Structure-affinity driven repurposing of natural compounds and herbal prescriptions for ulcerative colitis and psoriasis [0.03%]
结构-亲和力驱动的天然化合物和中药复方的老药新用研究溃疡性结肠炎和银屑病
Rui Tian,Ting Hu,Jinyuan Chang et al.
Rui Tian et al.
Background: Psoriasis and ulcerative colitis (UC) are immune-mediated chronic inflammatory diseases that affect barrier organs and share significant overlap in both pathogenesis and treatment strategies. Although the adve...
Corrigendum to "Kaempferol combats the osteogenic differentiation damage of periodontal ligament stem cells in periodontitis via regulating EphrinB2-mediated PI3K/Akt and P38 pathways" [Phytomedicine, 141 (2025) 156733] [0.03%]
关于“ kaempferol通过调节EphrinB2介导的PI3K/Akt和P38途径对抗牙周炎中牙周膜干细胞成骨分化损伤”的勘误[Phytomedicine, 141 (2025) 156733]
Jiao Cao,Yue Li,Mengying Si et al.
Jiao Cao et al.
The HIF-1α signaling pathway: A key approach to revealing the effects of Scutellaria baicalensis Georgi against lipopolysaccharide-induced spontaneous abortion [0.03%]
Baicalin通过HIF-1α信号通路对抗LPS致小鼠自发性流产的作用及机制研究
Jing-Xin Gao,Mei-Ying Yue,Jin-Zhu Huang et al.
Jing-Xin Gao et al.
Background: Scutellaria baicalensis Georgi (SBG) is traditionally used to prevent miscarriage through its anti-inflammatory, antioxidant, and antiapoptotic effects. However, its mechanisms in early-stage abortion (ESA) re...
Gan-Mai-Da-Zao decoction ameliorates depressive-like behaviors in CUMS mice via the microbiota-metabolism-inflammation axis [0.03%]
甘麦大枣汤通过肠-代谢-免疫轴缓解慢性束缚应激小鼠的抑郁样行为
Biqun Zhang,Jiaqi Ji,Xuesong Zhang et al.
Biqun Zhang et al.
Background: Gan-Mai-Da-Zao decoction (GMDZ), a traditional Chinese formulation used as both food and medicines, exhibits antidepressant effects. However, its underlying mechanisms, particularly those involving the gut-bra...
Tanshinone I alleviates post-ischemic myocardial injury by targeting TGFBR1 and modulating the TGF-β signaling pathway [0.03%]
丹参酮I通过靶向TGFBR1并调节TGF-β信号通路来缓解缺血后心肌损伤
Liyuan Ke,Ziyao Zheng,Shumin Ye et al.
Liyuan Ke et al.
Background: Tanshinone I (Tan I) is an essential active ingredient of the traditional cardiovascular medicine Salvia miltiorrhiza Bunge (S. miltiorrhiza). Although the protection of Tan I on cardiomyocyte has been reporte...
Activation of BDNF-TrkB-PI3K-AKT signaling pathway by Tong-Qiao-Huo-Xue Decoction facilitates nerve regeneration and mitigates cerebral ischemia-reperfusion injury [0.03%]
通窍活血汤通过激活BDNF-TrkB-PI3K-AKT信号途径促进神经再生及减轻脑缺血再灌注损伤
Yuqin Peng,Hao Sun,Fan Xu et al.
Yuqin Peng et al.
Background: Nerve regeneration is an important manifestation of self-repair mechanism after stroke. Tong-Qiao-Huo-Xue Decoction (TQHXD) has significant neuroprotective effects, but whether this effect is related to promot...
HDAC/NF-κB signaling pathway mediates gut microbiota dysbiosis in rheumatoid arthritis: Intervention mechanisms of Fengshining decoction [0.03%]
风湿宁汤干预类风湿关节炎肠道微生态失衡及NF-κB信号通路的作用机制研究
Ya Wen,Mingyang Li,Yuanhui Hao et al.
Ya Wen et al.
Background: Gut microbiota dysbiosis has been associated with the development of rheumatoid arthritis (RA). Fengshining (FSN) is a traditional Chinese medicine decoction that can effectively alleviate RA. However, how FSN...
Ovatodiolide alleviates renal fibrosis through regulating metabolic reprogramming via targeting glucose-6-phosphate dehydrogenase [0.03%]
卵泡酮通过靶向葡萄糖-6-磷酸脱氢酶调节代谢重编程从而缓解肾纤维化
Xiaoyang He,Xiaowen Chen,Wenting Wu et al.
Xiaoyang He et al.
Background: Ovatodiolide (Ova) is a bioactive compound from Anisomeles indica (l.) Kuntze, which has been traditionally utilized to tonify the kidney function. There is limited targeted therapies available for renal fibro...
Jiangu formula modulates the gut microbiota structure and the NF-κB/NLRP3 signaling pathway to alleviate synovitis [0.03%]
健骨方通过调节肠道菌群结构及NF-κB/NLRP3信号通路改善滑膜炎
Shuying Li,Aoyu Zhang,Jie Qiao et al.
Shuying Li et al.
Background: Synovitis is a pivotal pathological hallmark of arthritis, and timely intervention is essential for mitigating joint degeneration. Jiangu formula (JGF) can reduce inflammation in joint synovial fluid. However,...
Therapeutic mechanisms of Acorus tatarinowii and its bioactive compounds in cardiovascular diseases: A comprehensive review [0.03%]
石菖蒲及其活性成分治疗心血管疾病的机制研究：综述文章
Yuting Qiu,Peng Zhao,Lin Xu et al.
Yuting Qiu et al.
Background: Cardiovascular diseases (CVDs) are the leading cause of global morbidity and mortality, imposing significant healthcare and economic burdens. Despite advances in treatment, current therapies have limitations t...