Paeonol alleviates pulmonary arterial hypertension by activation of BRCC3 [0.03%]
芍药醇通过激活BRCC3缓解肺动脉高压
Qing Yin,Zhengqin Xiong,Xinya Wang et al.
Qing Yin et al.
Background: Pulmonary arterial hypertension (PAH) is characterized by vascular remodeling and right ventricular failure. Paeonol, a bioactive compound extracted from the root bark of Paeonia suffruticosa, exhibits anti-in...
Quercetin targets IL6/JAK1/STAT3/MMP9 signaling to attenuate breast cancer progression in diabetic comorbidity: A multi-omics and experimental study [0.03%]
芦丁靶向IL6/JAK1/STAT3/MMP9信号轴以减轻糖尿病合并乳腺癌进展：多组学和实验研究
Siyu Liu,Dandan Feng,Yuhao Xu et al.
Siyu Liu et al.
Background: Breast cancer and diabetes exhibit a bidirectional relationship, with diabetes elevating breast cancer risk/mortality and cancer therapies potentially increasing diabetic susceptibility. While the natural flav...
Corrigendum to "Effusol ameliorates ischemic stroke by targeting NLRP3 protein to regulate NLRP3 inflammasome-mediated pyroptosis" [Phytomedicine, 136 (2025) 156253/PMID: 39615210] [0.03%]
“Effusol通过靶向NLRP3蛋白调节NLRP3炎性小体介导的细胞焦亡改善缺血性卒中”的勘误页 [Phytomedicine, 136 (2025) 156253/PMID: 39615210]
Libin Xu,Siyu Li,Jiaxin Qi et al.
Libin Xu et al.
Qingfei Jiedu Huatan formula protects against pneumonia by activating Nrf2 to suppress alveolar epithelial apoptosis [0.03%]
清肺解毒化痰方通过激活Nrf2抑制肺泡上皮细胞凋亡来防治肺炎
Yuhang Jiang,Qin Zhang,Yumeng Cheng et al.
Yuhang Jiang et al.
Background: Qingfei Jiedu Huatan Formula (QJHF) has demonstrated efficacy in reducing the clinical stabilization time for pneumonia patients, decreasing ICU durations, and enhancing patients' quality of life. ...
Enhanced bioavailability of anemoside B4 by dry powder inhalation mitigates high-altitude acute lung injury [0.03%]
天门冬素B4吸入给药改善高海拔肺损伤作用及机制研究
Yuewen Wen,Yupu Teng,Shiyu Zheng et al.
Yuewen Wen et al.
Background: Anemoside B4 (AB4), a pentacyclic triterpenoid saponin, exhibits potent anti-inflammatory and antioxidant activities; however, it has poor oral bioavailability. Hypobaric hypoxia (HH) can induce high-altitude ...
Magnolol inhibits the resistance of ESBLs E. coli to fourth-generation cephalosporins in vitro and in vivo [0.03%]
Magnolol抑制ESBLs大肠埃希氏菌第四代头孢菌素耐药性的作用及机制研究
Yin-Chao Tong,Huan Lin,Yang Yang et al.
Yin-Chao Tong et al.
Background: Antimicrobial resistance (AMR) infection is attracting increasing attention, especially superbug infections. As a result, finding ways to reduce AMR is essential. For the time being, natural compound therapy f...
Salvia miltiorrhiza Bunge promotes osteogenesis and angiogenesis by activating HIF-1α/VEGF and Slit3 pathways [0.03%]
丹参促进骨生成和血管生成通过激活HIF-1α/VEGF及Slit3途径
Gaiyue Yue,Shan Wang,Xuan Dai et al.
Gaiyue Yue et al.
Background: Osteogenesis and angiogenesis are closely coupled during bone modeling and remodeling, providing a potential direction for treating osteoporosis. Salvia miltiorrhiza Bunge (SM) has been preclinically and clini...
American ginseng-derived extracellular vesicle-like nanoparticles (AGELNs) mitigate doxorubicin-induced cardiotoxicity by inhibiting GPX4-mediated ferroptosis [0.03%]
从美国人参中获得的类似细胞外囊泡的纳米颗粒通过抑制GPX4介导的铁死亡来缓解多柔比星引起的心脏毒性
Teng Liu,Huan Wang,Ruifen Wang et al.
Teng Liu et al.
Background: Panacis Quinquefolii Radix (American ginseng, AG) has a well-documented history of use in cardiac protection. Nevertheless, the therapeutically active components responsible for its cardioprotective properties...
Shen-Shuai-Ⅱ Recipe ameliorates chronic kidney disease-induced myocardial injury via inhibition of the IL-18/IL-18R1/MyD88 pathway [0.03%]
参术-II方通过抑制IL-18/IL-18R1/MyD88信号通路改善慢性肾脏病诱导的心肌损伤处方
Lingchen Wang,Yufeng Xing,Shengchun Liao et al.
Lingchen Wang et al.
Background: Chronic kidney disease (CKD) is a significant risk factor for myocardial injury. Despite the proven clinical safety and efficacy of Shen Shuai II Recipe (SSR) in CKD management, and evidence of its renoprotect...
Cistanche tubulosa phenylethanol glycoside liposome ameliorates oxaliplatin-induced peripheral neuropathy by promoting RNA N6-methyladenosine modification [0.03%]
肉苁蓉苯乙醇苷脂质体通过促进RNA N6-甲基腺苷修饰缓解奥沙利铂外周神经毒性
Yatan Li,Xuexian Ma,Yujie Zeng et al.
Yatan Li et al.
Background: Oxaliplatin-induced peripheral neuropathy (OIPN) is a frequent dose-limiting toxicity in cancer treatment, with no effective FDA-approved therapy available. Dysregulated RNA N6-methyladenosine (m6A) modificati...