Integrated transcriptome and metabolome analysis reveals the therapeutic mechanism of Huang-Qi-Si-Wu-Tang in experimental pulmonary arterial hypertension [0.03%]
黄芪四物汤治疗实验性肺动脉高压的整合转录组和代谢组分析研究机制
Ye Wang,Zhuangjie Guo,Xinqi Ma et al.
Ye Wang et al.
Background: Pulmonary arterial hypertension is a complex vascular disease involving pathological remodeling of vascular cells, inflammatory cells, and the extracellular matrix. Current PAH therapies, which are primarily v...
Matrine targets β-catenin and blocks the formation of β-catenin/TCF7L2 complex to promote ferroptosis and inhibit metastasis in triple-negative breast cancer [0.03%]
小檗碱通过靶向β-连环蛋白和阻断β-连环蛋白/TCF7L2复合物的形成促进铁死亡并抑制三阴性乳腺癌转移
Yazhou Sang,Yue Hu,Ruohan Liang et al.
Yazhou Sang et al.
Background: Triple-negative breast cancer (TNBC) is still incurable, exhibiting a high propensity for metastasis. Matrine has been confirmed to possess anti-tumor properties. Nevertheless, the precise mechanism by which m...
An integrative analysis reveals mechanisms of Prunella vulgaris in thyroid cancer metastasis [0.03%]
整合分析揭示了石斛属紫花地丁（直序草属）在甲状腺癌转移中的机制
Shifan Zeng,Benjuan Liu,Rui Ge et al.
Shifan Zeng et al.
Background: Lymph node metastasis (LNM) in papillary thyroid carcinoma (PTC) is a major contributor to poor prognosis. Prunella vulgaris (P. vulgaris), a traditional medicinal herb, has shown potential in inhibiting PTC m...
Lycopene ameliorates Di-(2-ethylhexyl) phthalate-induced neurotoxicity in mice via the gut-brain axis [0.03%]
番茄红素通过肠-脑轴缓解Di-(2-乙基己基)邻苯二甲酸对小鼠的神经毒性作用
Li-Jian Chen,Yi Liu,Jia-Li Liu et al.
Li-Jian Chen et al.
Background: Di(2-ethylhexyl) phthalate (DEHP), a ubiquitous plasticizer present in numerous consumer products, poses a substantial neurotoxic risk through environmental and dietary exposure. Growing evidence highlights a ...
Integrated chemical composition, transcriptomics, and network pharmacology to reveal the mechanism of Jia-Wei-Si-Miao-Yong-An Decoction in ACS model rats [0.03%]
基于ACS模型大鼠的化学成分、转录组和网络药理整合研究加味四妙勇安汤治疗糖尿病足的作用机制
Ning Zhao,Mengya Dang,Yangyang Sun et al.
Ning Zhao et al.
Background: Acute Coronary Syndrome (ACS), as the most critical pathological type of coronary atherosclerotic heart disease, has a high morbidity and lethality, and the long-term treatment of modern medicine is still face...
Anxiolytic effects of corilagin by targeting Htr2c through activation of the TrkB/CREB/BDNF pathway [0.03%]
大黄素通过激活TrkB/CREB/BDNF通路靶向Htr2c产生抗焦虑作用
Xiaoyun Yun,Jianhui Wu,Jie Zhou et al.
Xiaoyun Yun et al.
Background: Anxiety disorders rank among the most ubiquitous neuropsychiatric disease classifications. Despite their substantial disease burden, the persistent lack of innovative, mechanistically grounded therapeutic inte...
Cistanoside F acts as a Monoacylglycerol Lipase inhibitor that synergizes the anti-tumor effect of 2-Arachidonoyl Glycerol on Bladder cancer [0.03%]
白花丹素F通过协同促进2-花生四烯酸甘油的抗肿瘤作用抑制单酰基甘油酶
Yu-Jun Tan,Yu-Shan Ren,Jun-Lin Lv et al.
Yu-Jun Tan et al.
Background: Bladder cancer (BCa) remains clinically challenging due to high recurrence rates. As an endocannabinoid, 2-arachidonoylglycerol (2-AG) plays a pivotal role in regulating numerous physiological and pathological...
Loganin epigenetically rescues mitochondrial complex III dysfunction via DNMT1-UQCRC1 demethylation to halt cardiac remodeling after myocardial infarction [0.03%]
loggentin通过DNMT1-UQCRC1去甲基化从机制上表观遗传学地解救线粒体复合物III功能障碍以在心肌梗死后阻止心脏重塑
Yunjing Wang,Renshan Chen,Huaqian Dou et al.
Yunjing Wang et al.
Background and purpose: Loganin, an iridoid glycoside from Cornus officinalis, exhibits cardioprotective potential. While previous studies focused on its antioxidant and anti-inflammatory properties, its role in myocardia...
Breviscapine injection and its main component scutellarin prevents lethal enterovirus infection by inhibiting neuroinflammation and oxidative stress in newborn mice [0.03%]
灯台叶注射液及其主要成分天仙子胺通过抑制新生小鼠神经炎症和氧化应激来预防致命的肠道病毒感染
Wenhui Yang,Junyi Wang,Yi Tao et al.
Wenhui Yang et al.
Background: Enterovirus 71 (EV71) is the primary cause of severe neurological infections associated with Hand, Foot and Mouth Disease (HFMD) in children, and no specific therapeutic agent is available. Breviscapine inject...
Butyrate-producing commensal bacteria mediates the efficacy of herbal medicine JCM-16021 on abdominal pain in diarrhea-predominant irritable bowel syndrome: a randomized clinical trial [0.03%]
产生丁酸的共生细菌介导了中药JCM-16021对腹泻型肠易激综合征腹痛疗效的作用：一项随机临床试验
Lixiang Zhai,Ya Zheng,Cho Wing Lo et al.
Lixiang Zhai et al.
Background: Irritable bowel syndrome with diarrhea (IBS-D) presents significant treatment challenges due to limited therapeutic options that effectively target the underlying pathophysiological mechanisms. In this study, ...