GuBen AnTai decoction ameliorates recurrent spontaneous abortion by suppressing excessive autophagy via EGFR/PI3K pathway modulation [0.03%]
归肾安胎汤通过调节EGFR/PI3K信号通路抑制过度自噬以治疗复发性流产
Mingyue Han,Zhuoxuan Su,Bingyao Yang et al.
Mingyue Han et al.
Background: The Chinese herbal formula Guben Antai Decoction (GBAT) demonstrates efficacy in reducing pregnancy loss associated with recurrent spontaneous abortion (RSA). However, the molecular mechanisms underlying its i...
Multi-omics reveals hepatotoxic mechanisms and key toxic components of Polygoni Multiflori Radix and its processed products [0.03%]
多组学揭示何首乌及其炮制品肝毒机制及关键毒性成分
Qi Wu,Ziyi Chen,Zong Hou et al.
Qi Wu et al.
Background: Polygoni Multiflori Radix (PMR) and its processed form, Polygoni Multiflori Radix Praeparata (PMRP), are two widely used traditional Chinese medicines (TCM). However, in recent years, frequent reports have eme...
Mulberroside A inhibits NLRP6 to prevent alveolar macrophage efferocytosis and lung-derived SAA3-platelet transport in high fructose-induced hippocampal inflammation [0.03%]
桑皮素A通过抑制NLRP6介导的肺泡巨噬细胞 engulfment 及高果糖诱导的小胶质细胞对肺源SAA3-血小板复合物的摄取，减轻海马体炎症反应
Lei-Lei Zhu,Zi-An Miao,Rong-Zhan Zhang et al.
Lei-Lei Zhu et al.
Introduction: High fructose is reported to induce lung and hippocampus inflammatory injury. Mulberroside A, derived from the traditional Chinese herb Cortex mori, which is commonly used to treat coughs and bronchitis, has...
Effects of crocetin, a constituent of saffron, on indomethacin-induced gastric ulcer and related anxiety-like behavior in rats [0.03%]
番红花成分藏红花素对吲哚美辛致大鼠胃溃疡及相关的类似焦虑行为的影响
Sina Tamaddonfard,Amir Abbas Farshid,Esmaeal Tamaddonfard et al.
Sina Tamaddonfard et al.
Background: Crocetin (CRT), one of the active ingredients in saffron, exerts health-promoting effects on body systems such as neuroprotective, cardioprotective and hepatoprotective properties. ...
Validates blood pressure control for seizure management: Jujuboside B exerts antiseizure effects via blood pressure reduction and activation of NTS-VGLUT2+ neurons [0.03%]
通过降血压和激活NTS-VGLUT2+神经元发挥抗惊厥作用的丁香苷B验证了血压控制在癫痫管理中的有效性
Xia Qin,Wenya Zhao,Siruan Chen et al.
Xia Qin et al.
Background: The interaction between the cardiovascular and brain is crucial for epileptogenesis, but the underlying mechanisms are unclear. Ziziphi Spinosae Semen (ZSS), a traditional herb used for its heart-nourishing an...
Tongmai Yishen Formula alleviates post-stroke depression by restoring neuronal homeostasis in the lateral habenula via the ITPKA signaling pathway [0.03%]
通脉益神方通过ITPKA信号途径恢复侧缰核神经元稳态治疗中风后抑郁综合征
Zhen-Ling Liu,Yu Wang,Feng-Xian Hu et al.
Zhen-Ling Liu et al.
Background: Post-stroke depression (PSD) is a common and debilitating complication of stroke, characterized by persistent abnormalities in neuronal excitability and synaptic plasticity. The lateral habenula (LHb) has emer...
Rewiring the regulated cell death network in diabetic retinopathy: natural products as system-level modulators [0.03%]
糖尿病视网膜病变中调节细胞死亡网络的重塑：天然产物作为系统水平调控因素
Qun Huang,Tingru Chen,Fang Wang et al.
Qun Huang et al.
Background: Diabetic retinopathy (DR) pathogenesis is driven by the dysregulation of an interconnected network of regulated cell death (RCD) modalities, including apoptosis, autophagy-dependent cell death, pyroptosis, and...
Renqingchangjue ameliorates MNNG-induced chronic atrophic gastritis by inhibiting the TNF/NF-κB/Caspase-3 axis [0.03%]
雷公藤红苷通过抑制TNF/NF-κB/Caspase-3信号轴改善MNNG致慢性萎缩性胃炎
Yuan Chen,Guang Yue,Yanjun Liu et al.
Yuan Chen et al.
Background: Chronic atrophic gastritis (CAG) is a pivotal premalignant stage in the Correa cascade, characterized by progressive and largely irreversible loss of gastric glands and an elevated risk of gastric cancer. Renq...
Eicosapentaenoic acid attenuates heart failure with preserved ejection fraction via promoting TREM2-dependent efferocytosis [0.03%]
二十碳五烯酸通过促进TREM2依赖性凋亡小体清除来缓解射血分数保留的心力衰竭
Yingying Xie,Haoming He,Yike Li et al.
Yingying Xie et al.
Background: Heart failure with preserved ejection fraction (HFpEF) constitutes over 50% of heart failure cases but lacks disease-modifying therapies. The pathophysiological role of eicosapentaenoic acid (EPA) in HFpEF rem...
Combining network pharmacology and multi-omics reveals the role of Shengdihuang-Huangqi herb pair in alleviating type 2 diabetes mellitus [0.03%]
网络药理学和多组学揭示生地黄与黄芪药对缓解2型糖尿病的作用机制
Xianglin Cao,Yuhan Shang,Mengyao Qu et al.
Xianglin Cao et al.
Objective: This study aimed to elucidate the therapeutic mechanisms of the Shengdihuang-Huangqi (SDHHQ) herbal pair in type 2 diabetes mellitus (T2DM) by integrating network pharmacology, transcriptomics, and metabolomics...