Integrated metabolomics and network pharmacology analysis of Yulan Jiangtang capsules in diabetic nephropathy [0.03%]
基于郁蓝降糖胶囊治疗糖尿病肾病的整合代谢组学与网络药理学分析
Xiaochun Zheng,Lan Xie,Haoran Xu et al.
Xiaochun Zheng et al.
Background: Diabetic nephropathy (DN), a serious diabetic complication, currently has limited treatment options. Yulan Jiangtang capsules (YL) are a clinically approved traditional Chinese medicine formula for glycemic co...
Evidences for the mechanism of anti-inflammatory effect of coptisine acting against clarithromycin-resistant Helicobacter pylori [0.03%]
黄连素抗耐克拉霉素幽门螺杆菌感染的抗炎作用机制研究证据
Qin Tang,Xiaoduo Li,Baihua Jiao et al.
Qin Tang et al.
Background: Previous studies have shown that coptisine (COP), a benzyl tetrahydroisoquinoline alkaloid isolated from Coptis chinensis, exhibits antibacterial activity against H. pylori. Furthermore, COP shows a low tenden...
Bruceine A ameliorates ulcerative colitis via macrophage polarization: Targeting HSP90-mediated IL-17 signaling and NF-κB activation [0.03%]
Bruceine A通过巨噬细胞极化改善溃疡性结肠炎：靶向HSP90介导的IL-17信号和NF-κB激活
Jiazhen Wu,Huiyuan Zeng,Chi Zhang et al.
Jiazhen Wu et al.
Background: Bruceine A (BA), a natural quassinoid compound derived from the fruit of Brucea javanica, has demonstrated diverse pharmacological activities. However, the treatment effectiveness of BA against ulcerative coli...
Brunodelphinine A alleviates non-alcoholic fatty liver disease by inhibiting oxidative stress and regulating lipid metabolism via NOX4/SIRT1/PPARs axis [0.03%]
溴代德尔菲宁A通过NOX4/SIRT1/PPARs轴抑制氧化应激及调节脂质代谢从而改善非酒精性脂肪肝病
Meiqi Wang,Beixuan Yang,Xin Li et al.
Meiqi Wang et al.
Background: Nonalcoholic fatty liver disease (NAFLD), which is characterized by the accumulation of fat in the liver, has emerged as a leading cause of chronic liver diseases and malignancies. However, there remains a sca...
Yuzhi Zhixue Granules regulate the JAK/STAT pathway to affect T-cell differentiation in the colon of ulcerative colitis [0.03%]
玉脂智雪颗粒通过调节JAK/STAT信号通路影响溃疡性结肠炎患者结肠T细胞分化的作用机制研究
Yifan Zhang,Chenxin He,Yusheng Zhao et al.
Yifan Zhang et al.
Purpose: Yuzhi Zhixue (YZZX) granules, a classic Chinese herbal remedy, have demonstrated efficacy in managing hemorrhagic and inflammatory conditions, and are clinically used to treat uterine bleeding. Building upon thei...
Quercetin ameliorates renal injury by promoting UCP1-mediated alleviation of lipid accumulation in diabetic kidney disease [0.03%]
檞皮素通过促进UCP1介导的脂质积累减轻糖尿病肾脏疾病损伤
Wei Yong,Ziyi Li,Weilong Xu et al.
Wei Yong et al.
Background: Diabetic kidney disease (DKD) represents a common microvascular complication associated with diabetes. Research suggests that lipid accumulation contributes to lipotoxicity, exacerbating kidney injury in DKD. ...
Gastrodin ameliorates ulcerative colitis via modulating gut microbial tryptophan metabolism and AhR/NLRP3 pathway [0.03%]
姜半夏多酚通过调节肠道微生物色氨酸代谢和AhR/NLRP3信号通路治疗溃疡性结肠炎
Dandan Zhang,Jinlu Wu,Hui Feng et al.
Dandan Zhang et al.
Background: Ulcerative colitis (UC), a chronic idiopathic inflammatory bowel disorder, presents persistent therapeutic challenges in clinical management. Gastrodin (GAS) is an active compound isolated from traditional Chi...
Corrigendum to "Wuse-oil Compound 03 mitigates radiation-induced oral mucositis by modulating oral microbiota to mediate TLR4/NF-κB pathway and inhibit M1 macrophage polarization" [Phytomedicine volume 145 (2025) Start page-End page/157083] [0.03%]
关于“吴苏油复合物03通过调节口腔微生物群来介导TLR4/NF-κB通路和抑制M1型巨噬细胞极化以缓解放射性口腔黏膜炎”[Phytomedicine第145卷（2025）第X页至第X页/157083]的勘误表
Liqun Jia,Rong Huang,Chen Chen et al.
Liqun Jia et al.
The extracts of Ardisia elliptica fruit attenuate inflammation in LPS-activated BV2 microglia via JNK, ERK1/2, p38, and NF-κB signaling inhibition [0.03%]
Ardisia elliptica果实提取物通过抑制JNK、ERK1 / 2、p38和NF-κB信号通路缓解LPS活化的小胶质BV2细胞的炎症反应
Dusadee Ospondpant,Meixia Yang,Jin Gao et al.
Dusadee Ospondpant et al.
Background: Neuroinflammation is a pivotal defense mechanism against brain infections and injury; the dysregulation contributes to neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease, and mul...
2',4'-dihydroxychalcone induces ferroptosis through ERO1A/GPX4 regulatory axis in cholangiocarcinoma [0.03%]
2',4'-二羟基查耳酮通过ERO1A/GPX4调控轴诱导胆管癌铁死亡
Tong Wang,Xuebing Zhou,Nanmiao Wang et al.
Tong Wang et al.
Background: Cholangiocarcinoma (CCA) , an aggressive cancer often detected late, carries a grim prognosis. 2',4'-Dihydroxychalcone (2',4'-DHC), a flavonoid monomer isolated from Empetrum nigrum, has demonstrated notable a...