Trichodermin, an endophytic fungal sesquiterpene, suppresses colorectal cancer cell migration and invasion by targeting the PKC-ERK-Sp1-CTSV axis [0.03%]
鬼笔环肽同源天然内生真菌 Sesquiterpene 通过靶向 PKC-ERK-Sp1-CTSV 轴抑制结直肠癌细胞迁移和侵袭
Cheng-Ta Lai,Yi-Hsien Hsieh,Yi-Hsin Wang et al.
Cheng-Ta Lai et al.
Background: Trichodermin (TCD), a sesquiterpene initially isolated from the fungus Trichoderma viride, has previously shown potent activity against pancreatic tumors and chondrosarcoma. However, its therapeutic potential ...
The antitumor effects of lupenone on colon cancer and its mechanistic insights [0.03%]
狼毒素的抗肿瘤作用及机制研究 colon cancer翻译为“结肠癌”更为准确，但“大肠癌”也是一种常见的译法，这里根据习惯翻译成“大肠癌”。因此，中文标题可以是：“狼毒素的大肠癌抗肿瘤效果及其机理研究”
Ruli Li,Rongrong Wang,Xuemei Wang et al.
Ruli Li et al.
Background: Lupenone, a natural constituent derived from medicinal plants and fruits, is classified as a lupane-type triterpenoid and is known for its diverse biological activities, including anti-diabetic, anti-cancer, a...
Total saponins from Panax japonicus inhibit phosphatidylcholine hydrolysis and relieve hepatic steatosis via the miR-1a-3p/PLD1 pathway [0.03%]
日本人参总皂苷通过miR-1a-3p/PLD1信号通路抑制磷脂酰胆碱水解缓解肝脏脂质沉积
Ning Yang,Jingjie Yang,Yulan Shi et al.
Ning Yang et al.
Background: Panax japonicus (T. Nees) C.A. Mey., a member of the Araliaceae family, has been utilized for medicinal purposes by the Tujia and Hmong ethnic groups in China for over a thousand years. In traditional Chinese ...
Blueberry anthocyanins ameliorate arsenic-induced cognitive impairment in rats: mitigating mitochondrial damage and dysregulation [0.03%]
蓝莓花青素通过减轻线粒体损伤和失调缓解大鼠砷致认知障碍
Xinbo Ma,Yang Liu,Bo Ding et al.
Xinbo Ma et al.
Background: Blueberry anthocyanin extract (BAE) is a natural antioxidant flavonoid found in blueberries that has the potential to alleviate oxidative stress-induced neurodegeneration. Previous studies have demonstrated th...
Mai Guan Fu Kang tablet (MGFK) accelerates diabetic foot ulcer healing via antioxidant defense and inflammation suppression [0.03%]
mai guan fu kang胶囊通过抗氧化防御和抑炎促进糖尿病足溃疡愈合
Xiaowen Jiang,Ziyang Han,Yue Jin et al.
Xiaowen Jiang et al.
Background: Diabetic foot ulcer (DFU), a severe complication of diabetes characterized by impaired healing and high morbidity, demand novel therapeutic strategies. Mai Guan Fu Kang tablets (MGFK) and combined therapy have...
Fucoidan alleviates renal fibrosis in mice via Akkermansia muciniphila-mediated suppression of NEU1-TLR4-NFκB signaling axis [0.03%]
岩藻糖甘露聚糖通过Akkermansia muciniphila介导的NEU1-TLR4-NF-кB信号轴抑制缓解肾纤维化
Zhen Wang,Xiao-Ling Rong,Cai-Xia Dai et al.
Zhen Wang et al.
Background: Fucoidan, a bioactive sulfated polysaccharide, is renowned for its extensive range of biological activities, including anticancer activity, antioxidative properties, immune activation and has demonstrated supp...
Oroxyloside inhibits liver fibrosis and hepatocarcinogenesis dependent on hepatocyte-specific knockout of Atg5 [0.03%]
Oroxyloside通过特异性敲除肝细胞Atg5抑制肝纤维化和肝癌发生
Yunyao Liu,Liu Chen,Xingyu Liu et al.
Yunyao Liu et al.
Background & aims: Hepatocellular carcinoma (HCC), a leading cause of cancer-related mortality, is closely linked to liver fibrosis, yet effective preventive therapies remain elusive. Autophagy is a critical cellular proc...
Celastrol protected the MPTP-injected mice Parkinson's disease model via redox regulation of CDC37 [0.03%]
通过CDC37的氧化还原调节 celastrol 保护 MPTP 注射小鼠帕金森病模型
Wanfen Liao,Aiwen Dong,Fatima Hafeez et al.
Wanfen Liao et al.
Background: Celastrol (CEL), a bioactive compound isolated from Tripterygium Wilfordii Hook. F, exerts neuroprotective effects through anti-oxidative, anti-inflammatory, and anti-apoptotic mechanisms in several neurodegen...
Plant-based strategies against aging: Focus on bioactive compounds from medicine-food homology plants [0.03%]
基于药食同源植物活性成分的抗衰老策略研究进展
Yun-Fei Zhu,An-Guo Wu,Meng-Yi Chen et al.
Yun-Fei Zhu et al.
Background: As a biologically intricate process, aging entails functional impairment and predisposes individuals to chronic conditions. Medicine-food homology (MFH) plants, deeply rooted in traditional Chinese medicine, a...
Maiwei Yangfei decoction protects against pulmonary fibrosis by suppressing NLRP3 inflammasome-mediated pyroptosis of alveolar macrophage [0.03%]
Maiwei Yangfei汤通过抑制肺泡巨噬细胞NLRP3炎症小体介导的焦亡保护肺纤维化
Dongwei Zhu,Qi Zhao,Tingyu Pan et al.
Dongwei Zhu et al.
Background: Pulmonary fibrosis (PF) is a progressive and irreversible pathological manifestation of fibrotic interstitial lung diseases, characterized by chronic inflammation, excessive extracellular matrix (ECM) depositi...