18β-Glycyrrhetinic acid from Glycyrrhiza Uralensis protects colonic epithelium in ulcerative colitis by activating Wnt/β-catenin pathway to restore tight junction [0.03%]
甘草酸通过激活Wnt/β-catenin信号通路修复紧密连接来保护溃疡性结肠炎的结肠上皮细胞
Xi Peng,Rao Zhong,Shi Dong et al.
Xi Peng et al.
Background: Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by persistent inflammation of the colon. Glycyrrhiza uralensis extract (ULE), a traditional medicinal plant extract, is globally re...
Disruption of cholesterol homeostasis triggers NLRP3-cGAS-STING axis-dependent hepatic fibrosis and honokiol intervention effects [0.03%]
胆固醇稳态紊乱通过NLRP3-cGAS-STING轴依赖机制触发肝纤维化及虎皮楠素干预作用
Zhilei Wang,Jingwen Liu,Yu Mou et al.
Zhilei Wang et al.
Background: Maintaining cholesterol homeostasis is crucial for sustaining human health and physiological function. Although the detrimental effects of chronic cholesterol overload on hepatic injury and fibrosis are well d...
UPLC-Q-TOF-MS based investigation into the bioactive compounds and molecular mechanisms of Qishen Huanwu capsule attenuates anthracycline-induced cardiotoxicity [0.03%]
基于UPLC-Q-TOF-MS的通心络胶囊防治蒽环类药物心脏毒性的活性成分及机制研究
Jin-Meng Lv,Li-Xin Wang,Jing Yang et al.
Jin-Meng Lv et al.
Background: Cardiotoxicity is a prevalent side effect linked to anthracyclines, a class of chemotherapy drugs, that frequently leads to the discontinuation of anthracycline-based treatments among cancer patients. Thus, th...
Multi-omics analysis reveals Angelica sinensis-Carthamus tinctorius herb pair ameliorates diabetic retinopathy comorbid with depressive symptoms via the gut-eye-brain axis [0.03%]
多组学分析揭示当归川芎药对通过肠-眼-脑轴改善糖尿病视网膜病变并抑郁症状
Rui Shen,Wenjuan Zhao,Yuting Wang et al.
Rui Shen et al.
Background: Diabetic retinopathy (DR) comorbid with depressive symptoms represents a significant public health challenge. The limitations of monotherapeutic approaches and the complex interplay between DR and depression h...
ZuoJin Pill intervention in HCT116 tumor-bearing mice: Modulation of tumor growth, intestinal barrier integrity and microbial composition [0.03%]
左金丸对移植HCT116肿瘤小鼠瘤体生长、肠屏障结构及肠道菌群的影响
Jingwen Chen,Yu Wang,Xiaoxian Liu et al.
Jingwen Chen et al.
Background: The progression of colorectal cancer (CRC) disrupts the intestinal mucosal barrier, and impacting patient prognosis. Traditional chemotherapy often induces gastrointestinal toxicity by damaging this barrier. Z...
Reporting quality and evidence support in randomized controlled trials of herbal medicine formulas for vestibular migraine [0.03%]
随机对照试验中报道质量及证据支持度对内耳眩晕病的中药方剂的影响
Lixiang Wang,Jueyan Zheng,Jiangli Yang et al.
Lixiang Wang et al.
Background: Vestibular migraine (VM) is a prevalent condition characterized by recurrent episodes of dizziness, vertigo, and/or headache, often posing diagnostic and therapeutic challenges. Numerous randomized controlled ...
The exploration of the effect and mechanism of Shengxian decoction inhibiting acute high-altitude myocardial injury [0.03%]
生仙汤防治急性高原心肌损伤的效果及机制探讨
Zhihan Chen,Lingyuan Zhong,Mengsong Liu et al.
Zhihan Chen et al.
Background: The heart is the most vulnerable organ to acute hypobaric hypoxia exposure, acute high-altitude myocardial injury (AHMI) typically occurs in individuals who rapidly ascend from lowland areas to high-altitude r...
Poliumoside alleviates microglia-mediated inflammation and blood-brain barrier disruption via modulating the polarization of microglia after ischemic stroke in mice [0.03%]
多糖藻素通过调节小鼠缺血性脑卒中后的小胶质细胞极化减轻小胶质细胞介导的炎症和血脑屏障破坏
Yuxiao Gao,Jingjing Wang,Cong Zhang et al.
Yuxiao Gao et al.
Background: Ischemic stroke remains a life-threatening condition with limited therapeutic options. Microglia-mediated neuroinflammation critically exacerbates acute ischemic injury. The active compound poliumoside (Pol) i...
Hydroxysafflower yellow A mitigates renal ischemia-reperfusion injury by inhibiting the CCR4-mediated apoptosis pathway [0.03%]
羟基红花黄色素A通过抑制CCR4介导的凋亡信号减轻肾缺血再灌注损伤
Rui-Yu Wang,Dan Jia,Wen-Qiang Zhang et al.
Rui-Yu Wang et al.
Background: Renal ischemia-reperfusion injury (RIRI) is a major contributor to acute kidney injury (AKI), associated with high mortality in intensive care units. Hydroxysafflower yellow A (HSYA), with known anti-inflammat...
Erchen Decoction ameliorates the rat model of polycystic ovary syndrome by regulating the steroid biosynthesis pathway [0.03%]
二陈汤通过调节类固醇生物合成途径改善多囊卵巢综合征模型大鼠病情
Jinrong Zhang,Hongming Huang,Min Xiao et al.
Jinrong Zhang et al.
Background: Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder associated with chronic inflammation and metabolic issues, including insulin resistance, weight gain, and lipid imbalance. It may c...