Brusatol ameliorates irinotecan-induced delayed diarrhea via inhibition of the cGAS-STING pathway and modulation of intestinal flora [0.03%]
溴司亭通过抑制cGAS-STING通路和调节肠道菌群缓解伊立替康所致迟发性腹泻
Zixuan Lai,Yong Zhang,Weimu Huang et al.
Zixuan Lai et al.
Background: Irinotecan, a widely used chemotherapeutic agent, has seen its clinical application constrained by delayed diarrhea. Brucea javanica, with documented historical use in dysentery management, demonstrates antica...
Neuroprotective effects of Rosavin via HIF-1α signaling in a rat model of ischemic stroke [0.03%]
通过HIF-1α信号传导研究石杉素甲在缺血性卒中大鼠模型中的神经保护作用
Wenfang Lai,Jingwen Nie,Anqi Hong et al.
Wenfang Lai et al.
Background: Ischemic stroke is a common cerebrovascular disease and a major global cause of permanent disability and death. Angiogenesis plays a critical role in neurological recovery during cerebral ischemia. Rosavin is ...
Achyranthes Bidentata Radix mitigates neuronal apoptosis via regulation of JUN and CREB in the cAMP signaling pathway [0.03%]
益母草根抑制cAMP信号通路中的JUN和CREB蛋白从而缓解神经元凋零作用机制研究
Yan Liu,Ai-Bing Chang,Yan-Ru Liu et al.
Yan Liu et al.
Background: Although Achyranthes Bidentata Radix (ABR) demonstrates neuroprotective potential in NDDs, its anti-apoptotic mechanisms remain unclear. Purpo...
Gasdermins family-mediated cell survival: exploration of natural products intervention mechanisms [0.03%]
气体dermin家族介导的细胞存活：天然产物干预机制的研究
Wenwen Zhang,Jing Yan,Zexin Wang et al.
Wenwen Zhang et al.
Background: Gasdermins (GSDMs) are a family of pore-forming proteins that play central roles in programmed cell death, inflammation, and immunity. While individual GSDM members-particularly GSDMD and GSDME-have been studi...
Cimicifuga foetida and C. racemosa prevent postmenopausal osteoporosis by inhibiting autophagy of osteoclasts via CB2R and ERα [0.03%]
苍术和粗肋草通过CB2R和ERα抑制破骨细胞自噬预防绝经后骨质疏松症
Si-Jing Hu,Zi-Hui Zhao,Gao-Ce Chen et al.
Si-Jing Hu et al.
Background: Cannabinoid receptor type 2 (CB2R) and estrogen receptor alpha (ERα) activators have been shown to possess remarkable regulatory effects on bone metabolism. Cimicifuga foetida l. (CF), the same genus plant as...
Antitumor effects of cannabidiol (CBD) on osteosarcoma by targeting TNF-α/NF-κB/CCL5 signaling axis [0.03%]
大麻二酚抗骨肉瘤作用及对TNF-α/NF-κB/CCL5信号轴的作用
Fan Yang,Shuqin Duan,Jingwei Liu et al.
Fan Yang et al.
Background: Osteosarcoma remains a therapeutic challenge due to its aggressive behavior and high metastatic potential, necessitating exploration of novel treatment modalities. Cannabidiol (CBD), a non-psychoactive phytoca...
Multi-omics analyses reveal that hesperidin ameliorates high-altitude pulmonary hypertension by restoring gut-lung axis homeostasis [0.03%]
多组学分析揭示柚皮素通过恢复肠肺轴稳态改善高原性肺动脉高压
Lei Fang,Tao Yang,Yiliyaer Nijiati et al.
Lei Fang et al.
Background: Currently, conventional therapies for pulmonary hypertension have limited efficacy in treating high-altitude pulmonary hypertension (HAPH). Hesperidin, a bioactive flavonoid known for its multiple pharmacologi...
Magnolin Promotes PINK1-Parkin-mediated Mitophagy in Diffuse Large B-cell Lymphoma Cells via PPAR-γ Pathway [0.03%]
magnolignan通过PPAR-γ通路促进PINK1-Parkin介导的弥漫大B细胞淋巴瘤细胞线粒体自噬
Xiaoli Zhou,Qianqian Guo,Qiqi Qiao et al.
Xiaoli Zhou et al.
Background: Diffuse large B-cell lymphoma (DLBCL) is both genetically and phenotypically heterogeneous, yet precise treatment strategies are insufficient. Magnolin, a natural compound derived from the Magnolia plant, has ...
Jiangtang Tiaozhi formula ameliorates MASLD by regulating liver ABCD2/PEX2/ATGL axis-mediated fatty acid metabolic reprogramming [0.03%]
姜汤调脂方通过调节肝脏ABCD2/PEX2/ATGL轴介导的脂肪酸代谢重编程改善马兜铃酸性肝损伤
Runyu Miao,Yanjiao Zhang,Yuxin Zhang et al.
Runyu Miao et al.
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) prevalence is rising, increasing risks of cirrhosis and hepatocellular carcinoma. The herbal formula Jiangtang Tiaozhi (JTTZF) clinically allevi...
Jing An decoction alleviates neuroinflammation in Tourette syndrome by regulating butyrate-mediated microbiota-gut-brain axis [0.03%]
静安汤通过调节丁酸介导的微生态系统-肠-脑轴来缓解抽动症神经炎症作用机制研究
Xiaoyu Kang,Enhao Cheng,Peixian Guo et al.
Xiaoyu Kang et al.
Background: Jing An decoction (JA), a traditional Chinese medicine formulation, has demonstrated notable clinical efficacy in the treatment of Tourette syndrome (TS) over the past two decades. The gut-brain axis (GBA) cri...