Shen-Ying-Yang-Zhen formula promotes angiogenesis around hair follicles, alleviates oxidative stress, and inhibits hair follicle apoptosis through the VEGF/Akt/Caspase-9 signaling axis [0.03%]
参芪养真方通过血管内皮生长因子/蛋白激酶B/半胱氨酸天冬氨酸蛋白酶9信号轴促进毛囊周围新生血管的形成、缓解氧化应激及抑制毛囊凋亡
Huixing Zhang,Lin Su,Yan Qiang et al.
Huixing Zhang et al.
Background: Androgenic alopecia (AGA) represents the most predominant form of hair loss in clinical practice, yet currently approved pharmacological options (e.g., finasteride and minoxidil) face limitations in safety and...
Emodin-induced ERα degradation via SYVN1 alleviates vascular calcification by preventing HIF-1α deacetylation in chronic kidney disease [0.03%]
Yongyan Chen,Xu Han,Yuxuan Hao et al.
Yongyan Chen et al.
Background: Vascular calcification is a major cause of death in chronic kidney disease (CKD), with osteoblastic transdifferentiation of vascular smooth muscle cells (VSMCs) considered to be the crucial pathologic process....
Natural products in rheumatoid arthritis: Cell type-specific mechanisms and therapeutic implications [0.03%]
Yang Liao,Xian Xiao,Wen Cheng et al.
Yang Liao et al.
Background: The pathogenesis of rheumatoid arthritis (RA) involves abnormal activation and interactions among various cell types. Traditional Chinese medicine (TCM) natural products show therapeutic potential with multi-t...
Moslae Herba extract alleviates hyperuricemia by regulating uric acid metabolism and relieving renal inflammation and fibrosis in mice [0.03%]
墨蓼 herb提取物通过调节尿酸代谢和缓解小鼠肾脏炎症及纤维化来降低高尿酸血症
Jian Guo,Huanhuan Liu,Tong Jin et al.
Jian Guo et al.
Background: Hyperuricemia (HUA) is a metabolic disease caused by uric acid metabolism disorder and is prevalent worldwide. Moslae Herba is a traditional herbal medicine known for its anti-inflammatory, antioxidant, and di...
Quinacrine induces autophagy via the Dlg5/AKT pathway to inhibit osteosarcoma cell proliferation and suppresses migration and invasion through the Dlg5/Girdin pathway [0.03%]
奎尼丁通过Dlg5 / AKT途径诱导自噬以抑制成骨细胞增殖并通过Dlg5 / Girdin途径抑制迁移和侵袭
Hongyu Li,Wenkai Chen,Xiangchen Zeng et al.
Hongyu Li et al.
Background: Osteosarcoma (OS) is a malignant tumor of bone that originates from mesenchymal cells. Although improvements have been made in the survival rate of five years, the outlook for individuals with metastatic or re...
Integrative fMRI and multiomics reveal neuroprotective mechanisms of Astragalus membranaceus in sleep deprivation-induced depression [0.03%]
基于睡眠剥夺诱导的抑郁模型系统解析膜荚黄芪神经保护机制
Yu Jiao,Dan Xiao,Xin Li et al.
Yu Jiao et al.
Background: Sleep deprivation (SD) is a significant public health concern and a risk factor for neuropsychiatric disorders, including depression. SD disrupts the gut-brain axis, causing dysbiosis and neuroinflammation. As...
Ciliatoside A attenuates neuroinflammation in Alzheimer's disease by activating mitophagy and inhibiting NLRP3 inflammasome activation [0.03%]
粘孢子虫苷A通过激活线粒体自噬和抑制NLRP3炎性小体活化来缓解阿尔茨海默病的神经炎症作用
Minsong Guo,Zhengqin Wang,Xiaogang Zhou et al.
Minsong Guo et al.
Background: Alzheimer's disease (AD) is a gradually worsening neurological condition that involves memory loss, brain inflammation, and impaired mitochondrial function. The NLRP3 inflammasome activation in microglia plays...
Suppressing ferroptosis via modulating FTH1 by silybin for treatment of renal fibrosis [0.03%]
通过调节FTH1抑制铁死亡以治疗肾纤维化：硅草素的作用
Jia-Qin Hu,Cang-Qiong Ning,Fang-Cao Pi et al.
Jia-Qin Hu et al.
Background: Renal fibrosis, a hallmark pathological manifestation of chronic kidney disease, arises from diverse etiological factors. While ferroptosis has emerged as a pivotal contributor to renal fibrogenesis, the regul...
Bufalin enhanced temozolomide efficacy by promoting EGFR protein degradation in glioblastoma [0.03%]
Bufalin通过促进EGFR蛋白降解增强胶质母细胞瘤中Temozolomide的疗效
Runze Yu,Yuhan Li,Bo Wang et al.
Runze Yu et al.
Background: Glioblastoma (GBM), the most aggressive form of glioma, is associated with a poor patient prognosis. Temozolomide (TMZ), the first-line chemotherapeutic agent for GBM patients, has its efficacy closely tied to...
Ranunculus ternatus Thunb. alkaloids attenuate colorectal cancer metastasis through EMT suppression [0.03%]
Ranunculus ternatus Thunb. 碱毒通过抑制上皮间质转化来减弱结直肠癌的转移
Yuchan Li,Liang Ye,Shixin Li et al.
Yuchan Li et al.
Background: Distant metastasis remains a major contributor to treatment failure and poor prognosis in colorectal cancer (CRC), emphasizing the urgent need for novel anti-metastatic strategies. Ranunculus ternatus Thunb. (...