Insights into the functional characteristics of rhubarb (Rheum officinale Baill) treatment on experimental traumatic brain injury through network pharmacology with metagenomics [0.03%]
网络药理学和元基因组学指导下的人参对实验性脑外伤功能特点的洞察研究
Fei Zheng,Xiaohang Guo,Wei Zhang et al.
Fei Zheng et al.
Background: Traumatic brain injury (TBI) imposes a heavy burden on society and families owing to its high morbidity and mortality. Rhubarb has been noticed in the Chinese herb for treating TBI. The pharmacological effects...
Kangquan formula ameliorates the benign prostatic hyperplasia induced by testosterone propionate in rats by regulating urine microecology and metabolic profile [0.03%]
补肾平肝制剂通过调节尿液微生态和代谢谱改善雄激素致大鼠良性前列腺增生的作用研究
Cheng-Chen Li,Dian Zeng,Hui-Ling Tang et al.
Cheng-Chen Li et al.
Background: Kangquan formula (KQF), a traditional Chinese medicine compound, is clinically effective and safe against benign prostatic hyperplasia (BPH). However, the mechanism of action of KQF is not clear. ...
Exploring the neuroplasticity hypothesis in depression: The role of traditional Chinese herbal medicine [0.03%]
抑郁症中的神经可塑性假说探究——传统中药的作用
Jiuseng Zeng,Ziyu Wang,Xiongwei Zhang et al.
Jiuseng Zeng et al.
Background: Depression is a mental disorder that seriously affects global health, and its pathogenesis involves multiple factors, including changes in neuroplasticity. The neuroplasticity hypothesis suggests that there ma...
Unveiling XinJia-LuHuang Granules' protective mechanism against atherosclerosis: Integrating network pharmacology, metabolomics, and experimental validation [0.03%]
新癀片防治动脉粥样硬化的保护机制研究：网络药理学、代谢组学与实验验证相结合的方法学探索
Xueqian Liu,Lele Liu,Xiang Ren et al.
Xueqian Liu et al.
Background: Atherosclerosis (AS) is a primary contributor to cardiovascular disease. XinJia-LuHuang Granules (XLG), a formula used in traditional Chinese medicine (TCM), has been employed to treat AS. However, the underly...
Chemoproteomics reveals Ailanthone directly binds to PKM2 to inhibit the progression of Hepatocellular carcinoma [0.03%]
化学蛋白质组学揭示了独竧行星直接与PKM2结合可抑制肝细胞癌的发展
Cheng Lin,Yue Wan,Qiang Huo et al.
Cheng Lin et al.
Background: Hepatocellular Carcinoma (HCC) is a widely recognized aggressive tumor, owing primarily to its high recurrence and metastasis risk. On the other hand, Ailanthone (AIL), a natural plant derivative, has demonstr...
Chlorogenic acid and ferulic acid in SMYAD alleviate diabetic cardiomyopathy by inhibiting cardiac lipotoxicity via GCGR/PPARα and GCGR/AMPK pathways [0.03%]
SMYAD 中的绿原酸和香草酸通过GCGR/PPARα 和 GCGR/AMPK 通路抑制心脏脂毒性从而缓解糖尿病心肌病
Lin Li,Kai Huang,Dong Wang et al.
Lin Li et al.
Background: Diabetic cardiomyopathy (DCM) causes a high risk of heart failure, necessitating effective therapies. The Si-Miao-Yong-An decoction (SMYAD) has been widely applied in the clinical management of diabetes mellit...
Hickory nut polyphenols enhance oxidative stress resilience and improve the longevity of Caenorhabditis elegans through modulating DAF-16/DAF-2 insulin/IGF-1 signaling [0.03%]
霍克斯坚果多酚通过调节daf-16/daf-2胰岛素/igf-1信号通路增强氧化压力耐受性并改善秀丽隐杆线虫寿命
Song Wang,Chenyu Jiang,Shitong Yu et al.
Song Wang et al.
Background: Hickory (Carya cathayensis) nuts, renowned for their health benefits and delightful taste, contain abundant bioactive compounds, particularly polyphenols. However, the specific mechanisms underlying their anti...
CBX5 loss drives Pl3Kδ inhibitor resistance in mantle cell lymphoma and propolis restores sensitivity by inducing CBX5-mediated ferroptosis [0.03%]
CBX5丢失驱动Pl3Kδ抑制剂在套细胞淋巴瘤中的耐药性，而蜂胶可通过诱导CBX5介导的铁死亡恢复敏感性
Jun Lu,Ya-Qin Yang,Jia-Yi Tang et al.
Jun Lu et al.
Background: The generation of drug-resistance limits chemotherapy application such as phosphoinositide 3-kinase δ (PI3Kδ) inhibitors in mantle cell lymphoma (MCL). Propolis has been regarded as a resistance reversal age...
Paeonol ameliorates diabetic nephropathy by promoting TFEB-mediated lysosome biogenesis and lipophagy [0.03%]
芍药醇通过促进TFEB介导的溶酶体生物发生和脂质自噬来改善糖尿病肾病
Sinan Ai,Jiayin Tao,Yaoxian Wang et al.
Sinan Ai et al.
Rationale: Diabetic nephropathy (DN) is a significant clinical and public health burden worldwide whose magnitude underscores the urgent need for more effective treatment options. Excessive lipid accumulation in renal tub...
Daidzein alleviates ethanol-induced acute gastric injury in rats by targeting ESR1 and activating the PI3K/AKT/CREB signaling pathway [0.03%]
染料木素通过靶向ESR1和激活PI3K/AKT/CREB信号通路缓解乙醇诱导的大鼠急性胃损伤
Tao Jiang,Shengyi Du,Zexin Wang et al.
Tao Jiang et al.
Background: Alcohol-induced gastric ulcers (GU) rank among the most prevalent upper gastrointestinal diseases, severely impacting patients' quality of life and health. Daidzein (DAI), one of the primary active compounds p...