A pan-azole and pan-echinocandin resistant Wickerhamomyces anomalus isolate causing bloodstream infection: ERG11Y140F, K151R with copy number variation and FKS1F665S mutation [0.03%]
一种引起血流感染的对各类唑类和棘白菌素耐药的异常汉逊酵母：ERG11Y140F，K151R拷贝数变异及FKS1F665S突变
Zhengyu Luo,Yating Ning,Rongchen Dai et al.
Zhengyu Luo et al.
Fungal infections pose a growing global threat, particularly due to the emergence of multidrug-resistant pathogens. This study reports the first globally documented case of a Wickerhamomyces anomalus isolate (XN272) displaying dual high-lev...
Emergence of KL57 hypervirulent Klebsiella pneumoniae in Wuxi, China: Genomic insights into virulence plasmid evolution and blaKPC-2-bearing IncFIIK34 plasmid transmission [0.03%]
中国无锡地区KL57型高毒力肺炎克雷伯菌的出现及毒力质粒进化和blaKPC-2携带IncFIIK34型质粒传播的基因组学研究
Yutong Liu,Lin Wan,Xiong Li et al.
Yutong Liu et al.
Objective: KL57 Klebsiella pneumoniae (K. pneumoniae) is an emerging serotype with epidemiological characteristics and pathogenic mechanisms that remain incompletely understood. This study comprehensively analyzed the gen...
Emergence and genetic heterogeneity of STEC O113:H4: insights from whole-genome sequences of isolates across human and non-human sources [0.03%]
STEC O113:H4的出现和遗传异质性：来自人类及动物来源分离菌完整基因组序列的见解
Florence Crombé,Frederic Auvray,Angela H A M van Hoek et al.
Florence Crombé et al.
The increased detection of Shiga toxin-producing Escherichia coli (STEC) O113:H4 among human cases in Belgium questions the importance of this serotype as an emerging pathogen. However, detailed information focusing on serotype O113:H4 from...
Distribution and antimicrobial resistance of Acinetobacter spp. isolated from different types of clinical specimens from hospitalized patients and outpatients in Poland [0.03%]
波兰住院及门诊患者不同临床标本中不动杆菌的分离分布和耐药性分析
Tomasz Kasperski,Monika Pobiega,Monika Pomorska-Wesołowska et al.
Tomasz Kasperski et al.
Background: Acinetobacter baumannii (AB) is the most frequently isolated nosocomial pathogen, but severe infections by A. pittii, A. ursingii, and A. bereziniae are increasing. This study investigated the distribution and...
Clinical characteristics and whole-genome analysis of methicillin-resistant Staphylococcus aureus in ICU patients from a tertiary hospital in southern China [0.03%]
中国南部一家三级医院ICU患者中耐甲氧西林金黄色葡萄球菌的临床特征和全基因组分析
Ying Wang,Zhihan Xiao,Huimin Xi et al.
Ying Wang et al.
Objectives: This study aimed to characterize the molecular epidemiology, antimicrobial resistance, virulence profiles, and clinical outcomes of Methicillin-resistant Staphylococcus aureus (MRSA) infections among intensive...
Virulome and genome-wide association study of vancomycin-resistant Enterococcus faecium from bloodstream infections versus colonization isolates [0.03%]
源自血流感染和定植的肠球菌菌株的毒力基因组及全基因组关联研究
Christian W Böing,Julia S Schneider,Neele J Froböse et al.
Christian W Böing et al.
Introduction: Vancomycin-resistant Enterococcus faecium (VREfm) are multidrug-resistant pathogens that cause severe nosocomial infections. The knowledge of virulence profiles of VREfm for the development of invasive infec...
Muhammad Tahir Khan,Chendi Zhu,Arwa Omar Al Khatib et al.
Muhammad Tahir Khan et al.
Introduction: Understanding the distribution and prevalence of different M. tuberculosis lineages can help public health authorities and researchers track the spread of tuberculosis (TB). Some lineages are thought to be m...
A large outbreak investigation of Legionnaires' disease associated with a public bath facility in Hiroshima, Japan, using PFGE, SBT, MLVA, and whole-genome sequencing [0.03%]
日本广岛一起与公共浴场有关的大规模军团病暴发事件的流行病学调查：PFGE、SBT、MLVA和全基因组测序分析
Takahiro Hiratsuka,Noriko Nakanishi,Hiroko Akita et al.
Takahiro Hiratsuka et al.
In 2017, a large outbreak of Legionnaires' disease, involving 58 patients, occurred in a public bath facility in Hiroshima Prefecture, Japan. We analyzed 94 Legionella pneumophila strains isolated from patients and the public bath facility ...
Complete genome and comparative genomic analysis of cefpodoxime resistant Pantoea septica strain GABEPS69 isolated from saliva of a patient diagnosed with treatment resistant schizophrenia [0.03%]
一株从难治性精神分裂症患者唾液中分离出的头孢泊肟耐药植物病原菌泛菌属的新种GABEPS69基因组及比较基因组分析
Francesca McDonagh,Aneta Kovarova,Anna Tumeo et al.
Francesca McDonagh et al.
Objectives: This study aims to generate the first complete genome of Pantoea septica and provide a thorough genomic characterisation of this under-documented species. The study seeks to enhance understanding of P. septica...
Differential expression profile of streptolysin S in the covR and covS mutants of group A Streptococcus is a mediator of keratinocyte death and aggressive local infection [0.03%]
链球菌CovRS双基因突变体中链球菌溶素S的差异表达谱是调节角质形成细胞死亡和局部感染的重要介质
Yong-An Shi,Hang Kim Nguyen,Pei-Jane Tsai et al.
Yong-An Shi et al.
Group A Streptococcus (GAS) isolates with spontaneous mutations in covR and covS are frequently identified in patients with necrotizing fasciitis and toxic shock syndrome. CovR/CovS is a two-component regulator system, and the phosphorylati...