Pelargonium sidoides - from ethnopharmacology to evidence-based medicine: a systematic review [0.03%]
Pelargonium sidoides：从民族药理学至实证医学——系统综述研究
Oksana Honchar,Olha Мykhailenko,Olha Holovchenko et al.
Oksana Honchar et al.
Background: Pelargonium sidoides DC. (Geraniaceae) has a long history of traditional use among indigenous peoples of Southern Africa for treating respiratory and gastrointestinal disorders. Its transformation into the mod...
Genistein ameliorates lupus nephritis via enhancing ERβ-mediated inhibition of STAT3-driven inflammation [0.03%]
染料木素通过增强雌激素受体β介导的STAT3驱动炎症抑制作用来改善狼疮性肾炎
Jieli Pan,Jinjun Ji,Xingpan Xin et al.
Jieli Pan et al.
Background: Systemic lupus erythematosus (SLE) is an autoimmune disease with marked female predominance. Lupus nephritis (LN), one of its most severe manifestations, is strongly associated with aberrant activation of sign...
Baitouweng decoction regulates ferroptosis-mediated mitophagy and apoptosis through the SLC7A11/GPX4/FTH1 pathway in ulcerative colitis [0.03%]
白头翁汤通过SLC7A11/GPX4/FTH1信号通路调节溃疡性结肠炎铁死亡介导的线粒体自噬和细胞凋亡
Liuliang Zhang,Xiaolan Zhu,Xiaochao Hu et al.
Liuliang Zhang et al.
Background: The prevalence of ulcerative colitis (UC) has increased recently, with severe cases potentially progressing to colon cancer. The classic herbal formula Baitouweng Decoction (BTW) has a centuries-long clinical ...
Anti-tumor effects of Guggulsterone in osteosarcoma: Role of SIRT3-mediated PINK1-Parkin mitophagy activation [0.03%]
吴茱萸素通过SIRT3介导的PINK1-Parkin线粒体自噬激活发挥抗骨肉瘤作用
Lingyuan Zeng,Shuwei Li,Kaidong Wu et al.
Lingyuan Zeng et al.
Osteosarcoma (OS) is an aggressive primary bone malignancy characterized by limited therapeutic options and poor prognosis in advanced stages. Guggulsterone (GS), a naturally occurring plant-derived sterol, has recently been reported to sup...
Vitex negundo Linn.: A decade of advances in phytochemistry, pharmacological activities, and biotechnological interventions (2015-2025) - A comprehensive review [0.03%]
Vitex negundo Linn：2015-2025年植物化学、药理活性和生物技术干预的十年进展——全面综述
Pratik Vinayak Phate,Anita Surendra Patil
Pratik Vinayak Phate
Relevance: Vitex negundo Linn. is an important medicinal plant widely used in traditional medicine, particularly for inflammatory and pain-related conditions. Recent advances in phytochemical characterization, mechanistic...
Ethyl ferulate suppresses choroidal neovascularization by accelerating Keap1 degradation through the inhibition of PSMD14-mediated deubiquitination [0.03%]
乙基阿魏酸通过抑制PSMD14介导的去泛素化促进Keap1降解从而抑制脉络膜新生血管生成
Rong Xue,Yi-Chen Dong,Xia Wang et al.
Rong Xue et al.
Background: Choroidal neovascularization (CNV) is a leading cause of central vision impairment with limited treatment options. Ethyl ferulate is a natural compound with antioxidant and anti-angiogenic properties; however,...
Ginsenosides remodel tumor immune microenvironment through metabolic reprogramming: Targets and mechanisms [0.03%]
人参皂苷通过代谢重编程重塑肿瘤免疫微环境：靶点与机制研究
Zhong-Wei Yao,Yong-Qing Wang,He Zhu
Zhong-Wei Yao
Background: Metabolic reprogramming is a hallmark of cancer development. By regulating energy and nutrient metabolism, it shapes an immunosuppressive tumor microenvironment (TME) that supports rapid tumor proliferation an...
Zhi-Chuan-Ling alleviates OVA-induced allergic asthma by suppressing M2 macrophage polarization via the PI3K/AKT/mTOR/STAT6 pathway [0.03%]
柴胡灵通过抑制PI3K/AKT/mTOR/STAT6信号通路介导的M2型巨噬细胞极化缓解卵清蛋白致敏的小鼠哮喘模型的症状
Sihui Xing,Huidan Chen,Ling Wang et al.
Sihui Xing et al.
Background: Allergic asthma, predominantly driven by Th2 immune responses, is a chronic respiratory disease that poses a significant threat to human health. Zhi-Chuan-Ling (ZCL), a traditional Chinese medicine widely used...
Dieckol, a phlorotannin from Ecklonia cava, alleviates stress hormone-induced depressive-like behaviors through glucocorticoid receptor antagonism [0.03%]
石松属海藻有效成分dieckol通过糖皮质激素受体拮抗作用缓解应激激素诱导的抑郁样行为
Inhye Park,Jung-Eun Lee,Minji Kim et al.
Inhye Park et al.
Background: Depression imposes significant social, economic, and health burdens worldwide. Although phlorotannin-rich extract from Ecklonia cava (PS) and its active compound dieckol (DK) exhibit various biological activit...
Xiao-Yao-San suppresses psychological distress-related colorectal cancer metastasis and enhances antitumor immune responses through regulating gut microbiota-bile acid axis [0.03%]
逍遥散通过调节肠道菌群-胆汁酸轴抑制心理压力相关的结直肠癌转移并增强抗肿瘤免疫反应
Xinxin Hou,Xiangxiang Zhu,Yuanyuan Feng et al.
Xinxin Hou et al.
Background: Psychiatric disorders are recognized as risk factors for tumor progression and metastasis in colorectal cancer (CRC). Xiao-Yao-San (XYS), a traditional Chinese herbal formula with antidepressant properties, ha...