Coptisine activates aryl hydrocarbon receptor to regulate colonic epithelial homeostasis in DSS induced ulcerative colitis and TNF-α challenged intestinal organoids [0.03%]
黄连素通过激活芳香烃受体调节DSS诱导的溃疡性结肠炎和TNF-α刺激类器官中结肠上皮稳态
Bingyan Tan,Jingyan Zhang,An Kang et al.
Bingyan Tan et al.
Background: Coptisine is a bioactive isoquinoline alkaloid derived from Coptis Chinensis, exhibiting significant pharmacological potential. Emerging evidence suggests its therapeutic efficacy in gastrointestinal disorders...
Potential application of quercetin as an anti-diabetic treatment: From molecular mechanism to delivery system design [0.03%]
檞皮素作为糖尿病治疗药物的潜在应用：从分子机制到递送系统设计
Fang Liu,Binbin Zhao,Qi Wang et al.
Fang Liu et al.
Background: Quercetin, a natural flavonoid, has demonstrated protective effects against diabetes. Nevertheless, its poor aqueous solubility and chemical instability significantly hinder its clinical application. Nanoencap...
Bupi Yishen formula improves chronic kidney disease by restoring renal energy metabolism and mitochondrial oxidative phosphorylation [0.03%]
补脾益肾方通过恢复肾脏能量代谢和线粒体氧化磷酸化改善慢性肾脏病
Bingran Liu,Guowei Chen,Haoyu Mo et al.
Bingran Liu et al.
Background: Bupi Yishen formula (BYF) is a traditional Chinese herbal mixture with proven efficacy in attenuating kidney function deterioration among patients with advanced chronic kidney disease (CKD), and improving rena...
Core-multiplex-micro component profiling for precision discrimination of multi-sources and adulterated arnebiae radix, from herbs to formulations [0.03%]
从单味药到复方中精准鉴别重楼属药材基原种的核-多层-微粒特征指纹谱成分图Profiler研究
Fei Sha,Jianqing Zhang,Cuicui Wang et al.
Fei Sha et al.
Background: The "one-to-multiple" phenomenon and counterfeiting are prevalent in herbal medicines. Accurately identifying these issues in both crude herbs and commercial formulated products is crucial for ensuring drug sa...
Calycosin alleviates myocardial fibrosis after myocardial infarction by restoring fatty acid metabolism homeostasis through inhibiting FAP [0.03%]
川culusin通过抑制FAP恢复脂肪酸代谢稳态从而缓解心肌梗死后的心肌纤维化作用机制研究
Shu-Ning Sun,Xin Liu,Xing-Ling Chen et al.
Shu-Ning Sun et al.
Background: Myocardial fibrosis is a pivotal pathological mechanism underlying heart failure (HF) following myocardial infarction (MI). Natural herbal compounds exhibit great potential for anti-fibrotic applications, ther...
Enhancing Sirt1-mediated deacetylation of p62 with a self-assembling nanopeptide and resveratrol hydrogel to mitigate sepsis-induced inflammation [0.03%]
利用自组装纳米肽和白藜芦醇水凝胶增强Sirt1介导的p62去乙酰化以缓解脓毒症诱导的炎症反应
Baoquan Wang,Ying Wang,Zhansheng Hu et al.
Baoquan Wang et al.
Background: Sepsis-induced inflammatory damage remains a significant clinical challenge with limited effective treatments. Elucidating the molecular mechanisms that regulate macrophage function may reveal key therapeutic ...
β-Eudesmol in Rhizoma Atractylodis targets AVPR2 to inhibit the cAMP-AQP2 pathway and promote fluid metabolism [0.03%]
白术中的β-欧芹酚通过靶向AVPR2抑制cAMP-AQP2途径以促进机体水平衡功能
Chang Ke,Lijiao Zhong,Ding Yao et al.
Chang Ke et al.
Background: Rhizoma Atractylodis, a classic dryness traditional Chinese medicine (TCM), demonstrates potent fluid metabolism-promoting properties. Previous studies have identified volatile oils as the primary active fract...
Wendan Decoction exerts therapeutic effects on insomnia by regulating gut microbiota and tryptophan metabolism [0.03%]
温胆汤通过调节肠道菌群及色氨酸代谢治疗失眠症
Yuan Tian,Jianguo Meng,Dezhu Zhang et al.
Yuan Tian et al.
Background: Insomnia has been a public problem threatening human health. Wendan Decoction (WDD) has good therapeutic effects on insomnia. However, its mechanism to improve sleep remains unclear. ...
Huangqi Guizhi Wuwu decoction alleviate Oxaliplatin-Induced Peripheral Neuropathy by adjusting the myelin regeneration [0.03%]
黄芪桂枝五物汤通过调节髓鞘的再生治疗奥沙利铂外周神经病变
Xueying Yang,Huaying Zhu,Zhiyu Li et al.
Xueying Yang et al.
Objective: This study aimed to investigate the effect and underlying mechanism of Huangqi Guizhi Wuwu decoction (HQGZWWD) in preventing Oxaliplatin-induced peripheral neurotoxicity (OIPN) in rat models. ...
Nrf2-activated mitophagy and ferroptosis suppression synergistically mediate tangeretin's protection against hepatic ischemia-reperfusion injury [0.03%]
柑橘素通过激活 NRF2 介导的线粒体自噬和抑制铁死亡协同保护肝脏异位再灌注损伤
Deng Liu,Ruixin Zhang,Lixia Zha et al.
Deng Liu et al.
Background: Liver ischemia-reperfusion (I/R) injury frequently arises during liver surgery and significantly contributes to postoperative liver failure and graft dysfunction. Tangeretin (TAN), a polymethoxy flavone presen...