Integrated analysis of metabolomics, network pharmacology, and intestinal microbiota reveals Tibetan herb E'se ameliorate disorders of glycolipid metabolism in db/db mice [0.03%]
代谢组学、网络药理学和肠道微生物组的综合分析揭示了藏药E'se可改善db/db小鼠糖脂代谢紊乱
Luyao Zheng,Li Liu,Shangxiao An et al.
Luyao Zheng et al.
Background: E'se (Malus toringoides (Rehd.) Hughes or Malus transitoria (Batal.) Schneid) is widely used as a drug for the treatment of diabetes mellitus in China, but the mechanism by which E 'se regulates disorders of g...
Ershiwuwei Shanhu pills alleviates cerebral ischemia injury in rats by regulating endoplasmic reticulum stress through GRP78/XBP1/CHOP pathway [0.03%]
二五味山 hoop丸通过调控GRP78/XBP1/CHOP途径改善大鼠脑缺血损伤的作用研究
Mengtian Han,Jiaqing Fu,Zhuoma Suonan et al.
Mengtian Han et al.
Background: Ershiwuwei Shanhu pills (ESWWSHW, Tibetan name is བྱུ་དམར་ཉེར་ལྔ།) is a traditional Tibetan medicinal formulation utilized for the management of cerebral ischemia, which mainly includes 25 medic...
Potential of phytochemicals for pharmacotherapy of glioblastoma multiforme: Progress, pitfalls, and promise [0.03%]
植物化学物质在胶质母细胞瘤药物治疗中的潜力：进展、困境与前景
Adam Bobak,Michael Steves,Emily McMahon et al.
Adam Bobak et al.
Background: Glioblastoma multiforme (GBM) is known to be the most aggressive adult brain tumor due to its high fatality rates. The ability of this tumor to induce neovascularization, migrate, and proliferate into brain ti...
Dendrobine attenuates lipopolysaccharide-induced acute lung injury by modulating FAM134B-mediated endoplasmic reticulum autophagy and mitochondrial function [0.03%]
石斛碱通过调节FAM134B介导的内质网自噬和线粒体功能缓解脂多糖诱导的大鼠急性肺损伤
Jia Zhou,Sanzhong Li,Zhiguo Hu et al.
Jia Zhou et al.
Background: Macrophage-mediated excessive inflammatory responses play a pivotal role in sepsis progression, particularly in the lungs. Endoplasmic reticulum stress (ERS) and mitochondrial dysfunction, also contribute to t...
Mulberry leaf improves type 2 diabetes in mice via gut microbiota-SCFAs-GPRs axis and AMPK signaling pathway [0.03%]
桑叶通过肠道菌群-SCFA-GPR轴和AMPK信号通路改善小鼠2型糖尿病
Ying Zhang,Han Jiang,Xiao-Han Peng et al.
Ying Zhang et al.
Background: Mulberry (Morus alba L.) leaf is a Chinese herb used clinically to treat type 2 diabetes mellitus (T2DM) and has been proven to improve T2DM by regulating gut microbiota dysbiosis. However, it is currently unc...
Motherwort synergized with oxytocin for postpartum hemorrhage prevention: Integrated clinical efficacy and mechanism exploration [0.03%]
钩旱莲协同缩宫素预防产后出血的临床及机制探讨
Chen Chen,Qingsong Liu,Yongmei Lu et al.
Chen Chen et al.
Background: Postpartum hemorrhage (PPH) remains a leading cause of maternal mortality, while Chinese Motherwort (Leonurus japonicus Houtt.), known as "JingChanLiangYao", has been used to prevent PPH in traditional Chinese...
Multi-omics characterization of prognostic signature and novel molecular subtypes associated with anoikis and in vitro validation of CDKN2A in thyroid carcinoma [0.03%]
甲状腺癌预后特征和分子亚型的多组学表征及其抗悬浮凋亡与体外验证CDKN2A的作用
Kaigang Xie,Xiaoming Hong,Xiaoting Ren et al.
Kaigang Xie et al.
Background: Anoikis plays a crucial role in thyroid carcinoma (THCA). Recent evidence has suggested CDKN2A as a key anoikis-related gene (ARG) associated with THCA. However, the multi-omics regulatory landscape of ARGs an...
Narirutin downregulates USP15 to inhibit the NLRP3 ubiquitination in HDM-induced allergic rhinitis [0.03%]
narirutin通过下调USP15抑制HDM诱导的过敏性鼻炎中NLRP3泛素化
Jianing Yang,Longzhu Dai,Jingmei Chai et al.
Jianing Yang et al.
Background: Although tremendous progress has been made, the challenge of preventing and treating allergic rhinitis remains on a global scale. In recent years, there has been an increasing interest in the use of natural me...
Guggulsterone suppresses osteosarcoma progression by inhibiting glycolysis through MAPK signaling pathway [0.03%]
姜黄素生物活性成分通过MAPK信号通路抑制糖酵解从而抑制骨肉瘤进展
Qijing Wang,Xuhui Yuan,Hongyan Li et al.
Qijing Wang et al.
Background: Osteosarcoma (OS) represents an aggressive primary cancer originating in bone. It is predominantly diagnosed in pediatric and young adult populations, constituting approximately 20 % of bone malignancies in th...
Biomarkers and potential mechanisms of Chinese medicine compound (Chuanhong Zhongfeng Capsule) in the treatment of acute cerebral infarction [0.03%]
复方川红中医风药胶囊治疗急性脑梗死的生物标志物及其机制研究
Yingyue Ding,Jinwen Yao,Xu Wang et al.
Yingyue Ding et al.
Objective: Acute Cerebral Infarction (ACI) is characterized by high disability and recurrence rates, posing a significant threat to public health. The Chuanhong Zhongfeng (CHZF) Capsule, developed by national medical mast...