Tripterygium glycosides reverse cisplatin resistance in epithelial ovarian cancer by activating ferroptosis via two different pathways [0.03%]
三羟基茋逆转顺铂耐药的卵巢癌的分子机制研究：诱导铁死亡的新功能及其作用机制
Xiaoyun Wu,Wan Peng,Qianyu Yong et al.
Xiaoyun Wu et al.
Background: In our previous study, tripterygium glycosides (TG) demonstrated to combine with cisplatin (DDP) in reversing DDP resistance in A2780/DDP cells by exacerbating ferroptosis via downregulation of glutathione per...
Shikonin ameliorates renal fibrosis by targeting HSPA1A to regulate lipid metabolism and inhibit ferroptosis [0.03%]
Shoqing Pill alleviates renal fibrosis by targeting HSPALAA to regulate lipid metabolism and inhibit ferroptosis
Zhirui Zhang,Meijuan Zhang,Lili Chen et al.
Zhirui Zhang et al.
Background: Renal fibrosis (RF) is a critical step in the progression of chronic kidney disease to end-stage renal failure, but its treatment remains highly challenging, highlighting the urgent clinical need for novel the...
Herbal-derived puerarin-berberine cocrystal: Computational insights into mechanisms driving simultaneous enhanced solubility and bioavailability [0.03%]
来源于草药的染料木黄酮-小檗碱共晶：计算阐明同时增强溶解度和生物利用度的机制见解
Liang Li,Pengfei Liu,Chang Zhang et al.
Liang Li et al.
Background: Ge-Gen-Huang-Lian Decoction (GGHLD) is a traditional Chinese herbal formula with diverse pharmacological effects, primarily attributed to puerarin (PUE, from Pueraria lobata) and berberine (BER, from Coptidis ...
Inhibition of influenza a virus infection by natural isoquinoline alkaloid neferine targeting virus nucleoprotein [0.03%]
靶向病毒核蛋白抑制流感病毒的天然异喹啉生物碱宁波素的研究
Xiaoyao Ma,Yang Zhang,Lishan Sun et al.
Xiaoyao Ma et al.
Background: Influenza A virus (IAV) poses a serious threat to human health, and the increasing problem of drug resistance, along with the emergence of highly pathogenic strains, makes the development of new antiviral drug...
Atractyloside-A ameliorates spleen deficiency diarrhea in mice via modulating Lactobacillus johnsonii-butyric acid-GPR43 axis and NF-κB -NLRP3 signaling pathway [0.03%]
乌术散A通过调节乳酸菌johnsonii-丁酸-GPR43轴和NF-κB-NLRP3信号通路改善脾虚泄泻小鼠模型的症状
Yangxin Xiao,Chang Ke,Dongpeng Wang et al.
Yangxin Xiao et al.
Background: Spleen deficiency diarrhea (SDD) is regarded as a common gastrointestinal dysfunction in Traditional Chinese Medicine (TCM), which may lead to intestinal barrier damage and trigger intestinal inflammation. Pre...
Isoginkgetin inhibits non-small cell lung cancer by inducing oxidative stress and regulating M1 macrophage polarization [0.03%]
异甘草素通过诱导氧化应激和调节M1型巨噬细胞极化抑制非小细胞肺癌的作用研究
Chunyang Zhu,Fengyan Zhang,Xueni Li et al.
Chunyang Zhu et al.
Background: Non-small cell lung cancer (NSCLC), which constitutes approximately 85% of all lung cancer cases, is a leading cause of cancer mortality worldwide. Isoginkgetin (ISO), a biflavonoid isolated from Ginkgo biloba...
Vincamine as a GPR40 agonist shows potential in treating female Alzheimer's disease [0.03%]
Vinamarine通过GPR40发挥激动剂作用对女性阿尔茨海默病具有潜在治疗效果
Jianlu Lyu,Danyang Zhu,Ze Wang et al.
Jianlu Lyu et al.
Background: Women face a heightened risk of Alzheimer's disease (AD), partly attributed to post-menopausal estrogen loss. Given that ERβ activation avoids the oncogenic risks of ERα and GPR40 plays a pivotal role in neu...
Integration of network pharmacology and gut microbiota analysis to uncover the molecular mechanisms of Zengye decoction against slow transit constipation [0.03%]
基于网络药理学和肠道菌群分析的增液汤治疗慢传输型便秘分子机制研究
Rong Wu,Qingxia Xu,Yong Wen et al.
Rong Wu et al.
Background: Slow-transit constipation (STC) is the predominant type of functional constipation, and Zengye decoction (ZYD) has been widely used in clinical practice. ...
Spatial metabolomics combined with MALDI-MSI unveils gut-brain axis mechanisms of angelica dahurica radix in migraine rats [0.03%]
基于空间代谢组学的当归防风汤治疗偏头痛的作用机制研究
Yan Lian,Xiang Chen,Xile Shen et al.
Yan Lian et al.
Background: Migraine is a highly disabling neurological disorder characterized by recurrent headaches and complex metabolic disturbances, affecting approximately 15% of the global population. Angelica dahurica Radix (Baiz...
Restoration of meropenem efficacy against multidrug-resistant Acinetobacter baumannii by green tea polyphenol EGCG: Dual targeting of efflux and porin pathways [0.03%]
绿茶儿茶素EGCG恢复美罗培南对多重耐药阿氏baumanii活性：针对外排和孔蛋白的双重作用机制
Zijian Liang,Xiaoxu Chen,Ivanhoe K H Leung et al.
Zijian Liang et al.
Background: Acinetobacter baumannii is a Gram-negative bacterial pathogen responsible for severe nosocomial infections. Carbapenems, including meropenem and imipenem, are β-lactam antibiotics commonly used as a last-reso...