Mangiferin attenuates Ang II-induced abdominal aortic aneurysm by blocking Lys591-mediated nuclear translocation of STAT3 [0.03%]
mango酸通过阻止Lys591介导的STAT3核转位来缓解血管紧张素II诱导的腹主动脉瘤形成
Shaopeng Cheng,Yilin Wang,Tingting Tong et al.
Shaopeng Cheng et al.
Background: Abdominal aortic aneurysm (AAA) is a lethal vascular disorder characterized by aortic dilation and medial degeneration, with no effective pharmacological interventions currently available. Pathological vascula...
Artesunate modulates the tumor microenvironment via STAT1/IRF1-mediated TAM repolarization and T cell activation in non-small cell lung cancer [0.03%]
.artesunate通过STAT1/IRF1介导的TAM重极化和T细胞活化调节非小细胞肺癌肿瘤微环境
Youfan Hu,Jingyi Tang,Haoyi Sun et al.
Youfan Hu et al.
Background: In non-small cell lung cancer (NSCLC), M2-polarized tumor-associated macrophages (TAMs) induce T cell dysfunction and correlate with poor clinical outcomes. Recent studies have demonstrated that artesunate (AS...
Schisandrol A-loaded mesenchymal stem cell exosomes modulate FTO/miR-21/WNT5A axis to promote skin healing [0.03%]
载有五味子醇A的间充质干细胞外泌体通过调节FTO/miR-21/WNT5A轴促进皮肤修复
Ming Hao,Boqiang Tao,Yanhong Luan et al.
Ming Hao et al.
Background: Schisandrol A (SA), the primary active component of Schisandra chinensis, exhibits antioxidant properties, safeguarding cells from oxidative damage. However, its effect on wound healing remains elusive, and it...
The sesquiterpene lactone estafiatin exerts an anti-inflammatory effect against Mycobacterium abscessus infection by regulating interleukin-1 beta production [0.03%]
塞斯菲亚丁通过调节白细胞介素-1β产生对胞壁缺损分枝杆菌感染发挥抗炎作用
Do-Hyeon Jung,Sang-Eun Jung,Tae-Sung Lee et al.
Do-Hyeon Jung et al.
Background: Mycobacterium abscessus, a species of non-tuberculous mycobacteria, is known to induce chronic pulmonary inflammation in humans. The nucleotide-binding oligomerization domain-like receptor family pyrin domain-...
Flemiphilippinin A induces paraptosis in lung cancer cells via c-Myc-driven endoplasmic reticulum stress and CHOP-mediated mitochondrial dysfunction [0.03%]
菲美菲宁A通过c-Myc驱动的内质网应激和CHOP介导的线粒体功能障碍诱导肺癌细胞发生类凋亡死亡
Zhipeng Xu,Xiaodong Huang,Qian Su et al.
Zhipeng Xu et al.
Background: Lung cancer persists as the foremost malignancy in terms of both incidence and mortality on a global scale. Paraptosis, a unique type of regulated cell death, differs from apoptosis in its reliance on protein ...
Exploring the therapeutic potential of phytochemicals: challenges and strategies for clinical translation [0.03%]
植物化学物质的治疗潜力探索：临床转化面临的挑战与策略
Hyo Keun Kim,Seong Jae Kim,Woo Jin Gil et al.
Hyo Keun Kim et al.
Background: Phytochemicals exhibit multi-target therapeutic potential with low toxicity, but their clinical translation is limited by poor bioavailability, unclear mechanisms, inadequate models, and structural instability...
Unraveling ancient wisdom: The molecular mechanism of Gujin Luyan Xuming decoction in combating cerebral ischemia-reperfusion injury [0.03%]
古今录验方治疗脑缺血再灌注损伤的分子机制研究
Yuzhe Cai,Yihui Deng,Jing Liu et al.
Yuzhe Cai et al.
Background: Cerebral infarction significantly impairs the quality of life of affected patients, emphasizing the need for research into novel targeted therapeutic agents. For nearly 2000 years, Gujin Luyan Xuming decoction...
Wuse-oil Compound 03 mitigates radiation-induced oral mucositis by modulating oral microbiota to mediate TLR4/NF-κB pathway and inhibit M1 macrophage polarization [0.03%]
Wu-Su油膏03通过调节口腔微生物群介导TLR4/NF-κB信号通路及抑制M1型巨噬细胞极化以缓解放射性口腔黏膜炎
Liqun Jia,Rong Huang,Chen Chen et al.
Liqun Jia et al.
Background: Radiation-induced oral mucositis (RIOM) is a prevalent condition among patients with head and neck cancer undergoing radiotherapy. It is characterized by a high incidence and severe symptoms that significantly...
M6PR upregulation by berberine attenuates hepatic senescence via sorting STING into endosome for degradation [0.03%]
黄连素通过诱导STING进入内吞体降解从而上调M6PR的表达以抑制肝脏衰老
Wenjuan Tang,Qianqian Zhang,Longyu Qin et al.
Wenjuan Tang et al.
Background: Cellular senescence is associated with various hepatic diseases. Stimulator of interferon genes (STING) signaling has been identified as a significant driver of cellular senescence and hepatic stellate cells (...
Bupleuri Radix polysaccharides enhance the efficacy and intestinal absorption of baicalin via regulating intestinal β-glucuronidase activity in MASH mice [0.03%]
柴胡多糖通过调节MASH小鼠肠β-葡萄糖醛酸酶活性增强黄芩苷的药效及肠道吸收效率
Anna Zhang,Siqi Gao,Conghua Shen et al.
Anna Zhang et al.
Background: Bupleuri Radix polysaccharides (BRP) and baicalin (BAI) are key coexisting constituents in the traditional Chinese medicine (TCM) pair Bupleuri Radix-Scutellariae Radix, a classical herbal pair widely used in ...