Primin inhibits New Delhi metallo-β-lactamase-5 and restores meropenem activity in Escherichia coli [0.03%]
普氏菌素通过抑制新德里金属β-内酰胺酶5型从而恢复碳青霉烯类抗生素对大肠杆菌的杀菌活性
Gaoqiang Wei,Yaozu Yang,Chunhua Wang et al.
Gaoqiang Wei et al.
Background: New Delhi metallo-β-lactamase-5 (NDM-5)-producing Escherichia coli is a major driver of carbapenem resistance, and clinically effective metallo-β-lactamase inhibitors remain unavailable. Primin (PRI), a benz...
Evaluating natural bioactive chronobiotics in a C. elegans circadian disruption system induced by light-temperature entrainment [0.03%]
利用光温同步诱导的小鼠和线虫生物钟紊乱模型筛选天然活性节律药物
Yiwen Guo,Tao Zhang,Ying Xu et al.
Yiwen Guo et al.
Background: The prevalence of circadian rhythm disruption (CRD) is increasing due to the worsening light pollution, rising societal stress, and globalized lifestyles. Long-term CRD can cause significant physiological chan...
Pien Tze Huang ameliorates alcohol-associated liver disease via suppressing oxidative stress and ferroptosis [0.03%]
皮太黄通过抑制氧化应激和铁死亡来改善酒精相关性肝病
Zhaomin Dong,Zhiwei Zhang,Ying Peng et al.
Zhaomin Dong et al.
Background: Alcohol-associated liver disease (ALD) is a major public health concern due to its increasing prevalence and lack of effective therapies. Pien Tze Huang (PTH) is a traditional Chinese medicinal formula commonl...
Phytotherapy for ageing-related multimorbidity: Systems-level insights into Centella asiatica in diabetes and Alzheimer's Disease [0.03%]
从系统层面探究锯齿草防治糖尿病和阿尔茨海默病的功效及机理
Sandesh Kumar Pattanaik,Debajani Mohanty,Asit Ray et al.
Sandesh Kumar Pattanaik et al.
Background: The increasing burden of age-related illnesses underscores the urgent necessity for integrative treatment approaches that simultaneously address the complex connections between metabolic and neurodegenerative ...
Betulinic acid induces lysosome-dependent death in prostate cancer by targeting DDX5 [0.03%]
白桦酸通过靶向DDX5诱导前列腺癌细胞溶酶体依赖性死亡
Shoushi Liu,Xiaolan Li,Zhiping Cheng et al.
Shoushi Liu et al.
Background: Prostate cancer (PCa) represents a leading cause of cancer-related mortality in men. Betulinic acid (BA) exhibits antitumor properties. However, its direct molecular target and mechanism in PCa remain unclear....
Ganoderic acid D alleviates vascular aging by restoring lysosomal function via stabilization of the VAPB-SNX25 tethering complex [0.03%]
灵芝酸D通过稳定VAPB-SNX25连接复合物恢复溶酶体功能从而缓解血管衰老
Haiying Zhang,Yu Chen,Zihan Zhong et al.
Haiying Zhang et al.
Background: Vascular smooth muscle cell (VSMC) senescence is a major driver of age-related vascular remodeling and functional decline, and is closely associated with lysosomal dysfunction. However, there remains a lack of...
Lisboaeflavanonol A: a novel Amazonian molecule as a potent antiviral compound with activity against SARS-CoV-2 [0.03%]
Lisboaeflavanonol A：一种新的亚马逊分子，具有针对SARS-CoV-2的强力抗病毒活性
Victória Riquena Grosche,Igor Andrade Santos,João Pedro Lima Sampaio et al.
Victória Riquena Grosche et al.
The COVID-19 pandemic highlighted the urgent need for effective antiviral therapies against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and its emerging variants. Amazonian biodiversity represents an immeasurable source of ...
Chlorogenic acid ameliorates ovarian aging in laying chickens by restoring lipid metabolism and steroidogenesis via the ERK/PPARα signaling pathway [0.03%]
氯ogenic酸通过恢复脂质代谢和类固醇生成来改善产蛋鸡的卵巢衰老的作用机制
Xiangyu Cai,Zhaoyu Yang,Yingyu Xiao et al.
Xiangyu Cai et al.
Background: Ovarian aging is characterized by progressive impairments of follicular development and reproductive performance. Increasing evidence indicates that metabolic dysregulation plays a central role in the decline ...
Single-nucleus RNA Sequencing and multi-omics reveal Uncaria-derived indole alkaloids induce hepatocyte injury by mediating CAR/PPARα axis [0.03%]
单细胞核RNA测序和多组学分析揭示钩藤类植物中吲哚生物碱通过介导CAR/PPARα轴诱导肝细胞损伤
Bin Yang,Xueqian Sun,Xinyue Zhang et al.
Bin Yang et al.
Background: Risk assessment and management of endogenous potentially toxic components are critical for promoting the rational clinical use of herbal medicines. However, most herbal medicines lack sufficient safety data in...
DangGui NianTong Decoction attenuates intervertebral disc degeneration by mitigating nucleus pulposus cell senescence and apoptosis through autophagy induction [0.03%]
当归拈痛汤通过诱导自噬减轻椎间盘细胞衰老及凋亡来延缓椎间盘退变的作用研究
Xu Yan,Ren-Jie Zhang,Yi-Bo Zhou et al.
Xu Yan et al.
Background: Intervertebral disc degeneration (IVDD) is a prevalent and debilitating condition characterized by loss of nucleus pulposus cells (NPCs) and degradation of the extracellular matrix (ECM). While the traditional...