Liposomal honokiol inhibits non-small cell lung cancer progression and enhances PD-1 blockade via suppressing M2 macrophages polarization [0.03%]
荷包膜honokiol抑制非小细胞肺癌进展并通过抑制M2型巨噬细胞极化增强PD-1阻滞作用
Yuan Cheng,Xuejiao Han,Xintian Lai et al.
Yuan Cheng et al.
Background: Honokiol (HNK), a natural phenolic compound derived from Magnolia plants, exhibits therapeutic effects on various diseases, including cancer. The advent of immune checkpoint inhibitors (ICIs) has marked a brea...
Corrigendum to "Mitigating phospholipid peroxidation of macrophages in stress-induced tumor microenvironment by natural ALOX15/PEBP1 complex inhibitors" [0.03%]
“应激诱导的肿瘤微环境中天然ALOX15/PEBP1复合体抑制剂缓解巨噬细胞磷脂过氧化”一文的勘误通知书
Xiang Luo,Dong-Dong Li,Zi-Chun Li et al.
Xiang Luo et al.
Gynostemma pentaphyllum saponins shield mice from peanut allergy by modulation of gut microbiota: A novel approach for peanut allergy management [0.03%]
绞股蓝皂苷通过调节肠道微生物群来保护小鼠免受花生过敏的影响：一种新的花生过敏管理方法
Xiaoang Li,Imran Khan,Ruixuan Han et al.
Xiaoang Li et al.
Background: Food allergies, particularly peanut (PN) allergies, are a growing concern, with fatal anaphylaxis incidents often reported. While palforzia is the sole FDA-approved drug for managing PN allergies, it is not un...
Metabolic pathways, pharmacokinetic, and brain neurochemicals effects of capsaicin: Comprehensively insights from in vivo studies [0.03%]
体内研究对辣椒素的代谢途径、药代动力学及脑神经化学物质影响的全面见解
Lulu Guo,Wu Fan,Die Li et al.
Lulu Guo et al.
Background: Capsaicin (CAP), a prominent component of chili pepper known for its potent agonistic effects on TRPV1, has attracted significant attention for its diverse physiological effects. Nevertheless, there remains a ...
Cycloastragenol reduces microglial NLRP3 inflammasome activation in Parkinson's disease models by promoting autophagy and reducing Scrib-driven ROS [0.03%]
环蜘蛛烷醇通过促进自噬和减少Scrib诱导的ROS生成来抑制帕金森病模型中的小胶质细胞NLRP3炎性体激活
Linjuan Feng,Hsuan Lo,Jiahao Zheng et al.
Linjuan Feng et al.
Background: In Parkinson's disease (PD), microglial autophagy is crucial for the maintenance of cellular redox homeostasis. Meanwhile, cycloastragenol (CAG), a triterpenoid saponin and the principal active component of As...
Icariin ameliorates Coxsackievirus B3-induced viral myocarditis by modulating the S100 calcium binding protein A6/β-catenin/c-Myc signaling pathway [0.03%]
淫羊藿黄酮主要通过淫羊霍素调节S100A6/β-cateninc-Myc信号通路改善柯萨奇病毒B3诱导的病毒性心肌炎
Huizhen Tian,Qigang Pan,Jianfeng Wu et al.
Huizhen Tian et al.
Background: Coxsackievirus B3 (CVB3) is a leading cause of viral myocarditis and is currently lacking specific pharmacological treatments, highlighting the critical need for therapeutic development. Icariin (ICA), a preny...
Hesperidin alleviated dendritic spines through inhibiting ferritinophagy via HERC2-NCOA4 ubiquitination in CUMS mice [0.03%]
柚皮素通过HERC2-NCOA4泛素化抑制铁死亡自噬从而缓解累积应激小鼠树突棘损伤
Mingjia Zhang,Yixuan Cui,Ruiting Jia et al.
Mingjia Zhang et al.
Background: Depression has been linked to ferritinophagy-induced synaptic damage, which affects the emotional circuitry and can ultimately lead to depressive symptoms. It has been suggested that Hesperidin might improve d...
Paeonol attenuates atherosclerosis by regulating vascular smooth muscle cells apoptosis and modulating immune cells infiltration through reducing LTβR expression [0.03%]
芍药醇通过减少LTβR的表达来调节血管平滑肌细胞凋亡和免疫细胞浸润从而达到抗动脉粥样硬化作用
Yuning Liang,Lishun Dong,Jinjin Yan et al.
Yuning Liang et al.
Background: Atherosclerosis is a chronic inflammatory disease with multicellular participation, and the decrease of plaque stability induces the occurrence of clinical adverse events. In order to update the clinical treat...
Regulation of NLRP3 inflammasome and Caspase-3/4/11 by 2',4'-dihydroxychalcone contributes to anti-colorectal cancer [0.03%]
2',4'-二羟基查尔酮通过调节NLRP3炎性小体和Caspase-3/4/11发挥抗结肠癌作用
Guohui Zhang,Yixin Yao,Zhongyu Zhang et al.
Guohui Zhang et al.
Background: Chronic inflammation is closely related to the occurrence and progression of many cancers, especially colorectal cancer (CRC), which can be triggered by repeated and sustained induction of colitis in mice. CRC...
Inhibition of colorectal cancer aggressiveness by Oleanolic acid through Nur77 degradation [0.03%]
白桦脂酸通过诱导Nur77降解抑制结直肠癌恶性进展
Shan Deng,Yuping Liu,Xiyu Liu et al.
Shan Deng et al.
Background: Colorectal cancer (CRC) is the second primary malignancy in China with tough treatment challenge. Although Oleanolic acid (OA) protects against various cancers, its mechanisms in CRC are not well defined. Our ...