Anti-quorum-sensing activity of Plectranthus aliciae in multispecies Cutibacterium acnes-Staphylococcus epidermidis systems [0.03%]
百里香精油通过抑制群体感应干扰多菌种痤疮丙酸杆菌和表皮葡萄球菌体系的合作效应
Isa A Kupke,Karl-Jan Spittaels,Tom Coenye et al.
Isa A Kupke et al.
Background: Quorum sensing (QS) is a bacterial communication process mediated by the production, release, and detection of autoinducers, regulating gene expression linked to virulence and biofilm formation. Cutibacterium ...
The purified extract of Cremastrae pseudobulbus pleiones pseudobulbus (EPC) induces mitochondrial apoptosis in hepatocellular carcinoma cells through inhibiting a key oncogenic signaling pathway [0.03%]
克氏盘管兰假鳞茎提取物通过抑制关键致癌信号通路诱导肝癌细胞线粒体凋亡
Jiayuan Li,Yu Wang,Renzhi Ma et al.
Jiayuan Li et al.
Background: Hepatocellular carcinoma (HCC) accounts for the majority of primary liver cancers and is associated with high incidence rate and high mortality rate. Cremastrae pseudobulbus pleiones pseudobulbus (CPPP) is com...
Rhubarb attenuates intracerebral hemorrhage injury by upregulating Snord17 to inhibit PANoptosis [0.03%]
大黄通过上调Snord17抑制PANoptosis从而减轻脑出血损伤
ZiLi Lai,Xindi Zhang,Jiao Li et al.
ZiLi Lai et al.
Background: Intracerebral hemorrhage (ICH) is the most severe subtype of stroke and currently lacks effective therapies. PANoptosis, a novel programmed cell death mode, plays an important role in ICH. Rhubarb has shown ne...
Corrigendum to "Cnicin promotes functional nerve regeneration" [Phytomedicine. 2024 Jul:129:155641] [0.03%]
“金莲花内酯促进功能神经再生”一文的勘误[Phytomedicine. 2024，129：155641]
Philipp Gobrecht,Jeannette Gebel,Marco Leibinger et al.
Philipp Gobrecht et al.
NOX2 inhibitor baicalein alleviates rheumatoid arthritis and inactivating mitochondrial oxidative stress-mediated cGAS-STING signaling in fibroblast-like synoviocytes [0.03%]
baicalein通过抑制NOX2缓解类风湿性关节炎和失活滑膜成纤维细胞线粒体氧化应激介导的cGAS-STING信号通路
Rui Wang,Weiming Fang,Yansheng Qiao et al.
Rui Wang et al.
Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease with a complex pathogenesis, leading to pain, disability, and even death. Baicalein, a constituent of Scutellaria baicalensis, has been identified as a...
Morus alba L. (Sangzhi) alkaloids reduce polycystic ovary syndrome by improving hypothalamic-pituitary-ovarian axis function [0.03%]
桑枝生物碱通过改善下丘脑-垂体-卵巢轴功能治疗多囊卵巢综合征
Yuanyuan Liu,Ruoyan Wu,Huijuan Li et al.
Yuanyuan Liu et al.
Background: Polycystic ovary syndrome (PCOS) is a neuroendocrine-metabolic disorder with no approved drugs. Hypothalamic-pituitary-ovarian (HPO) axis dysfunction is core pathogenesis, and metabolic heterogeneity complicat...
Mahuang Fuzi Xixin decoction attenuates allergic rhinitis by suppressing MHC-II-mediated antigen presentation in ovalbumin induced murine model [0.03%]
麻黄附子细辛汤通过抑制卵清蛋白致敏小鼠主要组织相容性复合体-Ⅱ介导的抗原呈递治疗过敏性鼻炎
Xiaohan Wei,Mengze Ding,Xiaomei Tan
Xiaohan Wei
Background: Allergic rhinitis (AR) is a chronic condition that impairs daily life and imposes economic burdens. Mahuang Fuzi Xixin Decoction (MFXD) is a commonly employed herbal formula in China for treating AR, owing to ...
Forsythia suspensa accelerates wound healing by inhibiting neutrophil extracellular traps and activating Wnt/β-catenin via forsythoside A [0.03%]
金银花通过抑制中性粒细胞胞外诱捕网并激活Wnt/β-连环蛋白信号通路促进伤口愈合
Guoguo Zhi,Haiyu Shen,Zihao Li et al.
Guoguo Zhi et al.
Background: Cutaneous wound repair is a complex biological process that restores the integrity of the skin. Forsythia suspensa (LQ) is a traditional Chinese medicinal herb known for its anti-inflammatory and antimicrobial...
Tongguanteng injection induces cell cycle arrest and drives ferroptosis through AURKA/KEAP1/NRF2 axis in breast cancer [0.03%]
tongguanteng注射通过AURKA / KEAP1 / NRF2轴诱导细胞周期停滞并驱动乳腺癌铁死亡
Hanlu Liang,Qixuan Ding,Jiayi Chen et al.
Hanlu Liang et al.
Background: Tongguanteng Injection (TGT), derived from the stems of Marsdenia tenacissima, has been demonstrated to exert anti-tumor effects. Aurora Kinase A (AURKA) is a key regulator of cell cycle progression and has be...
Targeting the mitochondrial-associated endoplasmic reticulum membrane to regulate calcium homeostasis: ShenfuYixin Granules counteract myocardial ischemia-reperfusion injury through the sGC/PKG pathway [0.03%]
针对线粒体相关内质网膜调节钙稳态：参附益心颗粒通过sGC/PKG通路对抗心肌缺血再灌注损伤
Xiaoyu Zhou,Shilong Li,Yingjie Cao et al.
Xiaoyu Zhou et al.
Background: Myocardial ischemia-reperfusion injury (MIRI) constitutes a significant contributor to the increased incidence of post-ischemic heart failure. The primary mechanisms underlying MIRI involve oxidative stress an...