Puerarin alleviates cerebral ischemia/reperfusion (CIR)-induced neurocyte oxidative stress and apoptosis via DNA demethylation-mediated PI3K/Akt activation [0.03%]
葛根素通过DNA去甲基化介导的PI3K/Akt激活缓解脑缺血再灌注损伤所致神经元氧化应激和凋亡
Guanfeng Xu,Jie Zhang,Chongyu Shao et al.
Guanfeng Xu et al.
Background: Cerebral ischemia stroke (CIS) is a multifactorial and heterogeneous neurological disorder characterized by high mortality rate and longterm cognitive deficits. Puerarin (Pue) exhibits neuroprotective properti...
Plant-derived exosomes: Unveiling the similarities and disparities between conventional extract and innovative form [0.03%]
植物源外泌体：传统提取物与创新形式的相似性与差异性探究
Xintong Han,Wenying Zheng,Zijun Sun et al.
Xintong Han et al.
Background: Herbal medicine, historically valued for its multi-component therapeutic synergy, faces significant challenges in clinical translation due to crude raw materials, compositional complexity, and low bioavailabil...
Nrf2/STAT3-mediated activation of SLC6A3 underlies the neuroprotective effect of quercetin in ischemic stroke [0.03%]
缺血性脑卒中中檞皮素的神经保护作用由Nrf2/STAT3介导的SLC6A3激活所介导
Huabao Cai,Meng-Yu Zhao,Cun-Zhi Wang et al.
Huabao Cai et al.
Background: Ischemic stroke (IS) is a leading cause of mortality and long-term disability, yet effective neuroprotective strategies remain limited. Oxidative stress and dopaminergic dysfunction are key contributors to neu...
Furongtongmai capsule alleviates neuroinflammation by downregulating the TLR4/MyD88/JNK pathway to promote the recovery of peripheral nerve compression [0.03%]
芙蓉通脉胶囊通过下调TLR4/MyD88/JNK信号通路缓解神经炎症促进糖尿病外周神经压迫修复
Huan Liu,Xuelei Zhang,Qifan Gu et al.
Huan Liu et al.
Background: Peripheral nerve compression disorders are characterized by neuroinflammation, local microcirculatory disturbances, and axonal damage. Current treatment modalities demonstrate limited efficacy in certain cases...
Micheliolide mitigates diabetic nephropathy by modulating oxidative stress and inflammation in rats [0.03%]
米契立醇通过调节大鼠氧化应激和炎症反应减轻糖尿病肾病
Chun Zhang,Borui Sun,Lianghe Wang et al.
Chun Zhang et al.
Background: Diabetic Nephropathy (DN) is a serious problem caused by diabetes mellitus (DM), and there are few effective treatments available. Purpose: ...
Danggui buxue decoction attenuates doxorubicin-induced cardiotoxicity by inhibiting ZBP1-mediated PANoptosis in vivo and in vitro [0.03%]
当归补血汤通过体内外抑制ZBP1介导的PANoptosis减轻多柔比星致心毒性
Lei Zhang,Hong-Wei Kong,Xu-Yu Song et al.
Lei Zhang et al.
Background: Cancer treatment may be hampered by doxorubicin (DOX)-induced cardiotoxicity (DIC), with limited therapeutic interventions currently available. PANoptosis, an inflammatory cell-death pathway, likely underlies ...
Shenling Tongqiao powder targets TGF-β1/Smad-Wnt/β-catenin axis to suppress epithelial-mesenchymal transition in chronic rhinosinusitis [0.03%]
Shen Ling Tong Qiao散通过靶向TGF-β1/Smad-Wnt/β-catenin轴抑制慢性鼻窦炎上皮间质转化
Kai Liu,Hui Zeng,Xiao Zhu et al.
Kai Liu et al.
Background: Chronic rhinosinusitis (CRS), a prevalent upper respiratory inflammatory disorder, remains challenging in clinical management due to the high recurrence rates. Traditional Chinese Medicine (TCM) pathogenesis t...
Combination of Withania coagulans and Fagonia cretica ameliorates hyperuricemia by re-modulating gut microbiota-derived spermidine and traumatic acid [0.03%]
Withania coagulans和Fagonia cretica的组合通过重新调节来源于肠道微生物群的腐胺和丁酸来改善高尿酸血症
Muhammad Naveed,Aamna Atta,Binqi Rui et al.
Muhammad Naveed et al.
Background: Hyperuricemia (HU), characterized by elevated serum uric acid (UA) levels, is associated with metabolic disorders, renal diseases, gout and gut dysbiosis. Withania coagulans (WC) and Fagonia cretica (FC) are m...
Fuzheng Jiedu granules for high-risk adults with COVID-19: A randomized, double-blind, placebo-controlled, multi-centre trial [0.03%]
新冠肺炎成人重症患者扶正救肺颗粒干预临床试验方案
Jingwei Shui,Xiaohua Xu,Yuntao Liu et al.
Jingwei Shui et al.
Background: Fuzheng Jiedu granules (FZJD) is widely used for COVID-19 in China, with early studies indicating reduced mortality in severe cases. However, with emerging variants and shifted treatment focus on preventing se...
Fuhu Lijie Tang treats rheumatoid arthritis through multitarget therapy from autoantigen formation to bone destruction [0.03%]
复鹿丽杰汤通过多靶点干预自身抗原形成至骨破坏治疗类风湿关节炎研究
Zhongliu Yao,Junjie He,Mingyue Hu et al.
Zhongliu Yao et al.
Background: Rheumatoid arthritis (RA) is an incurable, disabling autoimmune disease, and combination therapy with disease-modifying antirheumatic drugs targeting different pathological mechanisms is a therapeutic strategy...