Identifying the natural compounds in Jinqian Xuduan Decoction for simultaneous uric acid lowering and chronic kidney disease amelioration [0.03%]
基于降尿酸和慢性肾脏病改善的前预测金钱愈脱素方活性成分筛选及网络分析研究
Hanfei Wang,Jieying Zhang,Boyu Wang et al.
Hanfei Wang et al.
Introduction: Hyperuricemia (HUA) and chronic kidney disease (CKD) are prevalent metabolic disorders worldwide. Current therapeutic approaches have inherent limitations, making the exploration and development of natural m...
Wenhui Zhou,Ali Asif,Chen Situ et al.
Wenhui Zhou et al.
Background: Berberine (BBR), a widely used monomer in traditional Chinese medicine, well-known for its extensive pharmacological activities against tumors, neurological disorders, and cardiovascular disease. These effects...
Traditional medicine Kuanxiong Aerosol alleviates atherosclerotic plaque inflammation by mitigating CX3CR1+ macrophage apoptosis via the cGAS-STING pathway [0.03%]
宽胸 aerosol通过cGAS-STING信号通路缓解CX3CR1+巨噬细胞凋亡从而抑制动脉粥样硬化斑块炎症作用及机制研究
Yefeng Chen,Guowei Wang,Yuanqing Jiang et al.
Yefeng Chen et al.
Background: Atherosclerosis (AS), a chronic inflammatory vascular disease, represents the leading cause of lethal cardiovascular events and demands innovative therapies targeting plaque inflammation. Kuanxiong Aerosol (KX...
Research progress on nanoplatforms based delivery of traditional Chinese medicine against multi-drug resistance in breast cancer [0.03%]
基于纳米平台的中医药递药系统抗乳腺癌耐药研究进展
Gangcui Li,Xianghui Duan,Yanan Zhou et al.
Gangcui Li et al.
Background: In the comprehensive clinical management of breast cancer, the emergence of multi-drug resistance often presents substantial challenges to effective drug therapy. Traditional Chinese medicine has shown great p...
Allium ursinum leaves aqueous extract alleviates Pseudomonas aeruginosa infection in Caenorhabditis elegans [0.03%]
蒲公英全叶水提取物可缓解铜绿假单胞菌对秀丽隐杆线虫的感染损伤
Kerstin Hangweirer,Georg Sandner,Alice König et al.
Kerstin Hangweirer et al.
Background: The rise of multidrug-resistant microorganisms primarily driven by the misuse and overprescription of antibiotics, is recognized as one of the top ten global health challenges. The identification of novel anti...
Corrigendum to "Chinese yam extract and adenosine attenuated LPS-induced cardiac dysfunction by inhibiting RAS and apoptosis via the ER-mediated activation of SHC/Ras/Raf1 pathway" [Phytomedicine 61 (2019) /152857] [0.03%]
“山药提取物和腺苷通过ER介导的SHC/Ras/Raf1途径抑制RAS和凋亡来减轻LPS诱导的心功能障碍”的勘误表 [Phytomedicine 61 (2019) /152857]
Mengnan Zeng
Mengnan Zeng
Polygonum hydropiper L. ethanol extract attenuates ferroptosis and ulcerative colitis by modulating glutathione metabolism through inhibition of KEAP1-Nrf2 interaction [0.03%]
蓼大青叶乙醇提取物通过抑制KEAP1-Nrf2相互作用调节谷胱甘肽代谢从而缓解铁死亡和溃疡性结肠炎
Dazhi Chen,Jian Liu,Huanjuan Yan et al.
Dazhi Chen et al.
Background: While ferroptosis inhibition in intestinal epithelial cells emerges as a novel therapeutic strategy for colitis, the scientific validation of Polygonum hydropiper L. - a traditional anti-inflammatory herb - re...
Albanol B inhibits glioblastoma progression by inducing senescence and apoptosis via the RNF6/p27 signaling axis [0.03%]
阿尔巴诺尔B通过RNF6/p27信号轴诱导衰老和凋亡从而抑制胶质母细胞瘤的进展
Jianbing Hou,Yi Du,Yaqian Shao et al.
Jianbing Hou et al.
Background: Glioblastoma, the most devastating type of glioma, is notorious for rapid proliferation, aggressive infiltration, angiogenesis, and treatment resistance. Identifying effective medicines or adjuvants for clinic...
Sophora Flos extract ameliorates inflammatory bowel disease via inhibiting the PI3K/AKT/mTOR signaling pathway activation and modulating M1/M2 polarization in macrophages [0.03%]
Sophora Flos提取物通过抑制PI3K / AKT / mTOR信号传导途径的活化和调节巨噬细胞中的M1 / M2极化来改善炎症性肠病
Anhong Li,Yuxiao Niu,Weihua Xu et al.
Anhong Li et al.
Background: Sophora flos (SF) is a medicinal plant with a rich history. Its principal bioactive constituents are flavonoids, which are known for their remarkable anti-inflammatory and antioxidant properties. Nevertheless,...
Dehydrotumulosic acid: a potential glucocorticoid receptor agonist with anti-coxsackievirus activity [0.03%]
脱氢松露酸：一种具有抗柯萨奇病毒活性的糖皮质激素受体激动剂
Jieyu Li,Yuanyuan Huang,Qiting Luo et al.
Jieyu Li et al.
Background: Coxsackievirus infections cause a range of diseases, from hand-foot-and-mouth disease to severe conditions such as myocarditis and meningoencephalitis. High mutation rates and serotype diversity complicate cli...