Asperosaponin VI enhances stress resilience by activating hippocampal neural stem cells [0.03%]
asperosaponin Ⅵ通过激活海马神经干细胞提高应激抵抗力
Yu-E Liu,Yan Fu,Juan Fu et al.
Yu-E Liu et al.
Background: Enhancing stress resilience through hippocampal neural stem cell (NSC) activation is a promising way to reduce depression risk. Earlier studies show that asperosaponin Ⅵ (ASA-VI) can efficiently cross the blo...
Celastrol induces ferroptosis in ccRCC through TEF-Driven ACOX2 upregulation and metabolic reprogramming [0.03%]
Celastrol通过TEF介导的ACOX2上调和代谢重编程诱导ccRCC铁死亡
Yijun Tian,Changjie Ren,Hongru Wang et al.
Yijun Tian et al.
Background: Celastrol, a bioactive triterpenoid from Tripterygium wilfordii, exhibits antitumor properties across multiple malignancies, while the molecular mechanisms linking it to metabolic regulation and ferroptosis in...
Coniferyl aldehyde in ginger-Eucommiae Cortex enhances osteoarthritis treatment by modulating ALDOA and H3K23la histone lactylation [0.03%]
姜皮中香豆醛茋通过调节ALDOA和H3K23la乳酰化增强骨关节炎治疗效果
Yijing Pan,Xinyue Liu,Shunshun Wang et al.
Yijing Pan et al.
Background and purpose: Eucommiae Cortex (EC), a traditional Chinese medicinal herb, has been utilized to treat osteoarthritis (OA). The therapeutic efficacy of EC can be augmented by combining it with ginger juice. OA is...
Sinomenine inhibits oxidative stress to attenuate Alzheimer's disease pathology via α7 nicotinic acetylcholine receptor [0.03%]
延胡索碱通过α7胆碱能受体抑制氧化应激以缓解阿尔茨海默病病理症状
Haojie Ni,Yiyi Xiong,Min Liu et al.
Haojie Ni et al.
Background: The pathological mechanism of Alzheimer's disease (AD) is complex. The binding of Aβ to α7 nicotinic acetylcholine receptor (α7nAChR) contributes to neuronal damage. Sinomenine (SIN) is an alkaloid extracte...
Corrigendum to "Astragalus licorice prescription and its active components alleviate chemotherapy-induced intestinal mucositis by apoptosis and fatty acid β-oxidation: Integrative multi-omics approaches" [Phytomedicine, 150 (2026) 157734] [0.03%]
甘草黄耆汤及其活性成分通过凋亡和脂肪酸β氧化缓解化疗引起的肠黏膜炎：整合多组学方法的补充更正“甘草黄耆汤及其活性成分通过凋亡和脂肪酸β氧化缓解化疗引起的肠黏膜炎：整合多组学方法”
Xiaoqian Wang,Yuemei Zhang,Jinhan Wu et al.
Xiaoqian Wang et al.
Gentiopicroside attenuates lupus arthritis by targeting galectin-mediated macrophage activation [0.03%]
苦地丁素通过靶向半乳糖凝集素介导的巨噬细胞活化治疗狼疮性关节炎
Yihong Gan,Shihui Zhou,Ke Lin et al.
Yihong Gan et al.
Background: Inflammatory arthritis represents a common and clinically challenging manifestation of systemic lupus erythematosus (SLE), with current therapeutic options often exhibiting limited efficacy. ...
Functional calibration of PPARγ by baicalein reverses bone-lipid imbalance in type 2 diabetic osteoporosis [0.03%]
黄芩素功能性激活PPARγ逆转2型糖尿病骨脂代谢失衡效应
Hua Zhang,Bai Hao Chen,Jianan Huang et al.
Hua Zhang et al.
Background: Type 2 diabetic osteoporosis (T2DOP) is characterized by excessive bone marrow adiposity and impaired osteogenesis, a pathology driven primarily by PPARγ-mediated dysregulation of the osteogenic-adipogenic di...
Dendrobium polysaccharides ameliorate alcohol-induced liver injury by inhibiting the pathogenic ER stress-sphingolipid axis [0.03%]
石斛多糖通过抑制病理性内质网应激-鞘脂信号轴改善酒精性肝损伤
Jiawei Ling,Ziwei Han,Junjie Qiu et al.
Jiawei Ling et al.
Background: Alcohol-associated liver disease (ALD) is a major global health burden with incompletely understood molecular mechanisms. Endoplasmic reticulum stress (ERS) and sphingolipid dysregulation contribute to ALD, bu...
Nelumbo nucifera extract alleviates UVB-induced hyperpigmentation via NOX4-mediated AMPK-YAP-ATG5 signaling pathway [0.03%]
莲子叶提取物通过NOX4介导的AMPK-YAP-ATG5信号通路缓解UVB诱导的色素沉着
Cailing Wen,Jiaying Li,Canye Li et al.
Cailing Wen et al.
Background: Hyperpigmentation is primarily caused by ultraviolet (UV) radiation, which triggers oxidative stress and melanin accumulation in the skin. Moderate UVB exposure activates autophagy, which facilitates cell repa...
Exploring the role of curcumin in anti-atherosclerosis: Mechanisms and pathways of action [0.03%]
姜黄素抗动脉粥样硬化作用的研究进展：机制与作用途径探索
Lijun Zhou,Xinyue Wang,Chuchuan Meng et al.
Lijun Zhou et al.
Background: Atherosclerosis (AS), a chronic inflammatory disease, remains a leading cause of cardiovascular morbidity. Curcumin, the primary bioactive compound from Curcuma longa, has demonstrated potent anti-atherosclero...