A polysaccharide from Pueraria lobata ameliorates hepatic fibrosis via gut microbiota-dependent suppression of ferroptosis [0.03%]
黄芪多糖通过依赖肠道菌群抑制铁死亡改善肝纤维化
Jiangping Wu,Zhu Yang,Lingzhi Chen et al.
Jiangping Wu et al.
Background: Hepatic fibrosis, driven by oxidative stress and subsequent hepatocellular injury, represents a major worldwide health challenge. Pueraria lobata Radix, a traditional Chinese herb, contains polysaccharides wit...
Senkyunolide I attenuates radiation-induced cognitive dysfunction by restoring PINK1-Parkin-mediated mitophagy and redox homeostasis [0.03%]
仙客来苷I通过恢复PINK1-Parkin介导的线粒体自噬和氧化还原稳态缓解放射引起的认知障碍
Tao Yan,Shun Guo,Song Zhang et al.
Tao Yan et al.
Background: Radiation-induced cognitive dysfunction (RICD) is a prevalent and long-term complication of cranial radiotherapy, characterized by hippocampal-dependent learning and memory impairment that severely compromises...
Deacetylation of PRDX1 contributes to alleviating acute liver injury through Dihydromyricetin-mediated SIRT1 upregulation [0.03%]
去乙酰化PRDX1通过SIRT1的上调介导二氢杨梅素缓解急性肝损伤的作用机制研究
Hong Hu,Chen Wang,Mengyan Chen et al.
Hong Hu et al.
Background: Acute liver injury (ALI) is a severe condition characterized by excessive hepatic inflammation and oxidative stress, yet effective therapeutic strategies remain limited. Dihydromyricetin (DMY), a natural flavo...
Schisantherin A alleviates DSS-induced colitis by upregulating ferredoxin 1 to inhibit inflammation and restore intestinal barrier function [0.03%]
石菖蒲素A通过上调铁氧还蛋白1防治葡聚糖硫酸钠诱导的结肠炎：抑制炎症及修复肠道屏障功能作用研究
Hongyu Xiao,Na Li,Jiangyan Rao et al.
Hongyu Xiao et al.
Background: Ulcerative colitis (UC) is a chronic non-specific inflammatory disease of the intestine with unknown etiology, and its effective treatments are still lacking. Repairing the intestinal mucosal barrier and reduc...
Scutellarin modulates Nrf2 to alleviate inflammation, pyroptosis, and ferroptosis in acetaminophen-induced hepatotoxicity [0.03%]
黄药素通过调节Nrf2减轻对乙酰氨基酚致肝毒性炎症、细胞焦亡和铁死亡作用机制研究
Rongli Pu,Qianxue Cui,Ziyi Xing et al.
Rongli Pu et al.
Background: Acetaminophen (APAP), one of the most commonly employed antipyretic analgesics worldwide, has paradoxically become a predominant cause of drug-induced liver injury (DILI) following overdose. The nuclear factor...
Wendan tablet and its active component isocurcumenol protect against myocardial ischemia via targeting ALOX15 and inhibiting lipid peroxidation [0.03%]
温丹胶囊及其有效成分异 Allocurcumeno 吡抑制 15- 环氧二十碳三烯酸环氧合酶并阻断脂质过氧化以保护心肌免受缺血损伤
Xiao-Hui Ma,Jiang-Han-Zi Liu,Chang-Lun Chen et al.
Xiao-Hui Ma et al.
Background: Wendan Tablet (WDT) is a traditional Chinese herbal compound formulation clinically employed in the management of coronary heart disease (CHD). ...
Quercetin alleviates liver injury in Wilson's disease by inhibiting ferroptosis [0.03%]
檞皮素通过抑制铁死亡缓解威尔森病肝损伤
Chenling Zhao,Guofang Yu,Mengying Zhang et al.
Chenling Zhao et al.
Background: Wilson's disease (WD) is characterized by pathological copper accumulation, primarily driving liver injury. While ferroptosis is implicated in metal toxicity, its role in WD and the therapeutic potential of Qu...
Novel BLT1 inhibitor baeckein E ameliorates LPS-induced acute lung injury through ferroptosis inhibition [0.03%]
新型BLT1抑制剂背榭因E通过抑制铁死亡改善脂多糖诱导的急性肺损伤
Yahui Mi,Rong Wang,Jianqiang Qian et al.
Yahui Mi et al.
Background and purpose: Acute lung injury (ALI) currently lacks targeted pharmacological therapies. Baeckein E, a natural compound from Baeckea frutescens l., has demonstrated anti-inflammatory and anti-lipid peroxidation...
Network pharmacology-guided self-assembling quercetin hydrogel from Astragalus membranaceous accelerates diabetic wound healing [0.03%]
基于网络药理学的膜荚黄芪自组装檞皮素水凝胶促进糖尿病伤口愈合研究
Meixuan Liu,Hanlei Zhou,Jialiang Wang et al.
Meixuan Liu et al.
Background: Delayed diabetic wound healing remains a significant clinical challenge. Astragalus membranaceus, a traditional Chinese herb, is widely used for the topical treatment of diabetic wounds. However, its complex c...
Current advances in restoring intestinal barrier homeostasis by natural medicines [0.03%]
天然药物修复肠屏障功能的最新研究进展
Yihan Wang,Sheng Tan,Jie Huang et al.
Yihan Wang et al.
Background: The intestinal mucosa serves as a critical interface separating the internal environment of the human body from the external milieu, with its barrier function determining the appropriate entry of luminal conte...