Consequences of dosing and timing on the antibacterial effects of ADEP antibiotics [0.03%]
给药剂量和时间对ADEP抗生素抗菌效果的影响
Christian Mayer,Peter Sass,Heike Brötz-Oesterhelt
Christian Mayer
Antibiotic acyldepsipeptides (ADEPs) exert potent antibacterial activity in rodent models of bacterial infection and exceptional efficacy against persister cells of methicillin-resistant Staphylococcus aureus (MRSA). The mechanism of ADEP a...
Role of the Streptomyces spore wall synthesizing complex SSSC in differentiation of Streptomyces coelicolor A3(2) [0.03%]
红螺菌素 Streptomyces coelicolor A3(2) 分化的 SSSC 菌丝壁合成复合体的作用机制研究
B Vollmer,N Steblau,N Ladwig et al.
B Vollmer et al.
A crucial stage of the Streptomyces life cycle is the sporulation septation, a process were dozens of cross walls are synchronously formed in the aerial hyphae in a highly coordinated manner. This process includes the remodeling of the spor...
Role of α-glucan-induced oxygen species in dendritic cells and its impact in immune response against tuberculosis [0.03%]
α-葡聚糖诱导的氧自由基在树突状细胞中的作用及其对结核病免疫反应的影响
María Mercedes Romero,Alejandra Duarte,Mercedes Pastorini et al.
María Mercedes Romero et al.
With 10 million new cases and three million deaths estimated to occur yearly ̶ more than any time in history ̶ tuberculosis (TB) remains the single most widespread and deadly infectious disease. Until recently, it was thought that both la...
Christoph Mayer,Robert Maria Kluj,Maraike Mühleck et al.
Christoph Mayer et al.
The ability to recover components of their own cell wall is a common feature of bacteria. This was initially recognized in the Gram-negative bacterium Escherichia coli, which recycles about half of the peptidoglycan of its cell wall during ...
Assessing capreomycin resistance on tlyA deficient and point mutation (G695A) Mycobacterium tuberculosis strains using multi-omics analysis [0.03%]
利用多种组学分析方法评估tlyA基因缺陷和点突变(G695A)结核杆菌株的卡纳霉素耐药性
Jiao Zhao,Wenjing Wei,Huimin Yan et al.
Jiao Zhao et al.
Capreomycin (CAP), a cyclic peptide antibiotic, is considered to be an ideal second-line drug for tuberculosis (TB). However, in the past few years, the emergence of more CAP-resistant (CAPr) TB patients has limited its use. Although it has...
The multicopper oxidase of Mycobacterium tuberculosis (MmcO) exhibits ferroxidase activity and scavenges reactive oxygen species in activated THP-1 cells [0.03%]
结核分枝杆菌多铜氧化酶(MmcO)具有血红素氧还蛋白活性并能够清除活化单核细胞THP-1中的活性氧
Eyad Kinkar,Ayat Kinkar,Mazen Saleh
Eyad Kinkar
The MmcO protein of Mycobacterium tuberculosis is a membrane-associated multicopper oxidase. Its natural substrate(s) and its role in pathogenesis are not well characterized. A recent report proposes that MmcO contributes to copper resistan...
Janani Natarajan,Nidhi Singh,Doron Rapaport
Janani Natarajan
In Gram-negative bacteria, secretion of toxins ensure the survival of the bacterium. Such toxins are secreted by sophisticated multiprotein systems. The most conserved part in some of these secretion systems are components, called secretins...
Identification of two abundant Aerococcus urinae cell wall-anchored proteins [0.03%]
鉴定两种丰富的尿道葡萄球菌细胞壁锚定蛋白
Erik Senneby,Torgny Sunnerhagen,Björn Hallström et al.
Erik Senneby et al.
Aerococcus urinae is an emerging pathogen that causes urinary tract infections, bacteremia and infective endocarditis. The mechanisms through which A. urinae cause infection are largely unknown. The aims of this study were to describe the s...
Cryopreservation of the human gut microbiota: Current state and perspectives [0.03%]
人体肠道微生物群的冷冻保存：现状与展望
Daria V Smirnova,Ljubov V Zalomova,Angelika V Zagainova et al.
Daria V Smirnova et al.
The human intestinal microbiota is a complex ecosystem that consists of thousands of bacterial species that are responsible for human health and disease. The intestinal microbiota is a natural resource for production of therapeutic and prev...
Structural diversity of coiled coils in protein fibers of the bacterial cell envelope [0.03%]
细菌细胞包膜蛋白纤维中卷曲螺旋的结构多样性
Birte Hernandez Alvarez,Jens Bassler,Andrei N Lupas
Birte Hernandez Alvarez
The cell envelope of bacteria shows great diversity in architecture and composition, to a large extent due to its proteome. Proteins localized to the cell envelope, whether integrally embedded in the membrane, membrane-anchored, or peripher...