellular carcinoma (HCC) remai...
Lingguizhugan decoction ameliorates renal injury secondary to heart failure by improving pyroptosis through TLR4/NF-KB/IRE1α pathway [0.03%]
苓桂术甘汤通过TLR4/NF-κB/IRE1α信号通路改善心力衰竭继发性肾损伤的作用及机制研究
Jiayu Lv,Zhenyue Fu,Yuxin Wang et al.
Jiayu Lv et al.
Background: Chronic heart failure (CHF) and chronic kidney disease (CKD) mutually promote the onset and progression of each other. Renal injury caused by heart failure currently lacks effective treatments. Previous studie...
Celastrol attenuates ferroptosis-mediated intestinal ischemia/reperfusion-induced acute lung injury via Hippo-YAP signaling [0.03%]
雷公藤红素通过Hippo-YAP信号通路减弱肠道缺血/再灌注诱导的急性肺损伤介导的铁死亡
Xin Fan,Yinxin Ai,Guo Mu et al.
Xin Fan et al.
Background: Acute lung injury commonly arises as a secondary complication following intestinal ischemia/reperfusion (II/R) injury. Celastrol (CEL), recognized for its therapeutic effects on inflammation-related conditions...