Hospital outbreak due to Clostridium difficile ribotype 018 (RT018) in Southern Germany [0.03%]
德国南部医疗机构发生难辨梭菌018型（RT018）暴发事件
Fabian K Berger,Sabine Gfrörer,Sören L Becker et al.
Fabian K Berger et al.
Clostridium (Clostridioides) difficile is the main cause of nosocomial diarrhoea. Ribotype 018 (RT018) has been recognized as the predominant strain responsible for C. difficile infection (CDI) in Italy, whereas in most other European count...
Carriage meningococcal isolates with capsule null locus dominate among high school students in a non-endemic period, Italy, 2012-2013 [0.03%]
意大利皮埃蒙特地区高中生2012-2013学年（非流行期）奈瑟菌载体分离株以无荚膜基因型为主导
Arianna Neri,Cecilia Fazio,Luigina Ambrosio et al.
Arianna Neri et al.
Meningococcal disease incidence in Italy remains quite low in the overall population except for infants. Within a study on carriage isolates among high school students we aimed to define: i) the prevalence of carriage isolates, ii) the phen...
Biofilm development and computational screening for new putative inhibitors of a homolog of the regulatory protein BrpA in Streptococcus dysgalactiae subsp. dysgalactiae [0.03%]
黏膜形成及计算筛选新的乳球菌属血红素调节蛋白BrpA同源物抑制剂
Cinthia Alves-Barroco,Catarina Roma-Rodrigues,Natesan Balasubramanian et al.
Cinthia Alves-Barroco et al.
Streptococcus dysgalactiae subsp. dysgalactiae (SDSD), a Lancefield group C streptococci (GCS), is a frequent cause of bovine mastitis. This highly prevalent disease is the costliest in dairy industry. Adherence and biofilm production are i...
Virulence-related genes are associated with clinical and nutritional outcomes of Shigella/Enteroinvasive Escherichia coli pathotype infection in children from Brazilian semiarid region: A community case-control study [0.03%]
与巴西半干旱地区志贺菌/侵袭性大肠杆菌血清型感染的临床和营养结局相关的毒力相关基因：一项社区病例对照研究
Mariana Bona,Pedro Henrique Medeiros,Ana Karolina Santos et al.
Mariana Bona et al.
Shigella/Enteroinvasive Escherichia coli (EIEC) pathotype is a major enteropathogen associated with diarrhea and malnutrition in children from developing countries. This study aimed to correlate Shigella/EIEC virulence-related genes (VRGs) ...
Mig-14 may contribute to Salmonella enterica serovar Typhi resistance to polymyxin B by decreasing the permeability of the outer-membrane and promoting the formation of biofilm [0.03%]
Mig-14通过降低外膜通透性并促进生物被膜的形成来参与伤寒沙门氏菌耐多粘菌素B的作用
Xiumei Sheng,Weiwei Wang,Long Chen et al.
Xiumei Sheng et al.
Mig-14 is essential for Salmonella enterica serovar Typhimurium (S. Typhimurium) resistance to antimicrobial peptides, including polymyxin B (PB). However, the molecular mechanism is as yet unknown. In this study, we demonstrated that mig-1...
Alterations on growth and cell organization of Giardia intestinalis trophozoites after treatment with KH-TFMDI, a novel class III histone deacetylase inhibitor [0.03%]
新型组蛋白去乙酰化酶抑制剂KH-TFMDI对肠氨滴虫裂殖体生长及细胞结构的影响
Ana Paula R Gadelha,Bárbara Bravim,Juliana Vidal et al.
Ana Paula R Gadelha et al.
Giardia trophozoites have developed resistance mechanisms to currently available compounds, leading to treatment failures. In this context, the development of new additional agents is mandatory. Sirtuins, which are class III NAD+-dependent ...
Characterization of a novel protein of Leptospira interrogans exhibiting plasminogen, vitronectin and complement binding properties [0.03%]
表征一种新型可结合纤溶酶原、丝氨酸蛋白酶抑制剂和补体的问号钩端螺旋体蛋白
Maria F Cavenague,Aline F Teixeira,Antonio S Filho et al.
Maria F Cavenague et al.
Leptospirosis is a severe zoonosis caused by pathogenic species of the genus Leptospira. This work focuses on a hypothetical protein of unknown function, encoded by the gene LIC13259, and predicted to be a surface protein, widely distribute...
Acinetobacter baumannii outer membrane protein A induces HeLa cell autophagy via MAPK/JNK signaling pathway [0.03%]
铜绿假单胞菌外膜蛋白A通过MAPK/JNK信号传导诱导HeLa细胞自噬
Zhiyuan An,Xiaoxi Huang,Chunming Zheng et al.
Zhiyuan An et al.
Autophagy is an evolutionary conserved self-balancing process that plays an important role in maintaining cellular homeostasis via the clearance of damaged organelles and misfolded proteins. Infection-triggered autophagy specifically inhibi...
The ArlR-MgrA regulatory cascade regulates PIA-dependent and protein-mediated biofilm formation in Rbf-dependent and Rbf-independent pathways [0.03%]
ArlR-MgrA调控级联通过Rbf依赖和非依赖途径调节PIA依赖型和蛋白质介导型生物被膜的形成
Zeyu Jin,Qiu Jiang,Bo Fang et al.
Zeyu Jin et al.
The two-component system response regulator ArlR and the global regulator MgrA in Staphylococcus aureus participated in numerous biological processes including biofilm formation inhibition. Previous studies have shown that these two regulat...
Phenotypic and molecular characterization of Escherichia albertii: Further surrogates to avoid potential laboratory misidentification [0.03%]
爱德华氏菌埃伯塔亚种的表型和分子特征分析：进一步替代方案避免实验室潜在误鉴定
Atsushi Hinenoya,Hidetoshi Ichimura,Sharda Prasad Awasthi et al.
Atsushi Hinenoya et al.
Escherichia albertii is an emerging gastrointestinal pathogen, related to Escherichia coli, which can be misidentified as enteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC), due to the presence of the eae gene in E. albert...