Decoding the anti-heart failure effects of Xinbao Pills: AMPKα1 activation and active compound screening [0.03%]
新宝丸抗心衰作用机制及活性成分筛选的研究：AMPKα1激活途径
Zunjiang Li,Yingxin Long,Xing Sun et al.
Zunjiang Li et al.
Background: Previous studies have focused on the protective effect of Xinbao pills (XBP) on heart failure (HF) irrespective of the ejection fraction-based classification, However, there are still no reports on the mechani...
Ethanol extract of Periploca forrestii Schltr. and chlorogenic acid alleviate ischemic stroke by inhibiting TLR4-mediated neuroinflammation [0.03%]
福神曲总提取物和绿原酸通过抑制TLR4介导的神经炎症改善缺血性脑卒中
Wenze Wu,Libin Xu,Lu Sun et al.
Wenze Wu et al.
Background: Neuroinflammation is a major factor in the pathogenesis of cerebral ischemia-reperfusion injury (CIRI). Periploca forrestii Schltr., commonly known as Heiguteng (HGT) in China, is a traditional anti-inflammato...
A novel triterpenoid saponin from Pimpinella candolleana alleviates postmenopausal osteoporosis via P38/JNK MAPK-mediated osteogenesis [0.03%]
新木犀草素通过P38 / JNK MAPK介导的成骨作用缓解绝经后骨质疏松症
Jiajia Wu,Zhen Cao,Chuyin Ou et al.
Jiajia Wu et al.
Bacground: Postmenopausal osteoporosis (PMOP) involves reduced bone mass and disrupted microarchitecture. Promoting osteoblast differentiation is a key therapeutic strategy. Pimpinella candolleana is a traditional Chinese...
Dihydrotanshinone I inhibits ovarian tumor growth by suppressing ITGB1/FAK-mediated extracellular matrix signaling [0.03%]
丹参素I通过抑制ITGB1/FAK介导的细胞外基质信号传导来抑制卵巢肿瘤生长
Bing Han,Chengtao Sun,Ruiwen Yang et al.
Bing Han et al.
Background: Ovarian cancer is a major lethal malignancy of the female reproductive system. Dihydrotanshinone I (DHT) is a tanshinone compound derived from Salvia miltiorrhiza and possesses significant anti-ovarian cancer ...
Salidroside alleviates bone cancer pain by inhibiting Th17/Treg imbalance through the AMPK/SIRT1 pathway [0.03%]
红景天苷通过AMPK/SIRT1信号通路改善骨癌痛的炎性微环境发挥镇痛作用研究
Kesong Zheng,Chengwei Yang,Mingming Han et al.
Kesong Zheng et al.
Background: Bone cancer pain (BCP) remains a significant clinical challenge with poorly understood mechanisms. While Th17 and Treg cells have been implicated in pain pathways, their specific roles in BCP pathogenesis requ...
Cryptotanshinone attenuates lactate-induced nucleus pulposus cells injury by modulating the STAT3/SIRT3 signaling axis [0.03%]
cryptotanshinone通过调节STAT3/SIRT3信号轴缓解乳酸诱导的椎间盘髓核细胞损伤
Jia-Jie Lu,Qi-Chen Zhang,Yi-Tuo Chen et al.
Jia-Jie Lu et al.
Introduction: Intervertebral disc degeneration (IVDD) stands out as one of the prevalent root causes of low back pain (LBP). In degenerated discs, the dysregulation of glucose metabolism and the impairment of nutrient tra...
Vitis labruscana Bailey leaf extract improves vascular function markers including platelet aggregation: A randomized, double-blind, placebo-controlled trial [0.03%]
越橘叶提取物对血管功能标志物（包括血小板聚集）的影响：一项随机、双盲、安慰剂对照试验
Eun-Soo Jung,Min-Jun Choi,Su-Jin Jung et al.
Eun-Soo Jung et al.
Background: Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Platelet aggregation plays a key role in thrombosis, a major contributor to CVD. Previous animal studies suggest that Vitis labruscana B...
Huotan Jiedu Tongluo Decoction targets Nrf2-mediated macrophage autophagy to inhibit ferroptosis and reduce atherosclerotic lesions [0.03%]
活坦解毒通络方通过NRF2介导的巨噬细胞自噬抑制铁死亡以减少动脉粥样硬化病变
Di Gao,Tenghui Tian,Keying Yu et al.
Di Gao et al.
Background: Atherosclerosis (AS) serves as a fundamental pathological basis for cardiovascular diseases (CVDs), with its progression intimately linked to ferroptosis-mediated disruptions in intracellular iron homeostasis ...
Dihydrotanshinone I, a main compound of Salvia miltiorrhiza, alleviates autoimmune and inflammatory diseases by directly targeting IRF3 [0.03%]
丹参茋类成分二氢丹参素甲通过直接抑制IRF3信号通路治疗自身免疫及炎症疾病
Wei Shi,Jincai Wen,Yuan Gao et al.
Wei Shi et al.
Background: Interferon regulatory factor 3 (IRF3) is an essential component of the immune system to protect the host from aggression, but excessive IRF3 activation leads to the release of type I interferon, interferon-sti...
Naringenin exerts antiarrhythmic action in septic cardiomyopathy by downregulating the CaMKⅡ/Drp1/Bcl-2 pathway [0.03%]
芸香素通过下调CaMKⅡ/Drp1/Bcl-2通路对Septic心肌病发挥抗心律失常作用
Yali Zhang,Yu Zhang,Hongmei Deng et al.
Yali Zhang et al.
Background: Septic cardiomyopathy (SCM) is associated with sepsis and is often accompanied by progressive arrhythmia. Naringenin (Nar) is a natural dihydroflavonoid compound that plays a protective role in various cardiov...