Integrated metabolomics and network pharmacology reveal the PI3K/Akt-mediated therapeutic mechanism of Abrus cantoniensis in lipid metabolism disorders [0.03%]
整合代谢组学和网络药理学揭示了 Cantoni 苦豆子通过PI3K/AKT介导的治疗机制改善脂质代谢紊乱
Xue Wang,Mingjuan Huang,Yixiang Lu et al.
Xue Wang et al.
Background: Abrus cantoniensis (AC), a hepatoprotective herb, shows therapeutic potential for lipid metabolism disorders (LMDs), yet its mechanisms remain unclear. ...
Corrigendum to "Geniposide via enema alleviates colitis by modulating intestinal flora and bile acid metabolites, inhibiting S100A8/S100A9/NF-κB, and promoting TGR5 inhibition of NLRP3 inflammasome" [Phytomedicine, 142 (2025), 156791] [0.03%]
“番石榴素灌肠通过调节肠道菌群和胆酸代谢、抑制S100A8/S100A9/NF-κB并促进TGR5抑制NLRP3炎性小体来缓解结肠炎”一文的勘误 [Phytomedicine, 142 (2025), 156791]
Bao-Xin Zheng,Yan Yi,Xing-Wen Wang et al.
Bao-Xin Zheng et al.
Pleiotropic role of TLR2-mediated signaling in the protection of psoralidin against sepsis-induced acute lung injury [0.03%]
TLR2介导的信号转导在黄檀茋抗脓毒症急性肺损伤中的多效性作用
Shuai Jiang,Xuezeng Xu,Chao Deng et al.
Shuai Jiang et al.
Background: Sepsis, a life-threatening systemic inflammatory syndrome arising from dysregulated host response to pathogenic invasion, often leads to progressive multi-organ dysfunction, wherein acute lung injury typically...
Ginsenoside Rg5 ameliorates lipopolysaccharide (LPS)-induced acute liver injury via interfering Autophagy/Nrf2/Ferroptosis signal axis [0.03%]
稀有人参皂苷Rg5通过干扰自噬/Nrf2/铁死亡信号轴改善脂多糖诱导的急性肝损伤
Guan-Yue Shan,Yun-Peng Shi,Yu-Xin Zhang et al.
Guan-Yue Shan et al.
Background: Ginseng is a widely known Chinese herb, exerts its pharmacological effects primarily through ginsenosides. Ginsenoside-Rg5 is isolated from ginseng, has been shown to protect the liver and activate Nrf2 expres...
Apigenin suppresses keratinocyte hyperproliferation and inflammation in psoriasis by inhibiting CDK2/E2F2 pathway [0.03%]
阿皮辛通过抑制CDK2/E2F2通路抑制银屑病中的角质细胞过度增殖和炎症反应
Abudureyimu Alimujiang,Yutong Kang,Wenjing Wei et al.
Abudureyimu Alimujiang et al.
Background: Psoriasis is a long-lasting inflammatory skin condition marked by unusual growth of keratinocytes and infiltration of immune cells in the dermis and epidermis. Dijincao (DJC), a key component of Qing Xue Wan (...
Single-cell transcriptomic atlas reveals the underlying mechanism of indole-3-acetic acid in protecting against acute cholestatic liver injury [0.03%]
单细胞转录组揭示IAA抗急性胆汁淤积性肝损伤的潜在机制
Chen Xue,Penghui Li,Mengjuan Xuan et al.
Chen Xue et al.
Cholestasis resulting from disorders of bile secretion and excretion is a serious manifestation of hepatopathy. Indole-3-acetic acid (3-IAA), a biologically active indole derivative from the tryptophan metabolic pathway, has recently attrac...
Targeting tumor metabolism: The dual attack of emodin on glycolysis and oxidative phosphorylation in esophageal squamous cell carcinoma [0.03%]
靶向肿瘤代谢：大黄酚联合抑制食管鳞癌细胞的糖酵解和氧化磷酸化作用
Xin Su,Wanyu Yang,Zhiqiang Yan et al.
Xin Su et al.
Background: Esophageal squamous cell carcinoma (ESCC) exhibits elevated death rate and varying resistance to multiple chemotherapeutic agents. Emodin, a key constituent of rhubarb, has demonstrated anticancer activities i...
Exploring the therapeutic mechanism of Miao nationality medicine Qijiao Shengbai capsule on leukopenia based on multi-omics, network pharmacology and experimental verification [0.03%]
基于组学、网络药理及实验验证的苗医益气生血胶囊治疗白细胞减少症作用机制探讨研究
Wei Hu,Chen Li,Chenguang Wang et al.
Wei Hu et al.
Introduction: Leukopenia is caused by numerous factors, and modern drug therapies have obvious side effects, Qijiao Shengbai Capsule (QJSB) is a compound prescription developed from Miao medicine, widely used in clinical ...
Efficacy and safety of Chinese medicine in treating risk window of AECOPD: A multicenter randomized controlled trial [0.03%]
中医药干预急性加重期慢性阻塞性肺疾病风险窗的有效性和安全性：多中心随机对照试验
Jiansheng Li,Hailong Zhang,Huanrong Ruan et al.
Jiansheng Li et al.
Background: Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) significantly accelerate disease progression and substantially increase mortality risk. The risk window of AECOPD (AECOPDRW) represents a t...
Synergistic effects of heterophyllin B with nintedanib against experimental pulmonary fibrosis in mice [0.03%]
异叶素B与Nintedanib对小鼠实验性肺纤维化的协同治疗作用
Ce Chen,Zeyu Han,Jiawen Luo et al.
Ce Chen et al.
Background: Pulmonary fibrosis (PF) is a chronic, lethal lung disease marked by permanent alterations to the lung tissue architecture. Although nintedanib (NDN) has been approved for clinical use, its therapeutic potentia...