Development of direct infusion quadrupole mass spectrometry database and intelligent identification system for 100 root herbs [0.03%]
基于100种根类药材的直接液相进样智能质量谱库建立及特征图谱快速识别方法研究
Jia-Wei Wang,Xiao-Kang Liu,Yan- Bo Xu et al.
Jia-Wei Wang et al.
Background: Counterfeiting is widespread in the herbal medicine market, especially for roots and rhizomes. Current authentication methods for these herbs remain limited and subjective, posing challenges to quality assuran...
Duhuo Jisheng decoction alleviates intervertebral disc degeneration by inhibiting nucleus pulposus cell ferroptosis via the exosome-mediated miR-19b-3p/ACSL4 axis [0.03%]
独活寄生汤通过外泌体介导的miR-19b-3p / ACSL4轴抑制髓核细胞铁死亡来缓解椎间盘退变
Jing Feng,Hongyan Miao,Zijun Xiao et al.
Jing Feng et al.
Background: Intervertebral disc degeneration (IVDD) is a major cause of spinal disorders, marked by nucleus pulposus cell (NPC) loss and extracellular matrix (ECM) degradation. Exosomes (EXOs), as nanoscale vesicles rich ...
Integrated bioinformatics and multi-omics reveal Astragalus extract's gut-kidney axis mechanism in hyperuricemic nephropathy via purine metabolism [0.03%]
基于黄芪的天然药物通过嘌呤代谢改善高尿酸血症肾病肠道-肾脏轴的整合生物信息学及多组学研究
Tingli Qu,Nan Zhang,Junjie Cai et al.
Tingli Qu et al.
Background: Astragalus has demonstrated clinical efficacy in treating renal diseases. However, its therapeutic potential in hyperuricemic nephropathy (HN) remains underexplored. ...
Columbianadin targets TRIM7 to maintain P2X7 palmitoylation, inhibiting cuproptosis in synovial M2 macrophages [0.03%]
哥伦比亚酸靶向TRIM7以维持P2X7棕榈酰化，抑制滑膜M2巨噬细胞中铜死亡
Zihao Li,Ziyu Huang,Xin Liao et al.
Zihao Li et al.
Background: Traumatic synovitis often arises from sports injuries, and early intervention is crucial for preserving joint health. Columbianadin (CBN), a natural phytochemical, has demonstrated efficacy in inhibiting infla...
Dihydrocapsaicin attenuates oxidative stress and apoptosis in acute myocardial infarction via promoting Raf-1/ASK1 complex formation [0.03%]
二氢辣椒素通过促进Raf-1/ASK1复合物的形成来减轻急性心肌梗死中的氧化应激和细胞凋亡
Yanmin Chen,Jiaying Yu,Hualing He et al.
Yanmin Chen et al.
Background: Acute myocardial infarction (MI) remains a leading cause of morbidity and mortality worldwide. Dihydrocapsaicin (DHC), a natural antioxidant derived from plants, has demonstrated pharmacological effects in var...
Mechanism of Eucalyptus oil in alleviating UUO-induced renal fibrosis revealed by transcriptomics and metabolomics [0.03%]
通过转录组学和代谢组学揭示尤加利精油缓解UUO诱导的肾纤维化的作用机制
Na Li,Huili Qi,Jiacun Li et al.
Na Li et al.
Background: Renal fibrosis (RF), a major contributor to the progression of chronic kidney disease (CKD), is an important therapeutic target. Eucalyptus oil (EO), a volatile extract derived from traditional Chinese herbal ...
Artificial intelligence combined with affinity chromatography discover that 7-Epitaxol promotes autophagy in NSCLC cells by interacting with EGFR: Discovery of novel EGFR antagonist based on DL and CMC [0.03%]
结合亲和色谱的人工智能发现7-表木蕊酮通过与EGFR相互作用促进NSCLC细胞自噬：基于DL和CMC的新型EGFR拮抗剂的发现
Haoyun Bai,Tong Wu,Yanni Lv et al.
Haoyun Bai et al.
Background: Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKI) are widely regarded as the most promising strategy to treat non-small cell lung cancer (NSCLC). While the existing development model canno...
Effect of berberine on herpes simplex keratitis through the dimerization of eukaryotic translation initiation factor 2-alpha kinase 2 [0.03%]
小檗碱通过激活蛋白激酶R样内质网激酶二聚体化发挥抗单纯疱疹病毒性角膜炎作用
Jinquan Lin,Haotong Wang,Xiaoyang Wei et al.
Jinquan Lin et al.
Background: Herpes simplex keratitis (HSK), primarily caused by corneal infection with herpes simplex virus type 1 (HSV-1), is a prevalent sight-threatening ocular disease. Eukaryotic translation initiation factor 2-alpha...
Alpha-tocopheryl quinone attenuates liver fibrosis through enriching Christensenella minuta and modulating bile acids metabolism via gut-liver axis [0.03%]
α-生育酚醌通过肠道-肝脏轴丰富Christensenella minuta并调节胆汁酸代谢从而缓解肝纤维化
Jing Chen,Lu Zhang,Yuyan Chen et al.
Jing Chen et al.
Background: Liver fibrosis, characterized by the progressive accumulation of excessive extracellular matrix (ECM), remains a major global health issue with limited treatment options. The gut-liver axis, particularly the d...
Neferine inhibits Zika virus replication by targeting viral protease [0.03%]
ネフェリンによるZIKV感染の抑制は、ウイルスプロテアーゼを標的として働くため
Senfeng Sun,Tingting Sun,Xinyu Lei et al.
Senfeng Sun et al.
Background: Zika virus (ZIKV) belonging to the Flaviviridae family causes critical neurological abnormalities, including congenital microcephaly and Guillain-Barré syndrome. Despite being a major public health concern, e...