The protective mechanism of Hydroxysafflor yellow A for the treatment of stroke - heart - syndrome via activating the ZBP1-NLRP3 signaling pathway [0.03%]
羟基红花黄色素A通过激活ZBP1-NLRP3信号通路治疗脑心综合征的保护机制研究
Chaowen Ge,Hao Sun,Ning Wang et al.
Chaowen Ge et al.
Background: Hydroxysafflor yellow A (HSYA), the primary active constituent of Safflower, a traditional Chinese medicine, has demonstrated promising therapeutic potential in the treatment of cardiovascular and cerebrovascu...
Traditional Chinese medicine protects against doxorubicin cardiotoxicity via epigenetic modification and beyond [0.03%]
基于表观遗传调控的中药防治多柔比星心肌毒性的研究进展
Jingquan Zhou,Huan Liu,Feng Jiang et al.
Jingquan Zhou et al.
Background: Doxorubicin (DOX), a cornerstone chemotherapeutic agent, is plagued by dose-dependent cardiotoxicity that compromises its clinical utility. Despite advances in understanding DOX-induced cardiotoxicity (DIC), e...
Isoliquiritigenin alleviates abnormal sarcomere contraction and inflammation in myofascial trigger points via the IL-17RA/Act1/p38 pathway in rats [0.03%]
isoliquiritigenin通过IL-17RA/Act1/p38信号通路缓解肌筋膜触发点异常横桥循环和炎症的机制研究
Xuan Li,Tian Qi,Lingwei Zhou et al.
Xuan Li et al.
Background: Myofascial trigger points (MTrPs) are a primary cause of myofascial pain syndrome. Current studies suggest that MTrPs consist of persistent sarcomere contraction and an inflammatory microenvironment. IL-17 has...
Taraxerol induces ferroptosis in breast cancer by targeting Nrf2 transcriptional activity to promote MIB2-mediated GPX4 ubiquitination [0.03%]
大牻牛儿素通过靶向Nrf2转录活性诱导乳腺癌细胞铁死亡并促进MIB2介导的GPX4泛素化降解
Pan Du,Anna Han,Jiajing Liu et al.
Pan Du et al.
Background: Eradicating tumors through targeted ferroptosis represents a novel approach to BC treatment. Taraxerol, a natural triterpenoid derived from dandelions, has shown anti-tumor effects. However, the ferroptosis de...
Shoutai pill exhibits anti-miscarriage efficacy through tripartite modulation of gut microbiota, systemic metabolism, and maternal-fetal immunity: A multi-omics analysis [0.03%]
少腹逐瘀丸通过三位一体调节肠道菌群、系统代谢及母胎免疫达到保胎功效：多组学分析研究
Wanfeng Xu,Bo Li,Zhihao Ge et al.
Wanfeng Xu et al.
Background: Shoutai pill (STP)-a classical Chinese herbal formula-is clinically used to manage miscarriage, albeit its bioactive constituents and pharmacological mechanisms are not incompletely characterized. ...
Cucurbitacin B stimulates PD-1 immunotherapy response in malignant breast cancer by covalent targeting MTCH2 [0.03%]
cucurbitacin B通过共价靶向MTCH2促进恶性乳腺癌的PD-1免疫治疗反应
Qianqian Xu,Zeyu Jiang,Yuqi Pan et al.
Qianqian Xu et al.
Background: Effective therapies for malignant breast cancer are urgently needed, as resistance and immunosuppressive microenvironments limit PD-1 blockade efficacy. The natural product Cucurbitacin B (CuB) reportedly sens...
Multi-omics analysis of the active components and mechanisms of Baojin Chenfei formula in silica-induced murine silicosis [0.03%]
宝金尘肺方治疗硅酸盐诱导的小鼠矽肺的多组学分析及其机制研究
He Wr,Lu Yq,Liu Xg et al.
He Wr et al.
Background: Silicosis is a severe fibrotic lung disease resulting from exposure to silica, with limited therapeutic options despite recent advances. The Baojin Chenfei Formula (BCF), a traditional Chinese medicine, has sh...
Cannabidiol attenuates methamphetamine-induced oxidative neurotoxicity via regulating transient receptor potential vanilloid type 1 [0.03%]
大麻二酚通过调节瞬时受体电位香草素型1减轻甲基苯丙胺致氧化神经毒性作用
Baoyu Shen,Genmeng Yang,Mengran Lv et al.
Baoyu Shen et al.
Background: The prevalence of methamphetamine (METH) abuse has significantly escalated in many regions worldwide. Despite this increase, the complexity of neurotoxicity associated with METH is inadequately understood. Can...
Alisol B ameliorated metabolic dysfunction-associated steatotic liver disease via regulating purine metabolism and restoring the gut microbiota disorders [0.03%]
alisol B通过调节嘌呤代谢和恢复肠道菌群紊乱来改善与代谢功能障碍相关的脂肪变性肝病
Lin Yiyou,Zhang Congcong,Ren Guilin et al.
Lin Yiyou et al.
Background: Alisol B (AB) has been demonstrated to be a potential lead compound in improving obesity-related metabolic disorders. Nevertheless, the effects and mechanisms of AB on Metabolic dysfunction-associated steatoti...
Parishin from Gastrodia elata ameliorates DSS induced colitis and anxiety-like behavior in mice by regulating intestinal barrier function and microviota-gut-brain axis [0.03%]
天麻石密苷通过调节肠道屏障功能及肠-微生态-脑轴改善小鼠结肠炎及其相关焦虑样行为
Xiaoxue Liu,Hejiang Zhou,Na Yang et al.
Xiaoxue Liu et al.
Background: Inflammatory bowel diseases (IBDs), including colitis, are commonly associated with dysfunctional intestinal barriers and dysregulated gut microbiota. Moreover, current medications for IBD cause serious side e...