Elimination of gut microbiota hinders the therapeutic effect of amentoflavone on respiratory syncytial virus-induced lung inflammation injury by regulating innate immunity [0.03%]
肠道微生物群的消除通过调节先天免疫反应影响amentoflavone对呼吸道合胞病毒诱导的肺炎性损伤治疗作用的研究
Ya-Lei Sun,Yu Guo,Xin- Yu Wang et al.
Ya-Lei Sun et al.
Background: Respiratory syncytial virus (RSV) is a major cause of bronchiolitis and pneumonia in infants and the elderly. Currently, there are no approved RSV-specific therapeutic small molecules available. Amentoflavone ...
Xinyue capsule treatment on long-term outcomes in patients with stable coronary artery disease after PCI: A 10-year observational follow-up [0.03%]
欣越颗粒对PCI术后稳定型冠心病患者长期预后的影响：10年随访观察研究
Ming Guo,Pengfei Chen,Jianpeng Du et al.
Ming Guo et al.
Background: Although the randomized controlled trial (RCT) demonstrated that Xinyue capsule effectively reduced cardiovascular events within 1 year in stable coronary artery disease (CAD) patients post-PCI, the long-term ...
Amoebicidal action of isoliquiritigenin and glabridin from Glycyrrhiza species: Mechanisms and effects against Acanthamoeba castellanii [0.03%]
甘草中异甘草素和光果甘草素的溶阿米巴活性：卡氏棘阿米巴的作用机制和效果研究
Lijun Chen,Dai Dong,Wenwen Jing et al.
Lijun Chen et al.
Background: Acanthamoeba is a widely distributed genus, causing keratitis, granulomatous amoebic encephalitis and chronic infectious ulcers. At present, there are no effective drugs available for treating Acanthamoeba inf...
Alpha-Heredin targets CAMKⅡ/DRP1-Mediated mitochondrial fission to trigger ferroptosis in pancreatic ductal adenocarcinoma [0.03%]
α-赫瑞丁通过靶向CAMKⅡ/DRP1介导的线粒体分裂触发胰腺导管腺癌细胞铁死亡
Xin Li,Waimei Si,Yuan Zhang et al.
Xin Li et al.
Purpose: This study investigates the anti-tumor mechanisms of the natural triterpenoid Alpha-Heredin in pancreatic ductal adenocarcinoma, focusing on its dual effects on mitochondrial dynamics (via CAMKⅡ/DRP1 signaling) ...
Milk-processed Polygonatum cyrtonema Hua ameliorates cyclophosphamide-induced immunosuppression in mice by regulating gut microbiota and immune response [0.03%]
发酵黄精多糖通过调节肠道菌群和免疫反应缓解环磷酰胺所致小鼠免疫抑制作用
Yiwen Tao,Lijie Wang,Shuangfeng Xiong et al.
Yiwen Tao et al.
Background: Immune dysfunction is linked to the progression of various diseases. Milk-processed Polygonatum cyrtonema Hua (MPC) is a traditional medicine with nourishing effects in the Qinghai-Tibet Plateau region of Chin...
Qidong Huoxue decoction protects against acute lung injury by promoting SIRT1-mediated p300 deacetylation [0.03%]
气动血解毒方通过促进SIRT1介导的p300去乙酰化防治急性肺损伤
Yuhui Zhao,Xiao Shen,Na Li et al.
Yuhui Zhao et al.
Background: Qidong Huoxue Decoction (QD), a traditional Chinese medicine, has been used clinically to treat acute lung injury (ALI); however, its anti-inflammatory mechanisms remain poorly understood. ...
The mechanism of action in Mussaenda pubescens (Yuye Jinhua) against influenza A virus: Evidence from in vitro and in vivo studies [0.03%]
淫羊藿金花素YSJH02对流感病毒的作用机制：体内外研究证据
Jiaona Zhang,Bo Wu,Na Yang et al.
Jiaona Zhang et al.
Background: Influenza A virus (IAV) is recognized as a predominant etiological agent responsible for severe contagious diseases in both humans and animals, characterized by elevated pathogenicity and mortality rates. Muss...
Herbal mixture of Platycodon grandiflorum, Cinnamomum cassia, and Asiasarum sieboldii extracts protects against NASH progression via regulation of hepatic steatosis, inflammation, and apoptosis [0.03%]
北沙参、玄参与细辛提取物混合草药通过调节肝脂质积累、炎症和凋亡来预防NASH进展
Siqi Zhang,Hara Lee,Hong Ryul Ahn et al.
Siqi Zhang et al.
Background: Non-alcoholic fatty liver disease (NAFLD, recently renamed as metabolic dysfunction-associated steatotic liver disease [MASLD]) has emerged as one of the most prevalent chronic liver diseases globally. The mor...
Xiaoyaosan improves depression-like behaviours in mice with post-stroke depression by modulating gut microbiota and microbial metabolism and regulating P2X7R/NLRP3 inflammasome [0.03%]
逍遥散通过调节肠道菌群和微生物代谢及调控P2X7R/NLRP3炎性小体改善卒中后抑郁模型小鼠的抑郁样行为
Yue-Yue Chen,Yu-Ting Lu,Yi-di Wang et al.
Yue-Yue Chen et al.
Background: Post-stroke depression (PSD) represents the most prevalent complication of stroke and has been reported to be associated with an imbalance in the gut microbiota. Clinically, Xiaoyaosan (XYS) alleviates depress...
Rosmarinic acid attenuates hyperuricemia via restoring hyperuricemia-induced renal and intestinal dysfunctions [0.03%]
罗勒酸通过恢复高尿酸血症诱导的肾脏和肠道功能障碍来缓解高尿酸血症
Liyang Jia,Boyu Sun,Anzheng Nie et al.
Liyang Jia et al.
Background: The increasing incidence rate of hyperuricemia (HUA), a common chronic metabolic disease, seriously threatens public health. Previous studies have shown that rosmarinic acid (RA) has a good effect in lowering ...