Clinical utility of bronchoalveolar lavage fluid metagenomic next-generation sequencing in the etiological diagnosis of community-acquired pneumonia in children [0.03%]
儿童社区获得性肺炎病原学诊断中支气管肺泡灌洗液宏基因组测序的临床应用价值研究
Rongjie Chen,Zhengdong Li,Dengran Li et al.
Rongjie Chen et al.
CAP is a major cause of pediatric hospitalization on a global scale, particularly in developing countries where the morbidity and mortality rates remain high. The etiological diagnosis of CAP in children is challenging, particularly for chi...
Sequence variability of Hungarian RSV G and F proteins between 2017 and 2023: single-center study [0.03%]
匈牙利2017年至2023年间RSV G和F蛋白的序列变异：单中心研究
Hajnalka Juhász,Katalin Burián,Mátyás Bukva et al.
Hajnalka Juhász et al.
Our study determined the prevalence, types of RSV, and sequence variability of the G and F genes in Hungary between 2017 and 2023. During the study, 1828 respiratory samples were collected from hospitalised pediatric patients. We confirmed ...
Epidemiology of multidrug resistant E. coli isolates from a German university hospital illustrates dominance of E. coli ST131 [0.03%]
德国大学医院多重耐药的大肠杆菌疫病流行显示大肠杆菌ST131占优势
Raphael Hermann,Annika Sobkowiak,Franziska Schuler et al.
Raphael Hermann et al.
Our study characterized 301 extended-spectrum beta-lactamases (ESBL) Escherichia coli isolates collected a tertiary hospital in Germany during a during an 18-month period starting from March 2021. All isolates were subjected to long-read wh...
Comparative genomic analysis of cyclomodulin-producing Escherichia coli strains of animal origin [0.03%]
动物源产环毒素芽孢杆菌的比较基因组分析
Domonkos Sváb,Linda Falgenhauer,Eszter Kotogán et al.
Domonkos Sváb et al.
Cytolethal distending toxin (CDT), a cyclomodulin and genotoxin produced by many Gram-negative bacteria including pathogenic Escherichia coli, disrupts the eukaryotic host cell cycle to facilitate bacterial colonization. In a survey of dair...
The substrate-binding protein DppA modulates the virulence of hypervirulent Klebsiella pneumoniae [0.03%]
底物结合蛋白DppA调节高毒力肺炎克雷伯菌的致病性
Rongping Zhu,Qingzhu Zheng,Jiacheng Qiu et al.
Rongping Zhu et al.
Hypervirulent Klebsiella pneumoniae (hvKp), one of the most significant pathogens in nosocomial infections, regulates the shift from long-term survival to pathogenicity via an intricate regulatory network. Nevertheless, the mechanism by whi...
Dehydroeffusol from Juncus effusus L. exhibits antibacterial activity against methicillin-resistant Staphylococcus aureus in vitro and in vivo [0.03%]
尖叶苔草中的脱氢effusol对耐甲氧西林金黄色葡萄球菌具有体内外抗菌活性
Shengying Lou,Wei Jin,Minyang He et al.
Shengying Lou et al.
Background: Dehydroeffusol (DHE) is a natural phenanthrene compound derived from Juncus effusus L., traditionally used for its antimicrobial properties. Despite its historical use, its antibacterial efficacy and underlyin...
Lactobacillus gasseri suppresses the Helicobacter pylori-induced expression of the proliferation-associated factors HBEGF and TGF-α in gastric host cells [0.03%]
乳酸菌肠球菌抑制Helicobacter pylori诱导的胃上皮细胞增殖相关因子HBEGF和TGF-α的表达
Tanvi Somiah,Priyodip Paul,Sarah Pilheden et al.
Tanvi Somiah et al.
To date, various probiotic lactobacilli have been tested against Helicobacter pylori. However, a detailed molecular analysis of the various signaling pathways and their associated anti-proliferative activity remains poorly understood. In ou...
Epidemiology of gonococcal arthritis in Brittany - France (EpGAr study) [0.03%]
法国布列塔尼地区淋球菌性关节炎的流行病学研究（EpGAr研究）
Valentin Lemoine,Simon Rolland,Sophie Reissier et al.
Valentin Lemoine et al.
Background: Gonococcal infections are sexually-transmitted infections (STIs), which in 0.5-3 % of cases, can progress to disseminated infections (DGI). This study aimed to characterize the epidemiology of septic arthritis...
Metabolite-responsive regulator RpiRB modulates Staphylococcus aureus pathogenicity via regulation of agr expression [0.03%]
代谢物响应调节因子RpiRB通过调控agr的表达来调节金黄色葡萄球菌毒力
Shihui Yuan,Ping Yan,Huimin Su et al.
Shihui Yuan et al.
Staphylococcus aureus is a well-known pathogenic bacterium that can produce a variety of virulence factors that cause disease in humans. RpiRB is a regulator of metabolic response, whose regulatory role in the virulence of S. aureus is larg...
Nicolas Heyer,Tobias Grebe,Andreas Schlattmann et al.
Nicolas Heyer et al.
Clostridioides difficile infection (CDI) is mediated by the cytotoxins TcdA and/or TcdB. The reliable detection of these toxins using enzyme immunoassays (EIA) could be affected by toxin stability. We assessed the toxin stability in stool s...