Hydroxysafflor yellow A ameliorates myocardial ischemia/reperfusion injury by promoting MDH1-mediated mitochondrial metabolic homeostasis [0.03%]
羟基红花黄色素A通过促进MDH1介导的线粒体代谢稳态改善心肌缺血再灌注损伤
Feng Zhao,Wen Cheng,Dan Wu et al.
Feng Zhao et al.
Background: Myocardial ischemia/reperfusion injury (MIRI) is a critical complication in the management of acute myocardial infarction, substantially compromising clinical outcomes. Hydroxysafflor yellow A (HSYA), a natura...
Curdione inhibits the proliferation of human uterine leiomyomas by targeting YTHDF1 [0.03%]
Curdione通过靶向YTHDF1抑制人类子宫肌瘤的增殖
Xuan Yang,Jiheng Zuo,Tiantian Qiu et al.
Xuan Yang et al.
Background: Curdione, an active sesquiterpene found in Curcumae Rhizoma, exhibits strong anti-inflammatory and antitumor properties, but its mechanism of action against uterine leiomyomas (ULMs) is not yet clear. ...
Gene signature-guided isolation identifies cucurbitacins as STAT3 inhibitors from Picria fel-terrae Lour [0.03%]
基因谱系引导分离发现Picria fel-terrae Lour中STAT3抑制剂琥珀酸盐类化合物
Shengrong Li,Qianyu Wang,Lei Xiang et al.
Shengrong Li et al.
Background: The transcription activator factor signal transducer and activator of transcription 3 (STAT3) diseases, such as triple-negative breast cancer (TNBC), making the need to identify new inhibitors crucial for effe...
Deciphering the therapeutic potential of Sinigrin: A promising anti-inflammatory agent for chronic disease management [0.03%]
解读黑芥子硫苷的治疗潜力：一种有前景的抗炎剂，用于慢性病管理
Dongzhou Du,Wenying Lan,Huan Wang et al.
Dongzhou Du et al.
Background: Sinigrin, an aliphatic glucosinolate abundantly present in cruciferous vegetables, has garnered attention for its significant anti-inflammatory, antioxidant, antibacterial, and anticancer properties, positioni...
Mechanism of Huoshan large-leaf yellow tea in treatment of diabetic cognitive dysfunction based on bioinformatics and network pharmacology [0.03%]
基于生物信息学和网络药理学的霍山大叶黄芽茶改善糖尿病认知功能障碍的作用机制研究
Rui Li,Qi Lou,Yu Zhu et al.
Rui Li et al.
Background: Diabetic cognitive dysfunction (DCD) is a prevalent complication of diabetes, characterized by progressive cognitive decline. Current pharmacological interventions have limited therapeutic efficacy in managing...
Phenotypic screening identified polydatin alleviating cartilage degeneration by modulating SIRT3-dependent mitochondrial dysfunction [0.03%]
表型筛选鉴定出茋通过调节SIRT3依赖的线粒体功能障碍缓解软骨退化
Aomeng Mao,Yajing Fu,Menghan Zhang et al.
Aomeng Mao et al.
Background: Osteoarthritis (OA) is a prevalent degenerative disease, characterized by articular cartilage lesions, synovial inflammation, and osteophyte formation, which ultimately results in joint deformity and limited m...
YiQiChuTan formula (YQCTF) inhibit the progression of non-small cell lung cancer via down-regulating EGFR/ITGB2 signaling: Triangulated evidence from network pharmacology, proteomic profiling, and experimental validation [0.03%]
益气除痰方通过下调EGFR/ITGB2信号通路抑制非小细胞肺癌的进展：网络药理学、蛋白质组学和实验验证的三角证据
Zhi-Hao Wu,Ming-Jun Li,Yu-Lin Hong et al.
Zhi-Hao Wu et al.
Background: YiQiChuTan Formula (YQCTF) is a traditional Chinese medicine formula composed of eight carefully selected herbal materials. which therapeutic efficacy has been clinically verified as it inhibits the progressio...
Effects of Chinese herbal medicine on the secondary prevention of chemotherapy-induced thrombocytopenia in malignant solid tumors, a randomized clinical trial [0.03%]
中药预防恶性实体瘤化疗所致血小板减少的二次研究——随机对照试验
Yanan Yang,Weilin Ge,Wei Luo et al.
Yanan Yang et al.
Objective: Thrombocytopenia is the main limiting toxicity of chemotherapy, which has not been adequately addressed until now. However, no exact studies have been conducted on the secondary prevention of chemotherapy-induc...
Corrigendum to "Protective effect of alizarin on vascular endothelial dysfunction via inhibiting the type 2 diabetes-induced synthesis of THBS1 and activating the AMPK signaling pathway" [Phytomedicine 128 (2024) 155557] [0.03%]
对“阿丽娜通过抑制2型糖尿病诱导的THBS1合成和激活AMPK信号通路对血管内皮功能障碍的保护作用”[Phytomedicine 128 (2024) 155557]的勘误通知书
Mo-Li Zhu,Jia-Xin Fan,Ya-Qi Guo et al.
Mo-Li Zhu et al.
Corrigendum to " Alizarin attenuates oxidative stress-induced mitochondrial damage in vascular dementia rats by promoting TRPM2 ubiquitination and proteasomal degradation via Smurf2" [Phytomedicine Phytomedicine 135 (2024) 156119] [0.03%]
对“阿勒山素通过促进TRPM2泛素化和蛋白酶体降解减轻氧化应激引起的血管性痴呆大鼠线粒体损伤[Phytomedicine 135 (2024) 156119]”的勘误通知书
Guo-Pin Pan,Yan-Hua Liu,Ming-Xu Qi et al.
Guo-Pin Pan et al.