Total glucosides of paeony ameliorates lupus nephritis by suppressing ZBP1-mediated PANoptosis in podocytes [0.03%]
芍药苷通过抑制足细胞中ZBP1介导的PANoptosis改善狼疮性肾炎
Yi Wang,Qian-Qian He,Yan-Ting Zhu et al.
Yi Wang et al.
Background: Lupus nephritis (LN), a severe complication of systemic lupus erythematosus (SLE), lacks effective therapies because of its complex pathogenesis. PANoptosis, an integrated cell death pathway that combines apop...
4-O-Demethylbarbatic acid has a novel therapeutic impact on the progression of EGFR-driven lung adenocarcinoma [0.03%]
4-O-去甲基巴巴酸对EGFR驱动的肺腺癌进展具有新的治疗作用
Mücahit Varlı,Rui Zhou,Rundong Liu et al.
Mücahit Varlı et al.
Background: 4-O-Demethylbarbatic acid (4O-DBA), a secondary metabolite derived from lichen species, has shown inhibitory activity of epstein-barr virus (EBV), indicating its potential in cancer prevention or treatment. Ho...
Keluoxin reduces renal lipid deposition in diabetic nephropathy via AMPK/NF-κB-mediated mtabolic regulation [0.03%]
千斤拔通过AMPK/NF-κB代谢调节减轻糖尿病肾病肾脏脂质沉积作用机制研究
Shan Zhang,Zhige Wen,Yupeng Chen et al.
Shan Zhang et al.
Background: Diabetic nephropathy (DN) is often accompanied by dysregulated lipid metabolism, which exacerbates renal injury. Keluoxin (KLX), a therapeutic agent approved by the National Medical Products Administration of ...
Theaflavin-3,3'-digallate stabilizes vulnerable plaques by reprogramming metabolic homeostasis in neovascularization via HK2/TIGAR [0.03%]
茶黄素-3,3'-二没食子酸通过HK2 / TIGAR重新编程新生血管代谢稳态来稳定易损斑块
Kuan Cen,YinFei Huang,Yu Xie et al.
Kuan Cen et al.
Background: The leakage of vasa vasorum (VV) and intraplaque hemorrhage (IPH) pose significant risk for the instability and rupture of atherosclerosis (AS) plaques. The development of novel herbal monomers for anti-AS the...
Selective PPARγ modulator alpinetin restores insulin sensitivity and protects from bone loss in type 2 diabetes [0.03%]
选择性PPARγ调节剂紫丁香茋可通过恢复胰岛素敏感性和防止骨量流失来治疗2型糖尿病并发症
Yaoyu Zhao,Hantao Yao,Yilin Liao et al.
Yaoyu Zhao et al.
Background: Type 2 diabetes mellitus (T2DM) poses a significant global health burden, with its escalating prevalence and related complications. Although peroxisome proliferator-activated receptor gamma (PPARγ) agonists s...
Prophylactic administration of Xuesaitong soft capsule ameliorating depression-like behaviors in rats after ischemic stroke by modulating metabolic disturbance [0.03%]
通心络胶囊通过调控代谢紊乱改善缺血性脑卒中大鼠抑郁样行为的二级预防作用研究
Rui Lu,Juan Yang,Ruoxi Fan et al.
Rui Lu et al.
Background: Post-stroke depression (PSD) exacerbates neurological disability, elevates suicide risk, and severely compromises survivors' quality of life and long-term prognosis. Current antidepressants exhibit suboptimal ...
Serum pharmacochemistry and network pharmacology reveal the effect and mechanism of licorice extracts on colorectal cancer [0.03%]
基于血清药物化学及网络药理学的甘草抗结直肠癌效应和机制研究
Yamei Li,Junya Wen,Kaili Deng et al.
Yamei Li et al.
Background: Colorectal cancer (CRC) is a prevalent malignant tumor. As per the principles of Traditional Chinese Medicine (TCM), the primary pathogenesis of CRC is associated with a deficiency in vital energy. Licorice, k...
Tangshen formula alleviates doxorubicin induced nephrotoxicity by regulating BAX crosstalk in podocyte [0.03%]
丹参配方通过调节足细胞中BAX交叉对话来缓解多柔比星引起的肾毒性
Yuxi Li,Ge Hong,Liang Peng et al.
Yuxi Li et al.
Background: Doxorubicin (DOX) is a widely used anticancer drug with a marked nephrotoxic effect. The Chinese medicine Tangshen Formula (TSF) has a kidney-protective effect in diabetic kidney disease patients and has been ...
Dihydrotanshinone I targets the spike N-terminal domain to inhibit SARS-CoV-2 entry and spike-induced inflammation [0.03%]
丹参素甲通过靶向刺突蛋白N端结构域抑制SARS-CoV-2的入侵及刺突诱导的炎症反应
Chan Yang,Kunyu Lu,Jinshen Wang et al.
Chan Yang et al.
Background: Despite progress made in addressing the COVID-19 pandemic, numerous challenges persist, including breakthrough infections (BTI) and reinfections with SARS-CoV-2. There is an urgent need for broad-spectrum anti...
Chaihu Shugan San formula alleviates psychological stress-induced ovarian cancer susceptibility by inhibiting ubiquitin degradation of TLR2 in macrophages [0.03%]
柴胡舒肝散通过抑制巨噬细胞中TLR2的泛素降解来缓解心理压力引起的卵巢癌易感性
Fang Wu,Yang Liu,Gan-Qing Luo et al.
Fang Wu et al.
Background: Psychological stress is increasingly recognized for its potential to expedite tumor growth and enhance cancer susceptibility, yet the specific mechanisms at play remain largely unclear. Traditional Chinese Med...