The promoting effect of high-fat diet-induced trained immunity on ulcerative colitis and the mechanism of the therapeutic effect of Dahuang Mudan Decoction [0.03%]
高脂饮食训练免疫对溃疡性结肠炎的促病效应及大黄牡丹汤的治疗机制研究
Pengcheng Li,Rui Xu,Hongxu Chen et al.
Pengcheng Li et al.
Background: Ulcerative colitis (UC) is a chronic inflammatory disease driven by intestinal immune imbalance. In addition, its pathogenesis includes environment, genetics, microbiota, genes, and diet. Epidemiological and r...
Kirenol alleviates cerebral ischemic injury by promoting synaptic plasticity via HDAC2-mediated BDNF expression [0.03%]
苦木素通过HDAC2介导的BDNF表达促进突触可塑性以缓解脑缺血损伤
Min Guo,Yonghua Ye,Xuezhen Li et al.
Min Guo et al.
Background: Ischemic stroke is an acute cerebrovascular disorder posing various public health challenges; however, the treatment is lacking. Kirenol (Kir), a natural diterpenoid compound with various bioactive properties,...
Lutein: A natural defence combating age-related macular degeneration [0.03%]
叶黄素：一种对抗年龄相关性黄斑变性的天然防御物质
Madhubala Ganeshbabu,Janani Manochkumar,Thomas Efferth et al.
Madhubala Ganeshbabu et al.
Background: Recently, lutein has been gaining wide attention in the nutraceutical market due to its remarkable antioxidant and anti-inflammatory properties. Yet, about 200 million people across the globe are estimated to ...
Predicting the molecular mechanism of ginger targeting PRMT1/BTG2 axis to inhibit gastric cancer based on WGCNA and machine algorithms [0.03%]
基于WGCNA和机器算法预测姜活性成分靶向PRMT1/BTG2轴抑制胃癌的分子机制
Guoqing Chen,Boyun Gou,Yuhua Du et al.
Guoqing Chen et al.
Objective: The aim of this study was to screen the biomarkers of ginger against gastric cancer (GC) by network pharmacology, WGCNA and machine algorithms. To find the upstream transcription factors and downstream signalin...
Periplocin targets LRP4 to regulate metabolic homeostasis and anti-inflammation for the treatment of IVDD [0.03%]
皮洛昔定靶向LRP4调节代谢稳态和抗炎作用用于治疗IVDD
Zhenchuan Liu,Fei Qiao,Dejian Liu et al.
Zhenchuan Liu et al.
Background: Intervertebral disc degeneration (IVDD) is characterized by deteriorating intervertebral discs, leading primarily to low back pain and leg pain. Most current treatments for IVDD primarily address symptoms with...
Hyperoside alleviates zearalenone-induced liver injury by regulating mitochondrial calcium overload mediated excessive autophagy [0.03%]
_hyperoside通过调节线粒体钙超载介导的过度自噬缓解玉米赤霉烯酮诱导的肝损伤
Tianyu Han,Lulu Wang,Yan Jiang et al.
Tianyu Han et al.
Background: Zearalenone (ZEA), one of the most common mycotoxins in moldy plants, can cause ferroptosis in the liver. Hyperoside (Hyp) is mainly derived from Hypericum perforatum and exerts hepatoprotective, neuroprotecti...
Angoroside C: A potent AMPK activator in the aqueous extract of Scrophularia ningpoensis, alleviates metabolic syndrome in db/db mice [0.03%]
宁波玄参水提物抗代谢综合征活性成分安格苏糖苷C的鉴定及其机制研究
Xiaohan Li,Yue Zhang,Chunxiao Yu et al.
Xiaohan Li et al.
Background: Scrophularia ningpoensis Hemsl. (SN) is a traditional herbal medicine used for treating diabetes mellitus (DM). Previous studies indicated that the aqueous extract of SN (AESN) improves type 2 DM (T2DM) by act...
Xuanfei Baidu Formula confers protection against viral pneumonia by modulating CD8+ T cell proliferation via MAPK signalling pathway [0.03%]
玄符百度方通过MAPK信号通路调节CD8⁺T细胞增殖防治病毒性肺炎
Tao Liu,Mingyu Ding,Ruihan Chen et al.
Tao Liu et al.
Background: Viral pneumonia is a common clinical infectious disease in which host immunity plays a pivotal role in its onset and progression. A compromised adaptive immune response, particularly involving CD8+ T cells, is...
Transcriptomic strategy provides molecular insights into the growth and ginsenosides accumulation of Panax ginseng [0.03%]
转录组策略揭示了人参生长和皂苷积累的分子见解
Zhonggen Zhan,Jue Zhang,Weisu Huang et al.
Zhonggen Zhan et al.
Background: Panax ginseng C. A. Meyer, a well-known phytomedicine has been widely used in traditional medicine for centuries. However, its quality and yield are heavily influenced by environmental conditions and cultivati...
Resveratrol attenuates prenatal X-ray-induced microcephaly and adult depression via SIRT1-mediated senescence suppression and TPH2/5-HT pathway restoration in mice [0.03%]
白藜芦醇通过SIRT1介导的衰老抑制和TPH2/5-HT通路恢复缓解小鼠宫内放射性照射诱导的小头畸形和成年期抑郁反应
Yu Feng Zhang,Ze Lin Xu,Chen Wang et al.
Yu Feng Zhang et al.
Background: With increasing use of medical imaging (e.g., CT scans) and environmental radiation sources, over 2 % of pregnancies worldwide are inadvertently exposed to low-dose ionizing radiation (IR), raising urgent conc...