Echinacoside targets HSC70 to inhibit osteoclastogenesis and ameliorate ovariectomy-induced osteoporosis [0.03%]
埃chinacoside通过靶向HSC70抑制破骨细胞生成及改善卵巢切除术所致骨质疏松症
Dong Han,Qian-Tong Wu,Lei Wang et al.
Dong Han et al.
Background: Echinacoside (ECH), a natural phenylethanoid glycoside isolated from Cistanche deserticola, exhibits promising therapeutic potential against osteoporosis (OP). Nevertheless, its specific molecular targets and ...
Salvianolic acid B attenuates abdominal aortic aneurysm via inhibition of ferroptosis and inflammation [0.03%]
天冬酸B通过抑制铁死亡和炎症来缓解腹主动脉瘤
Si-Jia Jin,En-Guang Dou,Lei Wang et al.
Si-Jia Jin et al.
Background: Abdominal aortic aneurysm (AAA) is a life-threatening vascular disorder characterized by progressive aortic wall degeneration, inflammation, and vascular smooth muscle cells (VSMCs) loss. Despite extensive res...
Single-cell transcriptomics reveals the ameliorative effect of gastrodin on cholestatic liver fibrosis [0.03%]
单细胞转录组揭示丹参素改善胆汁淤积性肝纤维化的机制
Di Pan,Tian Zheng,Canping Chen et al.
Di Pan et al.
Background: Cholestatic liver diseases, such as primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC), and biliary atresia (BA), are characterized by bile accumulation and frequently progress to liver fi...
Reproductive toxicity of Fructus Psoraleae in zebrafish: material basis and implications for clinical safety dosing [0.03%]
补骨脂对斑马鱼生殖毒性的物质基础及其临床安全用药意义
Xin Shen,Rui Wang,Jun He et al.
Xin Shen et al.
Background: Fructus psoraleae (FP), a classical TCM with a medicinal history spanning several millennia, is esteemed for its therapeutic properties in regulating Qi, alleviating asthma, tonifying kidneys and reinforcing Y...
Ziziphora clinopodioides Flavonoids improve ischemic stroke by targeting FUNDC1-mediated mitophagy to reduce ferroptosis [0.03%]
Xingjie Zhuo,Shuxian Ding,Jinhua Li et al.
Xingjie Zhuo et al.
Background: Ischemic stroke (IS) is a major global cause of disability and death, with its complex pathophysiology posing a significant challenge for effective therapy. Although flavonoids from Ziziphora clinopodioides Fl...
Brusatol derivative ameliorates rheumatoid arthritis and atherosclerosis with associated suppression of mitochondrial fission [0.03%]
溴化饱和物衍生物通过抑制线粒体分裂改善类风湿关节炎和动脉粥样硬化
Ruicong Ma,Jiaqing Liu,Siwen Yang et al.
Ruicong Ma et al.
Background: Brusatol (BRU), a major bioactive quassinoid isolated from Brucea javanica, has shown potential in the treatment of inflammatory diseases. As mitochondrial dysfunction has been implicated in chronic inflammato...
Mechanistic study on the holistic actions of Hong-Hua-Xiao-Yao Tablet in alleviating premenstrual syndrome in rats [0.03%]
红花逍遥片治疗模型大鼠经前期综合征的机制研究
Wenjing Wei,Mingxiao Li,Kedian Chen et al.
Wenjing Wei et al.
Background: Premenstrual syndrome (PMS) is a cyclical neuroendocrine disorder that adversely affects the physical and mental health of women globally. Hong-Hua-Xiao-Yao Tablet (HHXYT) is a marketed Chinese patent medicine...
Farrerol mitigates fungal keratitis by enhancing fungal clearance and limiting inflammation through autophagy and Nrf2 pathway [0.03%]
ファー瑞醇通过自噬和Nrf2途径增强真菌清除和限制炎症来缓解真菌性角膜炎
Bing Yu,Lina Zhang,Jing Lin et al.
Bing Yu et al.
Background: Fungal keratitis is a vision-threatening corneal disease, in which uncontrolled inflammation and oxidative damage often result in poor clinical outcomes. Current antifungal drugs exert fungicidal activity but ...
Zedoarondiol regulates steatosis and inflammation in alcoholic liver injury via PTP1B-target mechanisms [0.03%]
丝裂素活化蛋白激酶激活的锌指转录共调节因子通过PTP1B靶向机制调节酒精性肝损伤中的脂肪变性和炎症
Jinru Zhu,Hui Wang,Ziyi Tang et al.
Jinru Zhu et al.
Background: Alcohol-associated liver disease (ALD) is a serious global health issue, often accompanied with steatosis and inflammation. Zedoarondiol (ZE), a natural guaiane-type sesquiterpene with antioxidant and anti-inf...
Polyphyllin VI induces Forkhead box O3 nuclear liquid-liquid phase separation to promote mitophagy in breast cancer [0.03%]
绞股蓝素VI通过促进FOXO3核凝聚相分离以增强线粒体自噬抑制乳腺癌进展
Xiangrong Zhan,Yifan Zhong,Xuewen Liu et al.
Xiangrong Zhan et al.
Background: Mitochondrial dysfunction and defective mitophagy are closely associated with cancer progression. Forkhead box O3 (FOXO3), a key transcription factor, promotes autophagy by activating autophagy-related genes. ...