Evaluation of Aspergillus and Mucorales specific T-cells and peripheral blood mononuclear cell cytokine signatures as biomarkers of environmental mold exposure [0.03%]
评估曲霉和念珠菌属特异性T细胞及外周血单个核细胞细胞因子特征作为环境霉暴露生物标志物的价值
Lukas Page,Philipp Weis,Tobias Müller et al.
Lukas Page et al.
Mold specific T-cells have been described as a supportive biomarker to monitor invasive mycoses and mold exposure. This study comparatively evaluated frequencies and cytokine profiles of Aspergillus fumigatus and Mucorales reactive T-cells ...
Validation of a simplified in vitro Transwell® model of the alveolar surface to assess host immunity induced by different morphotypes of Aspergillus fumigatus [0.03%]
一种简化的体外Transwell模型，用于评估不同形态的烟曲霉诱导宿主免疫反应的效果
C Oliver Morton,Sebastian Wurster,Mirjam Fliesser et al.
C Oliver Morton et al.
Interactions between fungal pathogens such as Aspergillus fumigatus with host alveolar epithelium and innate immune cells are crucial in the defense against opportunistic fungal infections. In this study a simplified Transwell® system with...
Mycobacterium indicus pranii protein MIP_05962 induces Th1 cell mediated immune response in mice [0.03%]
米索尔分枝杆菌蛋白质MIP_05962诱导小鼠Th1依赖的细胞免疫反应
Ashish Sharma,Mohd Saqib,Javaid A Sheikh et al.
Ashish Sharma et al.
Utility of Mycobacterium indicus pranii (MIP) as a multistage vaccine against mycobacterial infections demands identification of its protective antigens. We explored antigenicity and immunogenicity of a candidate protein MIP_05962 that depi...
Complement depletion and Coombs positivity in pneumococcal hemolytic uremic syndrome (pnHUS). Case series and plea to revisit an old pathogenetic concept [0.03%]
肺炎链球菌溶血性尿毒症综合征(pnHUS)中的补体消耗和库姆斯阳性：病例系列及重新审视旧发病机制概念的呼吁
Martin Bitzan,Omar AlKandari,Blair Whittemore et al.
Martin Bitzan et al.
Hemolytic uremic syndrome is a rare complication of invasive pneumococcal infection (pnHUS). Its pathogenesis is poorly understood, and treatment remains controversial. The emerging role of complement in various forms of HUS warrants a new ...
Factors in the emergence of serious human infections associated with highly pathogenic strains of shiga toxin-producing Escherichia coli [0.03%]
致病性肠出血型大肠杆菌感染事件流行的因素分析
Mohamed A Karmali
Mohamed A Karmali
The appearance of highly pathogenic strains of Shiga toxin (Stx)-producingEscherichia. coli (STEC) has owed largely to the acquisition of Stx-encoding prophages by strains of E. coli that have pre-existing potential as enteric pathogens, su...
Uropathogenic Escherichia coli preferentially utilize metabolites in urine for nucleotide biosynthesis through salvage pathways [0.03%]
尿源性代谢物通过回收途径被致尿路感染的大肠杆菌优先用于核苷酸的生物合成
Jiale Ma,Xuwang Cai,Yinli Bao et al.
Jiale Ma et al.
Growth in urinary tract depends on the ability of uropathogenic E. coli to adjust metabolism in response to available nutrients, especially to synthesize metabolites that are present in urinary tract with limited concentrations. In this stu...
Emergence of an extensively drug-resistant (XDR) Streptococcus pneumoniae serotype 15A by capsular switching [0.03%]
通过荚膜转换产生的广泛耐药（XDR）肺炎链球菌血清型15A的出现
Jin Yang Baek,So Hyun Kim,Cheol-In Kang et al.
Jin Yang Baek et al.
Recently, we have identified an extensively drug-resistant (XDR) Streptococcus pneumoniae serotype 15A isolate from a patient with bacterial meningitis. It belonged to sequence type 8279 (ST8279), a clone identified as XDR serotype 11A isol...
Thioloxidoreductase HP0231 of Helicobacter pylori impacts HopQ-dependent CagA translocation [0.03%]
幽门螺杆菌半胱氨酸硫氧化还原酶HP0231影响HopQ依赖的CagA转运
Magdalena J Grzeszczuk,Katarzyna M Bocian-Ostrzycka,Anna M Banaś et al.
Magdalena J Grzeszczuk et al.
Thioloxidoreductase HP0231 of Helicobacter pylori plays essential roles in gastric colonization and related gastric pathology. Comparative proteomics and analysis of complexes between HP0231 and its protein substrates suggested that several...
Microevolution of epidemiological highly relevant non-O157 enterohemorrhagic Escherichia coli of serogroups O26 and O111 [0.03%]
与流行病学高度相关的非O157肠出血性大肠杆菌血清群O26和O111的微进化
Inga Eichhorn,Torsten Semmler,Alexander Mellmann et al.
Inga Eichhorn et al.
Enterohemorrhagic Escherichia coli (EHEC) are a cause of bloody diarrhea, hemorrhagic colitis (HC) and the potentially fatal hemolytic uremic syndrome (HUS). While O157:H7 is the dominant EHEC serotype, non-O157 EHEC have emerged as serious...
A novel mba-based Real time PCR approach for genotyping of Ureaplasma parvum validated in a cohort of Mongolian mothers and offspring [0.03%]
一种新的基于MBA的实时PCR方法对脲原体进行基因分型并在蒙古族母婴队列中得到验证
B Otgonjargal,G Batbaatar,K Pfeffer et al.
B Otgonjargal et al.
The role of Ureaplasma parvum in abnormal outcomes of human pregnancy has been discussed controversially in the past. Of the 14 known ureaplasma serovars, the Ureaplasma parvum serovars 1, 3, 6 and 14, have been found to derive from smaller...