The substrate-binding protein DppA modulates the virulence of hypervirulent Klebsiella pneumoniae [0.03%]
底物结合蛋白DppA调节高毒力肺炎克雷伯菌的致病性
Rongping Zhu,Qingzhu Zheng,Jiacheng Qiu et al.
Rongping Zhu et al.
Hypervirulent Klebsiella pneumoniae (hvKp), one of the most significant pathogens in nosocomial infections, regulates the shift from long-term survival to pathogenicity via an intricate regulatory network. Nevertheless, the mechanism by whi...
Dehydroeffusol from Juncus effusus L. exhibits antibacterial activity against methicillin-resistant Staphylococcus aureus in vitro and in vivo [0.03%]
尖叶苔草中的脱氢effusol对耐甲氧西林金黄色葡萄球菌具有体内外抗菌活性
Shengying Lou,Wei Jin,Minyang He et al.
Shengying Lou et al.
Background: Dehydroeffusol (DHE) is a natural phenanthrene compound derived from Juncus effusus L., traditionally used for its antimicrobial properties. Despite its historical use, its antibacterial efficacy and underlyin...
Lactobacillus gasseri suppresses the Helicobacter pylori-induced expression of the proliferation-associated factors HBEGF and TGF-α in gastric host cells [0.03%]
乳酸菌肠球菌抑制Helicobacter pylori诱导的胃上皮细胞增殖相关因子HBEGF和TGF-α的表达
Tanvi Somiah,Priyodip Paul,Sarah Pilheden et al.
Tanvi Somiah et al.
To date, various probiotic lactobacilli have been tested against Helicobacter pylori. However, a detailed molecular analysis of the various signaling pathways and their associated anti-proliferative activity remains poorly understood. In ou...
Epidemiology of gonococcal arthritis in Brittany - France (EpGAr study) [0.03%]
法国布列塔尼地区淋球菌性关节炎的流行病学研究（EpGAr研究）
Valentin Lemoine,Simon Rolland,Sophie Reissier et al.
Valentin Lemoine et al.
Background: Gonococcal infections are sexually-transmitted infections (STIs), which in 0.5-3 % of cases, can progress to disseminated infections (DGI). This study aimed to characterize the epidemiology of septic arthritis...
Metabolite-responsive regulator RpiRB modulates Staphylococcus aureus pathogenicity via regulation of agr expression [0.03%]
代谢物响应调节因子RpiRB通过调控agr的表达来调节金黄色葡萄球菌毒力
Shihui Yuan,Ping Yan,Huimin Su et al.
Shihui Yuan et al.
Staphylococcus aureus is a well-known pathogenic bacterium that can produce a variety of virulence factors that cause disease in humans. RpiRB is a regulator of metabolic response, whose regulatory role in the virulence of S. aureus is larg...
Nicolas Heyer,Tobias Grebe,Andreas Schlattmann et al.
Nicolas Heyer et al.
Clostridioides difficile infection (CDI) is mediated by the cytotoxins TcdA and/or TcdB. The reliable detection of these toxins using enzyme immunoassays (EIA) could be affected by toxin stability. We assessed the toxin stability in stool s...
A pan-azole and pan-echinocandin resistant Wickerhamomyces anomalus isolate causing bloodstream infection: ERG11Y140F, K151R with copy number variation and FKS1F665S mutation [0.03%]
一种引起血流感染的对各类唑类和棘白菌素耐药的异常汉逊酵母：ERG11Y140F，K151R拷贝数变异及FKS1F665S突变
Zhengyu Luo,Yating Ning,Rongchen Dai et al.
Zhengyu Luo et al.
Fungal infections pose a growing global threat, particularly due to the emergence of multidrug-resistant pathogens. This study reports the first globally documented case of a Wickerhamomyces anomalus isolate (XN272) displaying dual high-lev...
Emergence of KL57 hypervirulent Klebsiella pneumoniae in Wuxi, China: Genomic insights into virulence plasmid evolution and blaKPC-2-bearing IncFIIK34 plasmid transmission [0.03%]
中国无锡地区KL57型高毒力肺炎克雷伯菌的出现及毒力质粒进化和blaKPC-2携带IncFIIK34型质粒传播的基因组学研究
Yutong Liu,Lin Wan,Xiong Li et al.
Yutong Liu et al.
Objective: KL57 Klebsiella pneumoniae (K. pneumoniae) is an emerging serotype with epidemiological characteristics and pathogenic mechanisms that remain incompletely understood. This study comprehensively analyzed the gen...
Emergence and genetic heterogeneity of STEC O113:H4: insights from whole-genome sequences of isolates across human and non-human sources [0.03%]
STEC O113:H4的出现和遗传异质性：来自人类及动物来源分离菌完整基因组序列的见解
Florence Crombé,Frederic Auvray,Angela H A M van Hoek et al.
Florence Crombé et al.
The increased detection of Shiga toxin-producing Escherichia coli (STEC) O113:H4 among human cases in Belgium questions the importance of this serotype as an emerging pathogen. However, detailed information focusing on serotype O113:H4 from...
Distribution and antimicrobial resistance of Acinetobacter spp. isolated from different types of clinical specimens from hospitalized patients and outpatients in Poland [0.03%]
波兰住院及门诊患者不同临床标本中不动杆菌的分离分布和耐药性分析
Tomasz Kasperski,Monika Pobiega,Monika Pomorska-Wesołowska et al.
Tomasz Kasperski et al.
Background: Acinetobacter baumannii (AB) is the most frequently isolated nosocomial pathogen, but severe infections by A. pittii, A. ursingii, and A. bereziniae are increasing. This study investigated the distribution and...