Arbutin ameliorated depression by inhibiting neuroinflammation and modulating intestinal flora [0.03%]
阿魏酸通过抑制神经炎症和调节肠道菌群改善抑郁症状
Yu Cao,Kexuan Zhao,Yudi Zhao et al.
Yu Cao et al.
Background: Arbutin (AR), a natural glycoside compound widely distributed in botanical sources, exerts neuroprotective properties. Nevertheless, the pharmacological effect of AR on depression and its underlying mechanism ...
Rhizoma Panacis Majoris ameliorates rheumatoid arthritis by restoring apoptosis and autophagy dysregulation through reducing HMGB1 expression [0.03%]
radix panacis majoris通过减少hmgb1表达来改善类风湿性关节炎的细胞凋亡和自噬失调的作用研究
Xiayun Pang,Ruotong Song,Zheng Li et al.
Xiayun Pang et al.
Background: Restoring the autophagy and apoptosis balance in RA synovium may offer a promising RA treatment. Our previous research showed that total saponins from Rhizoma Panacis Majoris (RPMTG) exhibit anti-RA effects by...
Raspberry ketone alleviates radiation-induced lung injury through the STAT2-P2X7r/NLRP3 signaling pathway [0.03%]
raspberry酮通过STAT2-P2X7r/NLRP3信号途径缓解放射性肺损伤
Yu-Chen Jiang,Bin Zhao,Peng Jiang et al.
Yu-Chen Jiang et al.
Background: Radiation-induced lung injury (RILI) is a frequent side effect in patients with breast cancer receiving radiotherapy. Currently, there is no optimal radioprotective agent that is widely utilized for RILI treat...
Jiegeng Gancao Decoction Ameliorates Ulcerative Colitis: An Integrative Approach Combining Network Pharmacology and Proteomics via in silico and in vivo studies [0.03%]
桔梗甘草汤治疗溃疡性结肠炎：网络药理学和蛋白质组学相结合的整合研究（体外及体内研究）
Ruipeng Shi,Sio I Chan,Haochun Jin et al.
Ruipeng Shi et al.
Background: Ulcerative colitis (UC) is a chronic inflammatory condition of the colon that significantly affects the quality of life of patients. Although current treatments offer some relief, they are often accompanied by...
Integration of heart-on-a-chip and metabolomics for understanding the toxicity-attenuating effect of ethnomedicinal processing [0.03%]
集成心脏芯片与代谢组学理解民族医药炮制减毒效应
Xinmei Xu,Yue Liu,Shufu Yu et al.
Xinmei Xu et al.
Background: Tiebangchui (TBC), is a well-known traditional Tibetan medicine that coexists with toxicity and effects. Highland barley wine is an effective and unique processing method to reduce TBC's toxic side effects. Ho...
Eriodictyol from Scutellariae Barbata alleviates inflammation and necrosis via ZBP1-dependent signaling in acute pancreatitis [0.03%]
牻牛儿酮醇通过ZBP1依赖性信号减轻急性的胰腺炎的炎症和坏死作用
Simin Tian,Guang Xin,Kun Zhang et al.
Simin Tian et al.
Background: Acute pancreatitis (AP) is an inflammatory disease of the pancreas marked by inflammation and acinar cell necrosis. Scutellariae Barbata (S. Barbata), a traditional Chinese herb for inflammation, has unclear e...
Tanshinone IIA attenuates sepsis-induced lung injury by reducing VEGFR2/PI3K/AKT-driven mitochondrial disruption dependent apoptosis [0.03%]
丹参酮ⅡA通过减少VEGFR2/PI3K/AKT依赖的线粒体紊乱诱导性凋亡抑制脓毒症诱发的肺损伤
Delida Aidebaike,Hailong Gong,Yun Xia et al.
Delida Aidebaike et al.
Background: Sepsis-induced lung injury (SILI) is marked by excessive inflammation and apoptosis, posing considerable therapeutic problems owing to the scarcity of targeted therapy. Tanshinone IIA (TanIIA), a bioactive mol...
Protective effects of pollenin B in asthma: PPAR-γ-mediated regulation of inflammatory pathways and arachidonic acid metabolism [0.03%]
花粉素B对哮喘的保护作用：通过PPAR-γ介导的炎症通路和花生四烯酸代谢的调节作用
Yuanyuan Wu,Mengnan Zeng,Xinmian Jiao et al.
Yuanyuan Wu et al.
Background: Asthma poses a significant global health challenge, characterized by increasing prevalence and treatment complexities. Although Ephedrae Herba has long been used in asthma therapy, its pharmacological basis an...
Formononetin enhances cisplatin chemotherapy sensitivity in osteosarcoma by inducing ferroptosis and reconstructing the immune microenvironment [0.03%]
formikone素通过诱导铁死亡和重塑免疫微环境增强骨肉瘤的顺铂化疗敏感性
Yun Liu,Tianyu Xie,Jiming Liang et al.
Yun Liu et al.
Background: Osteosarcoma is a rare malignant tumor originating from bone tissue. Despite advancements in neoadjuvant chemotherapy, the 5-year survival rate for osteosarcoma patients has plateaued around 60 % for the past ...
Tanshinone IIA modulates Sirt5 and Metll3 interaction to govern mitochondria-endoplasmic reticulum unfolded protein response in coronary microvascular injury [0.03%]
丹参酮ⅡA通过调节Sirt5与Mettl3的互作调控冠状微血管损伤中的线粒体-内质网未折叠蛋白反应
Xiangyi Pu,Qiaomin Wu,Zhaoqi Yan et al.
Xiangyi Pu et al.
Background: Traditional Chinese medicine (TCM) has demonstrated significant advantages in the treatment of coronary microvascular injury, offering novel therapeutic strategies for cardiovascular diseases. Among its active...