An integrative analysis reveals mechanisms of Prunella vulgaris in thyroid cancer metastasis [0.03%]
整合分析揭示了石斛属紫花地丁（直序草属）在甲状腺癌转移中的机制
Shifan Zeng,Benjuan Liu,Rui Ge et al.
Shifan Zeng et al.
Background: Lymph node metastasis (LNM) in papillary thyroid carcinoma (PTC) is a major contributor to poor prognosis. Prunella vulgaris (P. vulgaris), a traditional medicinal herb, has shown potential in inhibiting PTC m...
Lycopene ameliorates Di-(2-ethylhexyl) phthalate-induced neurotoxicity in mice via the gut-brain axis [0.03%]
番茄红素通过肠-脑轴缓解Di-(2-乙基己基)邻苯二甲酸对小鼠的神经毒性作用
Li-Jian Chen,Yi Liu,Jia-Li Liu et al.
Li-Jian Chen et al.
Background: Di(2-ethylhexyl) phthalate (DEHP), a ubiquitous plasticizer present in numerous consumer products, poses a substantial neurotoxic risk through environmental and dietary exposure. Growing evidence highlights a ...
Integrated chemical composition, transcriptomics, and network pharmacology to reveal the mechanism of Jia-Wei-Si-Miao-Yong-An Decoction in ACS model rats [0.03%]
基于ACS模型大鼠的化学成分、转录组和网络药理整合研究加味四妙勇安汤治疗糖尿病足的作用机制
Ning Zhao,Mengya Dang,Yangyang Sun et al.
Ning Zhao et al.
Background: Acute Coronary Syndrome (ACS), as the most critical pathological type of coronary atherosclerotic heart disease, has a high morbidity and lethality, and the long-term treatment of modern medicine is still face...
Anxiolytic effects of corilagin by targeting Htr2c through activation of the TrkB/CREB/BDNF pathway [0.03%]
大黄素通过激活TrkB/CREB/BDNF通路靶向Htr2c产生抗焦虑作用
Xiaoyun Yun,Jianhui Wu,Jie Zhou et al.
Xiaoyun Yun et al.
Background: Anxiety disorders rank among the most ubiquitous neuropsychiatric disease classifications. Despite their substantial disease burden, the persistent lack of innovative, mechanistically grounded therapeutic inte...
Cistanoside F acts as a Monoacylglycerol Lipase inhibitor that synergizes the anti-tumor effect of 2-Arachidonoyl Glycerol on Bladder cancer [0.03%]
白花丹素F通过协同促进2-花生四烯酸甘油的抗肿瘤作用抑制单酰基甘油酶
Yu-Jun Tan,Yu-Shan Ren,Jun-Lin Lv et al.
Yu-Jun Tan et al.
Background: Bladder cancer (BCa) remains clinically challenging due to high recurrence rates. As an endocannabinoid, 2-arachidonoylglycerol (2-AG) plays a pivotal role in regulating numerous physiological and pathological...
Loganin epigenetically rescues mitochondrial complex III dysfunction via DNMT1-UQCRC1 demethylation to halt cardiac remodeling after myocardial infarction [0.03%]
loggentin通过DNMT1-UQCRC1去甲基化从机制上表观遗传学地解救线粒体复合物III功能障碍以在心肌梗死后阻止心脏重塑
Yunjing Wang,Renshan Chen,Huaqian Dou et al.
Yunjing Wang et al.
Background and purpose: Loganin, an iridoid glycoside from Cornus officinalis, exhibits cardioprotective potential. While previous studies focused on its antioxidant and anti-inflammatory properties, its role in myocardia...
Breviscapine injection and its main component scutellarin prevents lethal enterovirus infection by inhibiting neuroinflammation and oxidative stress in newborn mice [0.03%]
灯台叶注射液及其主要成分天仙子胺通过抑制新生小鼠神经炎症和氧化应激来预防致命的肠道病毒感染
Wenhui Yang,Junyi Wang,Yi Tao et al.
Wenhui Yang et al.
Background: Enterovirus 71 (EV71) is the primary cause of severe neurological infections associated with Hand, Foot and Mouth Disease (HFMD) in children, and no specific therapeutic agent is available. Breviscapine inject...
Butyrate-producing commensal bacteria mediates the efficacy of herbal medicine JCM-16021 on abdominal pain in diarrhea-predominant irritable bowel syndrome: a randomized clinical trial [0.03%]
产生丁酸的共生细菌介导了中药JCM-16021对腹泻型肠易激综合征腹痛疗效的作用：一项随机临床试验
Lixiang Zhai,Ya Zheng,Cho Wing Lo et al.
Lixiang Zhai et al.
Background: Irritable bowel syndrome with diarrhea (IBS-D) presents significant treatment challenges due to limited therapeutic options that effectively target the underlying pathophysiological mechanisms. In this study, ...
Coptisine activates aryl hydrocarbon receptor to regulate colonic epithelial homeostasis in DSS induced ulcerative colitis and TNF-α challenged intestinal organoids [0.03%]
黄连素通过激活芳香烃受体调节DSS诱导的溃疡性结肠炎和TNF-α刺激类器官中结肠上皮稳态
Bingyan Tan,Jingyan Zhang,An Kang et al.
Bingyan Tan et al.
Background: Coptisine is a bioactive isoquinoline alkaloid derived from Coptis Chinensis, exhibiting significant pharmacological potential. Emerging evidence suggests its therapeutic efficacy in gastrointestinal disorders...
Potential application of quercetin as an anti-diabetic treatment: From molecular mechanism to delivery system design [0.03%]
檞皮素作为糖尿病治疗药物的潜在应用：从分子机制到递送系统设计
Fang Liu,Binbin Zhao,Qi Wang et al.
Fang Liu et al.
Background: Quercetin, a natural flavonoid, has demonstrated protective effects against diabetes. Nevertheless, its poor aqueous solubility and chemical instability significantly hinder its clinical application. Nanoencap...