Mitochondrial pathways in rheumatoid arthritis: Therapeutic roles of traditional Chinese medicine and natural products [0.03%]
线粒体通路与类风湿关节炎：中药及天然产物的治疗作用
Hui Li,Shufan Fu,Ping Shen et al.
Hui Li et al.
Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation, cartilage destruction and systemic complications. Mitochondrial dysfunction has emerged as a critica...
Geniposidic acid alleviated metabolic dysfunction-associated steatotic liver disease by exciting SIRT6 signaling [0.03%]
补骨脂二素通过激活SIRT6信号通路改善代谢紊乱相关肝脂肪变性疾病
Yingya Zhou,Meng Feng,Hongyan Hai et al.
Yingya Zhou et al.
Background: Due to the absence of disease-modifying treatments and mysterious molecular causes, metabolic dysfunction-associated steatotic liver disease (MASLD) poses an urgent and unmet clinical need. The active ingredie...
Advances of Chinese medicine-derived exosomes in disease intervention and drug delivery system [0.03%]
基于中医药外泌体的疾病防治及药物递送系统研究进展
Xinning Zhang,Mengyu Chen,Haiting Zhu et al.
Xinning Zhang et al.
Backgrounds: Plant-derived exosome-like nanovesicles (PELNVs) are nanoscale vesicles with lipid bilayer as the basic framework, which include nucleic acids, encapsulate various proteins, and other bioactive substances. Th...
Celastrol derivatives ameliorate arthritis in AIA rats via modulating calcium signaling [0.03%]
雷公藤内酯衍生物通过调节钙信号改善AIA大鼠关节炎病情
Baixiong Huang,Jerome P L Ng,Dingqi Zhang et al.
Baixiong Huang et al.
Background: Calcium (Ca2+) signaling is implicated in the pathogenesis of rheumatoid arthritis (RA). Our previous study found that celastrol (CEL), a natural product derived from herbal plant Tripterygium wilfordii Hook F...
Rational combination of homoharringtonine to selectively target FLT3-ITD acute myeloid leukemia through synthetic lethality [0.03%]
合成致死作用介导的鬼臼毒素类生物碱联合靶向FLT3-ITD阳性急性髓系白血病研究
Ying Li,Xiaoxiao Gao,Huimin Zhang et al.
Ying Li et al.
Background: Homoharringtonine (HHT), a natural product used clinically to treat acute myeloid leukemia (AML) in combination with chemotherapy, induced transient remission in 25 % of unclassified AML patients when administ...
Gastrodin ameliorates DSS-induced ulcerative colitis via enhancing the abundance of Akkermansia muciniphila and modulating the metabolites [0.03%]
天麻素通过增加Akkermansia muciniphila丰度和调节代谢物来改善葡聚糖硫酸钠诱导的溃疡性结肠炎
Xinyu Zhang,Jiapei Cai,Lei Chen et al.
Xinyu Zhang et al.
Background: Ulcerative colitis (UC) is a chronic inflammatory condition of the colon. Gastrodia elata Blume (G. elata), a traditional herbal medicine from the Orchidaceae family, has notable anti-inflammatory effects. But...
Brusatol suppresses malignant progression of glioma via modulating the miR-574-5p/USP10/PLK1 axis [0.03%]
brusatol通过调控miR-574-5p/USP10/PLK1轴抑制胶质瘤恶性进展
Binbin Ma,Lei Wang,Jian Li et al.
Binbin Ma et al.
Background: Brusatol (BRU), a compound derived from Brucea javanica, has demonstrated notable antitumour activity across various cancer types. However, its precise mechanisms and functional roles in glioma remain incomple...
The Tanyu Tongzhi Formula enhances IL-10 expression and macrophage efferocytosis to alleviate atherosclerosis in mice [0.03%]
坦宇同治方通过上调IL-10表达促进巨噬细胞凋亡小体清除从而改善小鼠动脉粥样硬化病变
Chenxia Wu,Tiantian Zheng,Li Wu et al.
Chenxia Wu et al.
Background: Traditional Chinese Medicine (TCM), a significant subdiscipline within the realm of complementary medicine, has witnessed a surge in popularity across both Asian and Western nations over the past few decades. ...
Karanjin counteracts OVX-induced bone loss by dual regulating bone remodeling [0.03%]
卡拉金通过双重调节骨骼重塑来对抗卵巢切除引起的骨质流失
Qingliang Ma,Changzhen Li,Gengxiao Lin et al.
Qingliang Ma et al.
Background: Osteoporosis is a common skeletal disorder characterized by reduced bone mass and compromised bone microarchitecture. Although medicines have been developed for osteoporosis treatment, most of them focus eithe...
Astragaloside IV alleviates radiation-induced heart disease by regulating energy metabolism [0.03%]
Astragaloside IV通过调节能量代谢缓解放射性心病
Qiyang Li,Shangzu Zhang,Yangyang Li et al.
Qiyang Li et al.
Background: Radiation-induced heart disease (RIHD) has emerged as a critical complication compromising the long-term survival of cancer patients undergoing radiotherapy. Although targeting myocardial energy metabolism is ...