EBV encoded tegument protein BKRF4 suppresses RLR signaling pathway-mediated interferon production through inhibiting the activation of IRF3 and IRF7 [0.03%]
EB病毒编码的BKRF4蛋白通过抑制IRF3和IRF7活化来抑制RLR信号通路介导的I型干扰素产生
Meili Li,Xinghong Gao,Danna Chen et al.
Meili Li et al.
Epstein-Barr virus (EBV), a member of gamma herpesvirus subfamily, infects more than 90% of the people in the world. There are some studies on EBV-mediated regulation of type I interferon (IFN-I) signaling, however, the underlying mechanism...
Virulent phages MM-1 and MM-2 attack enterohemorrhagic Escherichia coli and Salmonella enterica strains [0.03%]
噬菌体MM-1和MM-2可侵袭肠致病性大肠杆菌及沙门氏菌菌株
Marina Macho,Vera von Hamm,Herbert Schmidt et al.
Marina Macho et al.
Enterohemorrhagic Escherichia coli (EHEC) are important human pathogens causing serious human diseases such as bloody diarrhea, hemorrhagic colitis and hemolytic-uremic syndrome (HUS). In recent years, the consumption of minimally processed...
Increased survival of Staphylococcus aureus co-cultured with Gram-negative pathogens against antibiotics [0.03%]
革兰氏阴性病原体提高耐甲氧西林金黄色葡萄球菌的抗生素耐受性
Hee Won Han,Min Seok Kim,Kwan Soo Ko
Hee Won Han
Polymicrobial infections are known to be associated with increased infection severity and poor clinical outcomes. In this study, we investigated the effect of co-infection with Gram-negative bacteria on the survival of Staphylococcus aureus...
The impact of the hly gene deletion on biofilm formation and antibiotic sensitivity in Listeria monocytogenes [0.03%]
hly基因敲除对单增李斯特氏菌生物被膜形成及药物敏感性的影响
Yadi Li,Huan Qin,Rongfang Guo et al.
Yadi Li et al.
Listeria monocytogenes (L. monocytogenes) is a pathogenic bacterium that poses a significant threat in food safety due to its ability to form resilient biofilms, contributing to cross-contamination risks in food processing environments. Thi...
Strain-specific variation in virulence and host-immune modulation across the Cryptococcus gattii species complex [0.03%]
克柔念珠菌复合群中不同血清型毒力及宿主免疫调控的差异性研究
Virginie Bellet,Léo Brochon,François Chable de la Héronnière et al.
Virginie Bellet et al.
Cryptococcus gattii is an environmental yeast capable of causing severe infections in immunocompetent hosts. Its virulence mechanisms remain less characterized than those of C. neoformans. This study aimed to evaluate the expression of majo...
Prevalence and antimicrobial resistance of Acinetobacter baumannii isolates at Lebanese Hospital Geitaoui-University Medical Center: A Five-year study (2017-2021) [0.03%]
2017年至2021年黎巴嫩医院吉泰奥大学医学中心不动杆菌的流行率和抗微生物药物耐药性五年研究
Ghassan Ghssein,Jana Al Ariss,Taghrid Chaaban et al.
Ghassan Ghssein et al.
Objectives: Acinetobacter baumannii is a critical opportunistic pathogen known for causing serious healthcare-associated infections and exhibiting alarming levels of antimicrobial resistance. This study aims to determine ...
Transcriptomic and functional evidence reveals dual-module immune response of human-nasal staphylococcus aureus in Koi Carp (Cyprinus carpio) [0.03%]
转录组和功能证据揭示了鲤鱼(S Spotteled)中人类鼻咽部金黄色葡萄球菌的双模块免疫反应
Mei Li,Zeqing Xu,Jiarui Zeng et al.
Mei Li et al.
Staphylococcus aureus is a significant pathogen that poses a threat to both human and animal health. Its pathogenicity in humans has been extensively studied, however, the signaling pathways and key genes in Koi Carp responding to S. aureus...
mNGS-guided precision management of M. pneumoniae pneumonia: Pathogen load assessment and fungal co-detection patterns directing antibiotic optimization [0.03%]
基于mNGS的肺炎支原体肺炎精准管理：病原载量评估及真菌合并感染指导抗生素优化方向
Jiayin Li,Haiting Wei,Shuaifeng Wang et al.
Jiayin Li et al.
Background: Global Mycoplasma pneumoniae pneumonia (MPP) outbreaks show increasing refractory cases. Conventional diagnostics lack sensitivity, with limited evidence on factors affecting M. pneumoniae load in mNGS, co-det...
Characterization and antibiofilm efficacy of the Pseudomonas aeruginosa phage HKPH_J3 [0.03%]
铜绿假单胞菌噬菌体HKPH_J3的特性及抑菌膜活性分析
Jinyue Zhang,Yao Li,Tianheng Xue et al.
Jinyue Zhang et al.
In recent years, due to the spread of antibiotic resistance, Pseudomonas aeruginosa has emerged as an ESKAPE super-resistant pathogen, posing a major threat to current therapies. Phage therapy is currently one of the most promising treatmen...
Resistome, virulome and mobilome of clinical carbapenemase-producing Acinetobacter baumannii strains isolated in Togo [0.03%]
分离于多哥的临床产碳青霉烯酶鲍曼不动杆菌菌株的耐药基因组、毒力基因组和可移动基因组
Sika Dossim,Komla M Dossouvi,Amivi M Godonou et al.
Sika Dossim et al.
Genomics have become crucial in addressing the public health challenges posed by antimicrobial resistance (AMR). In this study, we performed the first whole-genome sequencing (WGS) and genomic analyses of clinical Acinetobacter baumannii (A...