Gain-of-function mutation in the sensor kinase CpxS modulates the antimicrobial resistance and virulence of Pseudomonas aeruginosa [0.03%]
囊性纤维化感染病原铜绿假单胞菌调控抗生素抗性和毒力的增益型突变机制研究
Xueqin Xie,Yilin Chen,Xinyao Li et al.
Xueqin Xie et al.
The CpxRA two-component system is a key regulator of envelope stress responses in Gram-negative bacteria. In this study, a gain-of-function mutant in Pseudomonas aeruginosa was generated by truncating the periplasmic sensing domain (PSD) of...
Mycobacterium tuberculosis identification and antibiotic resistance gene profiling using nanopore sequencing: A new approach for tailoring more effective treatments for patients [0.03%]
纳米孔测序鉴定结核杆菌并进行抗生素耐药基因分型：为患者量身定制更有效的治疗方法的新方法
Gen Li,Ao Wu,Mingquan Guo et al.
Gen Li et al.
Rapid diagnosis of TB infections and effective drug treatment is central to reducing disease morbidity and mortality. Here we evaluate the performance of TBseek, a multiplex targeted PCR nanopore sequencing-based test designed for TB identi...
Epidemiology and population structure of Acinetobacter baumannii outbreak in a COVID-19 concentration center [0.03%]
一起在COVID-19临时集中隔离点爆发的鲍曼不动杆菌的流行病学和群体结构分析
Elena Cercas-Ayala,Nadia Rodríguez-Medina,Christian Daniel Mireles-Dávalos et al.
Elena Cercas-Ayala et al.
Coronavirus disease caused by the SARS-CoV-2 has become one of the most significant global health challenges. The coinfections in patients with COVID-19 are considered an important risk factor. The Instituto Nacional de Enfermedades Respira...
Herpes simplex virus 1 UL2 protein inhibits RIG-I-like receptor pathway-induced IFN-β activity by disrupting IRF3 activation [0.03%]
单纯疱疹病毒1型UL2蛋白通过破坏IRF3活化抑制RIG-I样受体通路诱导的IFN-β活性
Meili Li,Danna Chen,Chunyan Xu et al.
Meili Li et al.
Herpes simplex virus 1 (HSV-1) is a member of alphaherpesvirus that can cause some important human diseases, and type I interferon (IFN-I)-mediated antiviral effect plays a vital role in the innate immune response, whereas this reaction can...
Advancing genomic surveillance of respiratory syncytial virus in Portugal through an adapted amplicon-based whole-genome sequencing workflow [0.03%]
通过改良的扩增子基因组测序流程推进葡萄牙呼吸道合胞病毒的基因组监测工作
Miguel Lança,Vítor Borges,Vânia Gaio et al.
Miguel Lança et al.
Background: Respiratory syncytial virus (RSV) poses a significant global health burden, especially among young children. Whole-genome sequencing (WGS) is key for tracking RSV evolution and epidemiology, underscoring the i...
Integrative analysis of toxin-antitoxin systems, genomics, and phenotypic traits reveal phylogroup-dependent diversity among ExPEC bloodstream isolates [0.03%]
整合分析毒菌剂-抗毒素系统、基因组学和表型特征揭示尿源性ExPEC菌血症分离株的多样性依从进化谱系分布
Thais Mitsunari,Jessika C A Silva,Alejandra M G Del Carpio et al.
Thais Mitsunari et al.
Extraintestinal pathogenic Escherichia coli (ExPEC) causing bloodstream infections encompass diverse evolutionary lineages with distinct genomic and pathogenic traits. Here, we applied an integrative strategy combining population-level anal...
G-CSF enhances neutrophil function with potential involvement of INHBA during Aspergillus fumigatus infection [0.03%]
G-CSF通过潜在的INHBA作用增强中性粒细胞功能以对抗烟曲霉感染
Wenxin Zhang,Haitao Wang,Majid S Jabir et al.
Wenxin Zhang et al.
Introduction: Aspergillus fumigatus causes life-threatening infections in immunocompromised individuals. Neutrophils are essential for antifungal defence, but their function is often impaired in these patients. Granulocyt...
Evolutionary dynamics of drug resistance in MDR-TB: Heterogeneous minor variants and extensive compensatory mutations [0.03%]
耐多药结核病药物抵抗的进化动态：异质性少数突变和广泛的补偿突变
Lei Chen,Shaojun Pei,Chunqi Yu et al.
Lei Chen et al.
Multidrug-resistant Mycobacterium tuberculosis complex (MTBC) remains a major global health challenge, yet the drug-specific evolutionary pathways through which resistance accumulates are not fully understood. Heterogeneous minor resistant ...
Corrigendum to "Emergence of novel sublineages of Mycobacterium tuberculosis in Pakistan" [Int. J. Med. Microbiol. 321 (2025) 151684] [0.03%]
“巴基斯坦出现新型分支结核分枝杆菌”的勘误通知(International Journal of Medical Microbiology论文)
Muhammad Tahir Khan,Chendi Zhu,Arwa Omar Al Khatib et al.
Muhammad Tahir Khan et al.
A real-time PCR assay for detection of Rickettsia rickettsii to aid in vivo infection monitoring [0.03%]
一种用于检测立克次体的实时PCR测定法有助于活体内感染监测
Ian Matthew Stoll,Perle Latré de Laté,Roman Reddy Ganta
Ian Matthew Stoll
Rocky Mountain spotted fever (RMSF) is an important and potentially fatal tick-borne disease impacting people and dogs. RMSF, caused by Rickettsia rickettsii, is frequently reported in parts of the North, Central and South American countrie...