Thymoquinone alleviates myocardial ischemia/reperfusion injury by stabilizing mitochondria-associated membrane homeostasis via targeting ATAD3A [0.03%]
姜黄素活性成分(thymoquinone)通过靶向ATAD3A稳定线粒体相关膜来缓解心肌缺血再灌注损伤
Zeyu Li,Suiqing Huang,Li Luo et al.
Zeyu Li et al.
Background: Recent research has shown that regulating the homeostasis of mitochondria-associated endoplasmic reticulum membrane (MAM) to improve ER-mitochondrial communication holds promise for treating myocardial ischemi...
Ponicidin triggered ferroptosis in esophageal squamous cell carcinoma by suppressing the SLC7A11/Glutathione/GPX4 signalling axis [0.03%]
ponicidin通过抑制SLC7A11/谷胱甘肽/GPX4信号轴触发食管鳞状细胞癌铁死亡
Wenhu Liu,Jinhua Zhang,Min Wu et al.
Wenhu Liu et al.
Background: Ponicidin, a diterpenoid derived from Rabdosia rubescens, exhibits potent antitumor activity. However, its mechanisms against esophageal squamous cell carcinoma (ESCC) remain obscure. This study aims to explor...
Salvianolic acid A acts as a herpes simplex virus dual inhibitor by blocking glycoprotein B-mediated adsorption and membrane fusion [0.03%]
salvianolic酸A通过阻止糖蛋白B介导的吸附和膜融合双重抑制单纯疱疹病毒
Han Yan,Haihua Li,Xiayu Chen et al.
Han Yan et al.
Background: The development of novel anti-herpes simplex virus (HSV) agents with high efficacy and low toxicity is great importance. Salvianolic acid A (SAA), a stilbenoid caffeic acid trimer from Salvia miltiorrhiza Bung...
Jianpi Huayu decoction enhances the antitumor effect of doxorubicin via piezo1-mediated autophagy in hepatocellular carcinoma [0.03%]
健脾化瘀汤通过Piezo1介导的自噬增强肝癌中多柔比星的抗肿瘤作用
Chongkai Fang,Silin Liu,Sijia Zhang et al.
Chongkai Fang et al.
Background: Hepatocellular carcinoma (HCC) carries a poor prognosis, especially in advanced stages. Although Piezo1, a mechanosensitive ion channel, is linked to HCC progression, its underlying mechanisms and therapeutic ...
Network pharmacology and experimental validation of inflammation inhibition by ChuanKeZhi Injection in treating asthma [0.03%]
基于川 kezhi 注射液抗哮喘镇咳作用网络药理学及实验验证研究
Jiaying Yuan,Yuhan Wang,Bingxian Sha et al.
Jiaying Yuan et al.
Background: Chuankezhi injection (CKZ), derived from the traditional Chinese herbs Ying-Yang-Huo (Epimedium brevicornu Maxim) and Ba-Ji-Tian (Morinda officinalis F.C. How), has demonstrated remarkable clinical effects in ...
Metabolomics and integrated network pharmacology analysis revealed multi-targeted anti-cancer effect of FuZhengXiaoJi decoction against non-small cell lung cancer [0.03%]
基于代谢组学和网络药理学的扶正消积方抗非小细胞肺癌多靶点作用机制研究
Xinyuan Jiang,Zhiyong Xu,Huan Wang et al.
Xinyuan Jiang et al.
Background and purpose: As a malignant tumor characterized by a dismal prognosis and a high mortality rate, non-small cell lung cancer (NSCLC) presents significant challenges in contemporary treatment. These challenges in...
Protective effect of a novel nonsteroidal organoselenium compound SLL-1-43 on ulcerative colitis through down-regulating NOX2 signaling pathway in vitro and in vivo [0.03%]
一种新型非甾体有机硒化合物SLL-1-43通过体内和体外调节NOX2信号通路保护溃疡性结肠炎的作用机制研究
Lili Chen,Wenqian Pang,Xiaoqin Luo et al.
Lili Chen et al.
Background: Inflammatory bowel disease (IBD), including ulcerative colitis (UC), is a global health concern characterized by chronic inflammation and oxidative stress. These factors play pivotal roles in its pathogenesis,...
Mechanism of puerarin alleviating myocardial remodeling through NSUN2-mediated m5C methylation modification [0.03%]
通过NSUN2介导的m5C甲基化修饰机制研究葛根素抗心室重构的作用及分子机理
Yahua Wu,Xiaomin Huang,Yun He et al.
Yahua Wu et al.
Background: Myocardial remodeling is a primary contributor to the development and progression of heart failure. Reversing this process is crucial for the prevention and treatment of heart failure. Puerarin (Pue), a tradit...
Mechanism of Dihydroartemisinin in activating macrophages to enhance host resistance to malaria [0.03%]
双氢青蒿素激活单核细胞增强机体抗疟潜能的机制研究
Xin Li,Qilong Li,Ning Jiang et al.
Xin Li et al.
Background: The property of dihydroartemisinin (DHA) in promoting host immunohomeostasis, apart from its potent antimalarial activity, has been well-recognized. However, the mechanism of DHA in activating macrophages to e...
Schisandrol B alleviated diabetic cardiac injury by inhibiting ferroptosis and improving lipid metabolism in mice [0.03%]
schisandrol B通过抑制铁死亡和改善脂质代谢缓解小鼠糖尿病心脏损伤
Zi-Chang Niu,Qi Jin,Qian-You Shen et al.
Zi-Chang Niu et al.
Background: Diabetic cardiomyopathy (DCM) is a major complication of diabetes mellitus, highlighting the need to elucidate its pathogenesis and explore potential therapeutic interventions. ...