Ferroptosis under fire: cannabidiol mitigates iron-dependent injury in differentiated human neuroblastoma cells following oxygen-glucose deprivation [0.03%]
铁死亡研究新进展：大麻二酚通过减轻缺氧和葡萄糖剥夺诱导的人神经母细胞瘤分化细胞的铁依赖性损伤发挥保护作用
Maciej Klimiuk,Małgorzata Jefimow,Hanna Kletkiewicz
Maciej Klimiuk
Background: Perinatal hypoxia-ischemia is a major cause of long-term neurological impairments in newborns, with ferroptosis recognized as a key mechanism of injury. Cannabidiol (CBD) is a non-psychoactive phytocannabinoid...
Spermidine alleviates ethanol-induced hepatocyte ferroptosis by restoring hepatic iron homeostasis via the gut-liver axis [0.03%]
spermidine通过肠肝轴恢复肝脏铁稳态来缓解乙醇诱导的肝细胞铁死亡
Yan-Jing Zhang,Dong Cheng,Wen-Huan Yao et al.
Yan-Jing Zhang et al.
Background & aims: Alcohol-related liver disease (ALD) remains a global public health challenge, highlighting the urgent need to uncover novel pathophysiological mechanisms and therapeutic targets. Spermidine, a natural p...
Phaseoloidin, a homogentisic acid glucoside from Entada phaseoloides, suppresses gout inflammation via NLRP3 inflammasome [0.03%]
来自Entada phaseoloides的均茵酸糖苷phaseoloidin通过NLRP3炎性小体抑制痛风炎症
Yin-Jing Jiang,Hao-Qing Zhu,Yong-Hong Cheng et al.
Yin-Jing Jiang et al.
Background: Gout is an arthritic disorder caused by the deposition of sodium urate crystals in the joints. Phaseoloidin (PHA), a β-glucoside of homogentisic acid isolated from the seeds of the legume "Entada phaseoloides...
Trigonelline regulates glycolysis and energy metabolism during hepatic fibrosis via Glut-1-HIF-1α axis: Focusing the interaction of macrophages and HSCs [0.03%]
trigonelline通过Glut-1-HIF-1α轴调节肝纤维化过程中的糖酵解和能量代谢：着重研究巨噬细胞与HSCs的相互作用
Chong Gao,Wei Liu,Sai-Hu Liu et al.
Chong Gao et al.
Background: Reprogramming of aerobic glycolysis occurs with HSCs activation and is associated with regression of liver fibrosis. Trigonelline (TRG), a plant alkaloid extracted from Trigonella foenum-graecum L seeds, has a...
From virtual screening to functional discovery: Apigenin ameliorates acute pancreatitis by targeting HINT2 to regulate the mitochondrial acetylome [0.03%]
从虚拟筛选到功能发现：通过靶向HINT2调节线粒体乙酰化组分发挥黄酮类化合物Apigenin改善急性胰腺炎的作用
Yang Peng,Jia-Qi Yao,Hong-Ying Li et al.
Yang Peng et al.
Background: Acute pancreatitis (AP) is a life-threatening inflammatory disorder with limited therapeutic options. The mitochondrial protein HINT2 has been identified as a promising therapeutic target, but specific agonist...
Arnicolide C induces ferroptosis in liver cancer through modulation of the HMOX1-TRC8 axis [0.03%]
Arnicolide C通过调节HMOX1-TRC8轴诱导肝癌细胞铁死亡
Xuqi Zhao,Jinrui Wei,Yuxin Xie et al.
Xuqi Zhao et al.
Liver cancer remains a significant therapeutic challenge, underscoring the urgent need for novel treatment strategies. Recently, induction of ferroptosis has emerged as a promising approach for treating malignant tumors. In this study, we i...
Typhaneoside suppresses osteoclastogenesis and osteoporosis by stabilizing ADORA1 [0.03%]
泰菲辛通过稳定ADORA1来抑制破骨细胞生成和治疗骨质疏松症
Shaoyan Shi,Yuan Liu,Yansheng Huang et al.
Shaoyan Shi et al.
Background: Osteoporosis, characterized by impaired bone remodeling and increased bone fragility, is increasingly prevalent among postmenopausal women. Current pharmacological treatments exhibit efficacy but are associate...
Natural product-mediated autophagy targeting for prostate cancer: A novel potential therapeutic strategy [0.03%]
天然产物介导的自噬靶向治疗前列腺癌：一种潜在的新疗法
Maofu Zhang,Jialin Zhong,Maobin Yu et al.
Maofu Zhang et al.
Background: Prostate cancer (PCa) is one of the most common malignancies among middle-aged and elderly men. It exhibits persistently high global incidence and mortality rates. Given the limitations of conventional treatme...
Puerarin 6″-O-xyloside improves postmenopausal lipid metabolic disorders via the PPARα-mediated FAO pathway [0.03%]
葛根素6″-O-木糖苷通过PPARα介导的脂肪酸氧化途径改善绝经后脂质代谢紊乱
Danna Wang,Yalin You,Tianyu Luo et al.
Danna Wang et al.
Background: Pueraria lobata (Willd.) has long been used in traditional medicine to alleviate menopausal symptoms and is commonly employed in clinical settings. Puerarin 6″-O-xyloside (P6OX), a naturally occurring isoflav...
Magnolia officinalis Rehder & E. Wilson extract and its main component honokiol alleviate asthma by reducing respiratory inflammation through the TRPV1/NFAT/TSLP pathway [0.03%]
杜仲提取物及其主要成分粗皮素通过TRPV1/NFAT/TSLP信号通路缓解哮喘作用机制研究
Liming Tu,Xiaoying Zhu,Meihao Peng et al.
Liming Tu et al.
Background: Asthma is a chronic respiratory disorder whose complexity presents significant challenges for effective treatment, necessitating ongoing innovation in therapeutic approaches. Magnolia officinalis Rehder & E. W...