Shexiang baoxin pill ameliorates cardiac fibrosis by inhibiting fibroblast to myofibroblast transition through STAT3 phosphorylation suppression [0.03%]
麝香保心丸通过抑制信号转导与转录激活因子STAT3磷酸化改善心肌成纤维细胞向肌成纤维细胞转化及心肌纤维化
Xuan Xu,Yanyi Tan,Shengnan Li et al.
Xuan Xu et al.
Background: Shexiang Baoxin Pill (SBP) is a traditional Chinese medicine used to treat ischemic cardiomyopathy. It can alleviate cardiac fibrosis following myocardial ischemia/reperfusion (MI/R) injury, but its action mec...
Atraric acid attenuates chronic intermittent hypoxia-induced brain injury via AMPK-mediated Nrf2 and FoxO3a antioxidant pathway activation [0.03%]
atraric酸通过AMPK介导的Nrf2和FoxO3a抗氧化途径激活缓解慢性间歇性缺氧引起的脑损伤
Mengxin Li,Jun Wang,Zihan Xu et al.
Mengxin Li et al.
Background: Obstructive sleep apnea syndrome (OSAS), a chronic disorder affecting approximately 10 % of adults worldwide with heightened prevalence in males and obese populations, induces irreversible neurocognitive impai...
Integrative multi-omics reveals that Salvia miltiorrhiza active fraction ameliorates rheumatoid arthritis in rats via inhibiting inflammation and ferroptosis [0.03%]
整合多组学分析揭示了丹参活性部位通过抑制炎症和铁死亡改善大鼠类风湿性关节炎
Zhaokun Yin,Shiqi Luo,Zhiyan Qin et al.
Zhaokun Yin et al.
Background: Rheumatoid arthritis (RA) is a chronic, highly disabling autoimmune disease requiring lifelong management, yet current therapies carry substantial long-term toxicity and high costs. Salvia miltiorrhiza is used...
Daurisoline inhibits pancreatic cancer progression by direct binding to PPARα and blocking its ubiquitination-mediated degradation [0.03%]
哒瑞斯林通过直接结合PPARα并抑制其泛素介导的降解来抑制胰腺癌进展
Dongchao Xu,Yuanling Zhu,Wuhan Ye et al.
Dongchao Xu et al.
Background: Pancreatic cancer (PC) is well known for its high lethality, and limited therapeutic options are currently available. Daurisoline (DAU), a bisbenzylisoquinoline alkaloid isolated from Menispermum dauricum DC.,...
Combined transcriptomics and network pharmacology to elucidate the mechanisms of rutin in treating ischemic stroke rat [0.03%]
结合转录组和网络药理学阐释芸香素治疗缺血性卒中大鼠的作用机制
Ting Zheng,Taotao Jiang,Yufeng Chen et al.
Ting Zheng et al.
Background: Ischemic stroke (IS) is a neurovascular disorder characterized by a prolonged treatment period and a high risk of recurrence. Rutin, a principal flavonol, has demonstrated potential neuroprotective effects in ...
Nordihydroguaiaretic acid (NDGA) exhibits potent anti-biofilm and antimicrobial activity against methicillin-resistant Staphylococcus aureus and Candida albicans [0.03%]
nordihydroguaiaretic酸（NDGA）对耐甲氧西林金黄色葡萄球菌和白色念珠菌具有强力的抗生物膜和抗菌活性
Xiangcheng Fan,Chunyan Dai,Jichun Han et al.
Xiangcheng Fan et al.
Introduction: The global rise of antimicrobial resistance (AMR), particularly among biofilm-forming bacteria and fungi, has created an urgent need for novel therapeutics. Nordihydroguaiaretic acid (NDGA), a plant-derived ...
Clinical outcomes and safety of Chinese herbal medicine in the treatment of hyperuricemia: A retrospective real-world study [0.03%]
中药治疗高尿酸血症的临床疗效及安全性：一项回顾性真实世界研究
Zilin Long,Houyu Zhao,Yueqi Yin et al.
Zilin Long et al.
Background: Hyperuricemia (HUA) has become a bothersome health problem that cannot be ignored. An increasing number of patients with HUA seek Chinese herbal medicine (CHM) as an alternative or complementary treatment. How...
Quercetagetin alleviates ischemic stroke injury by preserving macrophage/microglia homeostasis via inhibiting ACP5 [0.03%]
檞皮素通过抑制ACP5来维持巨噬细胞/小胶质细胞稳态，从而缓解缺血性卒中损伤
Chang Liu,Qi Wang,Enran Liu et al.
Chang Liu et al.
Background: The proinflammatory response triggered by macrophages/microglia plays a crucial role in the prognosis of acute ischemic stroke (AIS). Identifying novel targets to regulate the homeostasis of these cells is ess...
Moracin N alleviates ischaemic brain injury in mice by suppressing neuronal ferroptosis via the activation of the Keap1/Nrf2 signalling pathway [0.03%]
姜黄素N通过激活Keap1/Nrf2信号通路抑制神经元铁死亡从而缓解小鼠缺血性脑损伤
Jianbin Zhang,Qian Xia,Gaofeng Zhan et al.
Jianbin Zhang et al.
Background: Emerging evidence suggests that oxidative stress-induced lipid peroxidation ultimately results in ferroptosis, which contributes to the progression of ischaemic brain injury. Moracin N is a leading chemical pu...
Pathogenic mechanisms of cerebral ischemia and potential gut-brain axis-oriented therapeutic strategies [0.03%]
脑缺血的致病机制及潜在的肠-脑轴靶向治疗策略
Chumeng Zhuang,Qianqian Chen,Xiaotong Dou et al.
Chumeng Zhuang et al.
Background: Cerebral ischemia is a serious cerebrovascular disease, and its pathogenesis is complex and involves a variety of pathological processes. In recent years, the theory of gut-brain axis has provided a new resear...