Linggui Zhugan Decoction mitigates post-myocardial infarction heart failure through modulation of cardiomyocyte F-actin cytoskeletal organization [0.03%]
苓桂术甘汤通过调节心肌细胞F肌动蛋白骨架组织改善心梗后心力衰竭
Maojun Cheng,Liyang Li,Xing Huang et al.
Maojun Cheng et al.
Background: Linggui Zhugan Decoction (LGZGD), a traditional Chinese formula for spleen-strengthening and yang-warming to resolve fluid retention, has consistently shown efficacy in preventing and treating heart failure. H...
YTHDF2-orchestrated m6A methylation of BECN1 induces Scoparone-mediated hepatic stellate cell ferroptosis to attenuate liver fibrosis [0.03%]
YTHDF2介导的BECN1m6A甲基化诱导Scoparone介导的肝星状细胞铁死亡以减缓肝纤维化
Yuqi Sun,Yanshuang Zhuang,Kaiwen Cheng et al.
Yuqi Sun et al.
Background: Liver fibrosis represents a dynamically reversible pathological process arising as an adaptive repair response to chronic hepatic insults. Scoparone (SCO), an active constituent of artemisia, has demonstrated ...
Isodeoxyelephantopin mitigates DSS-induced ulcerative colitis by suppressing IL-1β-driven inflammation via the TXNIP/NLRP3 axis [0.03%]
异去氧 Elephantopin 通过抑制 TXNIP/NLRP3 轴上驱动的 IL-1β 炎症缓解 DSS 诱导的溃疡性结肠炎
Li-Yuan Lin,Heng-Zhen Li,Xiang-Qian Liu et al.
Li-Yuan Lin et al.
Background: Isodeoxyelephantopin (IDET) is a sesquiterpene lactone isolated from traditional herb Elephantopus scaber, which is known for its anti-inflammatory activities. While our previous study demonstrated that IDET i...
Novel strategies for identification and prevention of idiosyncratic liver injury caused by TCM compatibility: Exemplification by Epimedii Folium and Psoraleae Fructus [0.03%]
基于淫羊藿与补骨脂配伍致肝损伤的筛选与防治新策略研究
Wei Shi,Hui Li,Tingting Liu et al.
Wei Shi et al.
Background: Traditional Chinese medicine (TCM) compatibility (TCMC) is an important form of clinical application of TCM, and proper compatibility are key to ensuring the safe use of TCM. However, reports of liver injury a...
Berberine reverses impaired adipose angiogenesis to promote beige adipogenesis by HIF-1α/PRDM16 signaling [0.03%]
小檗碱通过HIF-1α/PRDM16信号诱导脂肪血管生成从而促进 beige脂肪生成
Chien-Shan Cheng,Jingxian Chen,Yuan Wu et al.
Chien-Shan Cheng et al.
Background: Obesity-induced adipose tissue expansion is characterized by capillary rarefaction and hypoxia, which disrupts angiogenesis and impairs beige adipogenesis. While angiogenesis is known to be crucial for beiging...
Pharmacological targeting of NR4A1 restrains lipid metabolism-ferroptosis axis in UVR-induced skin aging [0.03%]
药理靶向NR4A1限制UVR诱导的皮肤老化中的脂质代谢-铁死亡轴
Hongjin Wang,Jingjing Li,Xiaogang Xu et al.
Hongjin Wang et al.
Background: Skin photo-aging induced by ultraviolet radiation (UVR) leads to aesthetic alterations, structural degradation, and loss of barrier function. Ferroptosis has been implicated upon UVR stress but the driving mod...
Spatial-single cell multiomics reveals TRIM44-driven Treg differentiation and drug resistance in AML: Therapeutic reversal by Sinomenine [0.03%]
空间单细胞多组学揭示TRIM44驱动的AML中Treg分化和药物耐药：异蛇根草素逆转治疗
Zhixuan Deng,Woding Deng,Ning Tang et al.
Zhixuan Deng et al.
Background: Acute myeloid leukemia (AML) is a heterogeneous hematological malignancy characterized by genetic diversity. These features of AML contribute to immune evasion and therapeutic resistance. Relapse after chemoth...
Andrographolide ameliorates vascular injury in hypertension by suppressing EndMT via Sp1-Notch1 signaling [0.03%]
andrographolide通过抑制Sp1-Notch1信号通路介导的内皮-间充质转化改善高血压血管损伤
Qiang Tu,Wenling Li,Yanxia Qiu et al.
Qiang Tu et al.
Background: Endothelial-to-mesenchymal transition (EndMT) is a potential therapeutic target for hypertension-induced vascular injury. Andrographolide (AGP) is a bioactive labdane diterpenoid that confers cardiovascular pr...
Quercetagitrin targets EIF3D to activate NCOA4-mediated ferritinophagy-dependent ferroptosis for the treatment of non-small cell lung cancer [0.03%]
檞皮素茋酮通过靶向EIF3D激活NCOA4介导的铁死亡依赖性铁蛋白自噬对非小细胞肺癌进行治疗
Xinglinzi Tang,Feiyan Wu,Huijuan Rao et al.
Xinglinzi Tang et al.
Background: Non-small cell lung cancer (NSCLC) is the predominant subtype of lung cancer. Although traditional treatment methods such as surgery, chemotherapy, and radiotherapy can extend patient survival to some extent, ...
Dehydrocavidine alleviates lipopolysaccharide-induced acute liver injury by activating Nrf2 signaling pathway to inhibit hepatocyte ferroptosis [0.03%]
去氢卡瓦丁通过激活Nrf2信号通路抑制肝细胞铁死亡从而改善脂多糖诱导的急性肝损伤
Hongbiao Liang,Guizimeng Hu,Dongmin Yang et al.
Hongbiao Liang et al.
Background: Sepsis-induced acute liver injury (SALI) remains a major challenge with limited effective treatments. Although Corydalis saxicola Bunting (CSB) exhibits anti-inflammatory and hepatoprotective properties, its r...