Amygdalin alleviates MAFLD via inhibiting cytoplasmic calcium ion overload-induced liver sinusoidal endothelial cell defenestration [0.03%]
杏仁素通过抑制胞浆钙离子超载诱导的肝窦内皮细胞窗孔丧失来缓解MAFLD
Jiahao Wang,Lei Peng,Haoran Sun et al.
Jiahao Wang et al.
Background: Semen Persicae, a traditional Chinese medicine, has shown potential in alleviating metabolic dysfunction-associated fatty liver disease (MAFLD). However, the complexity of components limits its clinical applic...
Pharmacodynamic substance discovery and mechanism of action of Tibetan medicine Ba-Wei-Chen-Xiang San in spontaneously hypertensive rats [0.03%]
藏药八味沉香散活性成分筛选及降压机制研究
Danyang Wang,Haichao Li,Xinghao Zhu et al.
Danyang Wang et al.
Background: Ba-Wei-Chen-Xiang San (BWCX), a classic formula in Traditional Tibetan Medicine (TTM), has been historically employed for preventing and treating "Chalong" disorders, which correspond to cardiovascular disease...
Integrated analysis of network pharmacology and multi-omics reveals the mechanisms of Zuogui Jiangtang Qinggan formula ameliorates MASLD via fatty acid metabolic reprogramming [0.03%]
基于网络药理学和多组学的整合分析揭示六味地黄强肝颗粒通过脂肪酸代谢重编程改善非酒精性脂肪性肝病的作用机制
Junju Zou,Yuwei Dai,Yungfeng Yu et al.
Junju Zou et al.
Background: The global prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) continues to rise, and its pathogenesis is complex, creating an urgent need to discover novel and effective therapeutic...
The Scutellaria baicalensis-Coptis chinensis herb pair ameliorates ulcerative colitis via integrated modulation of the aryl hydrocarbon receptor/NLRP3 inflammasome axis with tryptophan metabolites [0.03%]
黄芩-黄连药对通过整合调节芳香烃受体/NLRP3炎性小体轴及色氨酸代谢物改善溃疡性结肠炎
Dan Fang,Xianjie Sheng,Xinru Li et al.
Dan Fang et al.
Background: The Scutellaria baicalensis Georgi and Coptis chinensis Franch (SC) herb pair constitutes a vital component in many classic formulas exhibited well-documented synergistic therapeutic efficacy against bacteri...
GSTM2 as the molecular linking of depression-driven colon cancer progression and chemoresistance: Reversal by Sinisan [0.03%]
GSTM2作为抑郁症驱动的结肠癌进展和化疗耐药分子联系：四磨汤逆转其作用
Na Li,Keying Chen,Bin Nie et al.
Na Li et al.
Background: Depression has emerged as a concerning factor in colon cancer progression and treatment, yet its underlying mechanisms and therapeutic targets remain poorly defined. ...
Anshen Bunao Syrup alleviates depression on CUMS rats by reducing neuroinflammation: Integral insights from transcriptomics, microbiomics, and metabolomics [0.03%]
安神补脑糖浆通过减少神经炎症来改善慢性不可预见性温和应激诱导的抑郁样行为：来自转录组学、微生物组学和代谢组学的综合见解
Xucong Huang,Shikai Yan,Fugen Li et al.
Xucong Huang et al.
Background: Anshen Bunao Syrup (ABS), a traditional Chinese medicinal formula, is widely used to treat neurological disorders such as insomnia, dizziness, and neurasthenia. However, its antidepressant effect and underlyin...
Tannic acid inhibits viral replication by disrupting nucleocapsid condensation [0.03%]
没食子酸通过破坏核衣壳凝聚抑制病毒复制
Jie Pan,Shao-Zhen Jiang,Yunkai Zhu et al.
Jie Pan et al.
Background: Viruses continue to threaten global health, highlighting the urgent need for antiviral strategies with broad-spectrum activity. The nucleocapsid (N) protein undergoes liquid-liquid phase separation (LLPS), a c...
Oxymatrine attenuates melanoma progression and metastasis through SORBS2-mediated suppression of M2 macrophage polarization [0.03%]
氧化苦参碱通过SORBS2介导的M2型巨噬细胞极化抑制作用来抑制黑色素瘤进展和转移
Xin Li,Yanhua Ou,Jinling Chen et al.
Xin Li et al.
Background: Melanoma is an aggressive malignancy characterized by a highly immunosuppressive tumor microenvironment (TME), in which tumor-associated macrophages (TAMs) play a key role. Although oxymatrine (OMT) has been s...
Pharmacological mechanisms of Yuxuebi tablet in alleviating neuropathic pain: Insights from network pharmacology, molecular docking, 16S rRNA sequencing, and metabolomics [0.03%]
愈血痹片药理机制缓解神经病理性疼痛的网络药理学、分子对接、16S rRNA测序及代谢组学研究见解
Xuanxuan Cheng,Qiumei Yang,Xiaojie Yuan et al.
Xuanxuan Cheng et al.
Background: Yuxuebi Tablet (YXBT) is a traditional Chinese patent medicine and is mainly used to treat joint swelling and pain associated with rheumatic arthritis and osteoarthritis. However, to date, no definitive clinic...
Prosapogenin CP4 and ursolic acid from Eriocapitella rivularis inhibit fluconazole-resistant Candida albicans synergistically by regulating Ras/cAMP/PKA pathway [0.03%]
Eriocapitella rivularis中的CP4原皂苷元和乌索酸通过调节Ras/cAMP/PKA途径协同抑制对氟康唑耐药的白色念珠菌
Wen-Biao Zu,Zhao-Jie Wang,Dong-Mei Tang et al.
Wen-Biao Zu et al.
Background: Fungal diseases affect over one billion individuals worldwide and represent a significant public health concern. Oral candidiasis (OC) is a common fungal infection primarily caused by Candida albicans. Eriocap...