Phillyrin ameliorates sepsis via targeting microRNA-203a-mediated caspase-4/caspase-11/caspase-B downregulation to suppress endothelial pyroptosis [0.03%]
Phillyrin通过靶向microRNA-203a介导的caspase-4/caspase-11/caspase-B下调来抑制内皮细胞焦亡从而改善脓毒症
Xiangjun Zhou,Guangli Yang,Weifu Tan et al.
Xiangjun Zhou et al.
Background: Sepsis, driven by dysregulated host inflammation, remains a leading cause of global mortality and lacks sufficiently effective therapies. Phillyrin (PHN), a lignan glycoside from Forsythia suspensa (Thunb.) Va...
Liuwei Dihuang pills suppress hepatocellular carcinoma via PI3K/AKT/TP53 pathway: Integrating network pharmacology, metabolomics, and experimental validation [0.03%]
六味地黄丸通过PI3K / AKT / TP53信号通路抑制肝癌：网络药理学，代谢组学和实验验证相结合的研究
Hongxin Cai,Qi Hu,Zhiying Song et al.
Hongxin Cai et al.
Hepatocellular carcinoma (HCC) remains a significant global health challenge with limited treatment options. Liuwei Dihuang Pills (LWPs), a classic Traditional Chinese Medicine formula, have demonstrated potential anti-tumor effects; howeve...
The liver kinase B1 mediates the therapeutic efficacy of nuciferine against hepatic lipid accumulation in diabetic KKAy mice [0.03%]
黄酮类化合物芸苔素通过激活LKB1改善糖尿病肝脂肪变性
Yan Guo,Huijian Chen,Tongqing Li et al.
Yan Guo et al.
Background: Type-2 diabetes mellitus (T2DM) is a metabolic disorder characterized by insulin resistance (IR) and β-cell dysfunction. Nuciferine (NCF), derived from plants such as Nelumbo nucifera Gaertn., is an alkaloid ...
The combination of Anoectochilus roxburghii and Danggui-Niantong decoction ameliorates hyperuricemia by regulating NAD+ metabolism and urate transport in rats [0.03%]
岩泉草和当归拈痛汤联合通过调节NAD+代谢及尿酸转运改善高尿酸血症小鼠模型体内尿酸水平的研究
Dong Li,Zhu Tao,Hang Xu et al.
Dong Li et al.
Background: Hyperuricemia (HUA) involves multi-organ dysfunction, particularly hepatic and renal abnormalities. Danggui-Niantong decoction (DGN) is a traditional formula for gout and chronic kidney disease. Clinically, DG...
Berberine promotes β-catenin ubiquitination and inhibits its nuclear translocation by targeting USP22 in colorectal cancers [0.03%]
小檗碱通过靶向USP22促进β-连环蛋白泛素化并抑制其核转位以治疗结直肠癌
Gang Xu,Qihong Yang,Shaohua Zhang et al.
Gang Xu et al.
Wnt/β-catenin signaling pathway is the most frequently altered cascade in colorectal cancer (CRC), and the nucleus accumulation of β-catenin is the hallmark of the activation of Wnt/β-catenin signaling. However, despite extensive researc...
Panax notoginseng saponins ameliorate spinal cord injury by inhibiting JAK2/STAT3-mediated macrophage polarization: Enhanced delivery by ultrasound-targeted microbubble destruction [0.03%]
三七总皂苷通过抑制JAK2/STAT3介导的巨噬细胞极化改善脊髓损伤：声靶向微泡破坏增强递送
Yin Shi,Xuelian Chen,Shu Luo et al.
Yin Shi et al.
Background: Spinal cord injury (SCI) causes abnormal macrophage polarization, worsening inflammation and neuronal apoptosis, with current therapies showing limited efficacy. Panax Notoginseng Saponins (PNS) has anti-infla...
Phytochemical characterization and multi-target protective effects of Lycopodium serratum var. longipetiolatum against dysmenorrhea [0.03%]
Lycopodium serratum var. longipetiolatum的植化素分析及其抗痛经多靶标保护作用研究
Yi-Fen Chiang,Cheng-Pei Chung,Ko-Chieh Huang et al.
Yi-Fen Chiang et al.
Background: Primary dysmenorrhea is associated with aberrant uterine contractility, inflammatory activation, and oxidative stress, resulting in nociceptive hypersensitivity and impaired quality of life. Lycopodium serratu...
Baohuoside I induces GSDME-dependent pyroptosis and synergistically inhibits lung adenocarcinoma with cisplatin [0.03%]
宝藿苷I通过诱导依赖于GSDME的焦亡与顺铂协同抑制肺腺癌
Ying Yang,Luchanghao Zheng,Tao Zhao et al.
Ying Yang et al.
Background: Pyroptosis is a form of inflammatory programmed cell death and has been proven to be a promising therapeutic strategy for cancer. To date, little is known about the natural product inducers of pyroptosis. Baoh...
Hemoglobin adduction and impaired oxygen transport define the etiology of pyrrolizidine alkaloid-induced pulmonary arterial hypertension [0.03%]
血红蛋白交联和氧气运输障碍界定了吡咯里西啶生物碱引起的肺动脉高压的病因
Caibin Zhang,Tianyang Huang,Xiaokai Guo et al.
Caibin Zhang et al.
Background: Pyrrolizidine alkaloids (PAs), particularly monocrotaline (MCT), are common phytotoxins known to induce pulmonary arterial hypertension (PAH), a progressive and fatal cardiopulmonary disease. However, the spec...
Ailanthone hijacks ERK/NF-κB cascade to attenuate osteoclastogenesis for osteoporosis [0.03%]
艾叶醇通过干扰ERK/NF-κB信号通路来抑制破骨细胞的生成从而治疗骨质疏松症
Xiaodi Zhang,Jianning Kang,Qianyun Wang et al.
Xiaodi Zhang et al.
Background: Osteoporosis is a serious bone disease, it can eventually lead to disability. However, no safe or effective intervention is currently available. Therefore, there is an urgent need to develop effective drugs th...