Nasopharyngeal carriage of Staphylococcus aureus in a rural population, Sierra Leone [0.03%]
塞拉利昂农村人口的鼻咽部金黄色葡萄球菌携带率
Lisa Maria Kleine,Emmanuel Marx Kanu,Tobias Grebe et al.
Lisa Maria Kleine et al.
Background: Nasopharyngeal colonization with Staphylococcus aureus is a risk factor for subsequent infection. Isolates from colonization can therefore provide important information on virulence factors and antimicrobial r...
E. coli Nissle 1917 improves gut microbiota composition and serum metabolites to counteract atherosclerosis via the homocitrulline/Caspase 1/NLRP3/GSDMD axis [0.03%]
Ecoli Nissle 1917通过同瓜氨酸/Caspase 1/NLRP3/GSDMD轴改善肠道菌群组成和血清代谢物以对抗动脉粥样硬化
Huan Liu,Xiaofeng Ma,Xuefeng Yang et al.
Huan Liu et al.
Background: The probiotic E. coli Nissle 1917 (EcN) alleviates the progression of various diseases, including colitis and tumors. However, EcN has not been studied in atherosclerosis. The study investigated the effects of...
Signaling events driving Aspergillus fumigatus-induced eosinophil activation [0.03%]
驱动烟曲霉诱导嗜酸性粒细胞活化的信号事件
Jasmin Adam,Lisa-Marie Graf,Stefanie Westermann et al.
Jasmin Adam et al.
Allergic bronchopulmonary aspergillosis is an incurable disease caused by the environmental mold Aspergillus fumigatus. This hypersensitivity pneumonia is characterized by an inflammatory type 2 immune response, accompanied by influx of eos...
Aspergillus fumigatus sensu stricto genetic diversity from cystic fibrosis patients [0.03%]
来自囊性纤维化患者的严格意义烟曲霉遗传多样性
Aryse Martins Melo,Vanice Rodrigues Poester,Mariana Rodrigues Trápaga et al.
Aryse Martins Melo et al.
We aimed to access the genetic diversity of Apergillus fumigatus strains obtained from cystic fibrosis (CF) patients from southern Brazil. A. fumigatus sensu stricto isolates from respiratory clinical specimens were genotyped by microsatell...
Improved ability to utilize lactose and grow in milk as a potential explanation for emergence of the novel bovine Staphylococcus aureus ST5477 [0.03%]
利用乳糖能力和在牛奶中生长能力的提高可能是牛新发金黄色葡萄球菌ST5477出现的原因解释
Frank M Aarestrup,Egon B Hansen,Happiness H Kumburu et al.
Frank M Aarestrup et al.
Staphyloccous aureus belonging to sequence type 5477 have recently been identified as a predominant clone causing bovine mastitis in Rwanda and Tanzania. We compared nine S. aureus ST5477 to 17 isolates belonging to other sequence types by ...
Desiccation tolerance and reduced antibiotic resistance: Key drivers in ST239-III to ST22-IV MRSA clonal replacement at a Malaysian teaching hospital [0.03%]
耐干燥能力和降低的抗生素抗性：马来西亚教学医院中ST239-III克隆被ST22-IV克隆替代的关键驱动因素
Nurul Amirah Mohamad Farook,Silvia Argimón,Muttaqillah Najihan Abdul Samat et al.
Nurul Amirah Mohamad Farook et al.
Molecular surveillance of methicillin-resistant Staphylococcus aureus (MRSA) isolated from Hospital Canselor Tuanku Muhriz (HCTM), a Malaysian teaching hospital revealed clonal replacement events of SCCmec type III-SCCmercury to SCCmec type...
Genomic Analysis and Virulence Assessment of Hypervirulent Klebsiella pneumoniae K16-ST660 in Severe Cervical Necrotizing Fasciitis [0.03%]
基因组分析和高毒力肺炎克雷伯氏菌K16- ST660在严重颈部坏死性筋膜炎中的致病性评估
Jun Huang,Jiaru Zhuang,Lin Wan et al.
Jun Huang et al.
Objective: To investigate the source of infection in a patient with recurrent severe neck infections caused by Klebsiella pneumoniae and to analyze the virulence of isolates obtained from different sites of the patient. ...
Co-transcribed genes SA1833-SA1832 promote persister formation by regulating the transcription of holin-like gene lrgA in methicillin-resistant Staphylococcus aureus strain N315 [0.03%]
金黄色葡萄球菌耐甲氧西林株N315中共同转录的SA1833-SA1832基因通过调节holin样基因lrgA的转录促进休眠态形成
Shiwen Xu,Jiade Zhu,Yujie Li et al.
Shiwen Xu et al.
Staphylococcus aureus, a facultative anaerobic gram-positive bacterial pathogen, has posed major threat to public health worldwide. Upon S. aureus infection, the host immune system is activated for clearance. However, intracellular S. aureu...
In silico analysis and functional characterization of a leucine-rich repeat protein of Leptospira interrogans [0.03%]
里氏利斯特菌富亮氨酸重复蛋白的生物信息学分析及功能鉴定
João P Gaspar,Maria B Takahashi,Aline F Teixeira et al.
João P Gaspar et al.
Pathogenic spirochetes of the genus Leptospira are the causative agent of leptospirosis, a widely disseminated zoonosis that affects humans and animals. The ability of leptospires to quickly cross host barriers causing infection is not yet ...
Functional profiling of CHAP domain-containing peptidoglycan hydrolases of Staphylococcus aureus USA300 uncovers potential targets for anti-staphylococcal therapies [0.03%]
金黄色葡萄球菌USA300型肽聚糖水解酶的CHAP结构域功能谱系分析发现了潜在的抗葡萄球菌疗法目标
Min Wang,Xiaofang Li,Francis M Cavallo et al.
Min Wang et al.
The bacterial pathogen Staphylococcus aureus employs a thick cell wall for protection against physical and chemical insults. This wall requires continuous maintenance to ensure strength and barrier integrity, but also to permit bacterial gr...