Qing Hua Yu Du formula ameliorates alcoholic hepatic fibrosis by regulating MAPK/TLR4-MyD88 inflammatory pathways, restoring hepatic metabolism and modulating gut microbiota [0.03%]
清化郁毒方通过调节MAPK/TLR4-MyD88炎症通路、恢复肝脏代谢和调控肠道菌群改善酒精性肝纤维化
Jing Ding,Fangying Xu,Di Chen et al.
Jing Ding et al.
Background: Alcohol-induced liver injury (ALI) and subsequent hepatic fibrosis pose significant global health burdens, with limited effective therapeutic options. Traditional Chinese Medicine (TCM) formulas, such as Qing ...
Morus alba L. (Sangzhi) alkaloids alleviate diabetic nephropathy by suppressing endoplasmic reticulum stress and modulating AMPK-associated phosphatidylethanolamine content [0.03%]
桑枝生物碱通过抑制内质网应激及调控AMPK相关磷脂酰乙醇胺含量治疗糖尿病肾病
Shan Zhang,Zhige Wen,Xinyao Xu et al.
Shan Zhang et al.
Background: Diabetic nephropathy (DN) is frequently characterized by significant alterations in lipid metabolism, a pathological condition that amplifies renal injury and accelerates disease progression. Sangzhi alkaloid ...
Bushentongluo formula counteracts BMSCs senescence to alleviate postmenopausal osteoporosis by activating mitophagy via the SENP1-SIRT3 pathway [0.03%]
补肾通络方通过SENP1-SIRT3信号途径激活线粒体自噬对抗BMSCs衰老以缓解绝经后骨质疏松症
Shuai Chen,Lingling Yu,Ningsheng Tian et al.
Shuai Chen et al.
Background: Senescence and impaired osteogenic capacity of bone marrow mesenchymal stem cells (BMSCs) are pivotal pathogenic drivers in the progression of postmenopausal osteoporosis (PMOP). The Bushentongluo formula (BST...
The herbal compound miltirone from Salvia miltiorrhiza targets DJ-1 to induce mitophagic dysfunction and ROS-dependent hippo activation in gastric cancer [0.03%]
丹参化合物miltirone通过靶向胃癌中的DJ-1诱导线粒体自噬功能障碍和ROS依赖性Hippo激活
Chuhang Wang,Xiaochen Ni,Xiaojuan Liu et al.
Chuhang Wang et al.
Background: The protein DJ-1/PARK7 is highly expressed in various cancers and is involved in oxidative stress and mitophagy, making it a potential anti-cancer target. Salvia miltiorrhiza Bunge, a traditional Chinese herb,...
Ginsenoside Rh2 and luteolin synergistically induce cellular senescence to suppress hepatocellular carcinoma progression through oxidative stress-mediated mechanisms [0.03%]
人参皂苷Rh2和芹菜素通过氧化应激介导的机制协同诱导细胞衰老以抑制肝癌进展
Jieya Huang,Zhibing Wang,Ling Wu et al.
Jieya Huang et al.
Background: Hepatocellular carcinoma (HCC) remains one of the leading causes of cancer-related mortality worldwide, and effective therapeutic options are still limited. Inducing cellular senescence has emerged as a promis...
Si-Wu-Tang ameliorates chemotherapy-induced premature ovarian insufficiency by regulating a signaling pathway in endoplasmic reticulum stress [0.03%]
四物汤通过调节内质网应激信号通路改善化疗诱导的卵巢早衰
Yuli Geng,Yanjing Huang,Zhuo Liu et al.
Yuli Geng et al.
Background: Premature ovarian insufficiency (POI) is a clinically refractory reproductive system disorder. Our previous studies demonstrated that the traditional Chinese herbal formula Si-Wu-Tang (SWT) might ameliorate PO...
Multi-omics analysis and experimental verification reveal the role of dihydrocaffeic acid against 5-fluorouracil-induced intestinal mucositis [0.03%]
多组学分析及实验验证揭示咖啡酸二氢衍生物防治氟尿嘧啶诱导的肠粘膜炎的作用及机制
Junjie He,Hengxiang Shen,Ziwei Ye et al.
Junjie He et al.
Background: A common adverse effect of 5-fluorouracil (5-FU) in chemotherapy is intestinal mucositis (IM), which significantly impacts patients' quality of life. To date, no effective long-term treatment is available for ...
Seco-neokadsuranic acid A antagonizes SH3BP1 to suppress hepatocellular carcinoma progression through PPAR pathway activation [0.03%]
Seco-neokadsuranic酸A通过PPAR途径激活拮抗SH3BP1以抑制肝癌进展
Beixi Jia,Mengyang Liu,Xin Zhang et al.
Beixi Jia et al.
Background: The high mortality of hepatocellular carcinoma (HCC), driven by metastasis and drug resistance, underscores the need for novel therapeutics. The natural triterpenoid seco-neokadsuranic acid A (SA) shows promis...
Qishen Yiqi Dropping Pills ameliorate acute myocardial infarction by modulating PKM2/STAT3 pathway-mediated metabolic reprogramming in macrophages [0.03%]
杞参益气滴丸通过调节巨噬细胞PKM2/STAT3通路介导的代谢重编程改善急性心肌梗死
Aodi Fan,Yuting Huang,Qiuyu Lyu et al.
Aodi Fan et al.
Background and purpose: Acute myocardial infarction (AMI) is the leading cause of cardiovascular mortality worldwide. Timely reperfusion therapy is crucial to save the ischemic myocardium and prevent infarct expansion. In...
Paeonia × suffruticosa Andrews leaves improve endometriosis with anxiety/depression by regulating microglial polarization via JAK2/STAT3 pathway [0.03%]
丹皮酚通过调节JAK2/STAT3信号通路极化小胶质细胞治疗合并焦虑和抑郁的子宫内膜异位症
Yun-Yuan Tian,Lin-Yu Chen,Fei-Yu Xie et al.
Yun-Yuan Tian et al.
Background: Endometriosis (EMs) is a chronic inflammatory disease often treated with blood-activating and stasis-resolving therapies. Anxiety and depression are common mental comorbidities in patients with EMs. There are ...