Screen for fitness and virulence factors of Francisella sp. strain W12-1067 using amoebae [0.03%]
利用变形虫筛选弗朗西斯菌W12-1067株的适应性和毒力因素
Kristin Köppen,Fan Chen,Kerstin Rydzewski et al.
Kristin Köppen et al.
Francisella tularensis is the causative agent of the human disease referred to as tularemia. Other Francisella species are known but less is understood about their virulence factors. The role of environmental amoebae in the life-cycle of Fr...
Emerging challenges of whole-genome-sequencing-powered epidemiological surveillance of globally distributed clonal groups of bacterial infections, giving Acinetobacter baumannii ST195 as an example [0.03%]
全基因组测序推动的细菌感染克隆群流行病学监测面临的新挑战——以全球传播的鲍曼不动杆菌ST195为例
Huiqiong Jia,Yan Chen,Jianfeng Wang et al.
Huiqiong Jia et al.
Whole-genome sequencing (WGS) has revolutionized the genotyping of bacterial pathogens and is expected to become the new gold standard for tracing the transmissions of bacterial infectious diseases for public health purposes. However, it is...
Molecular typing and in vitro resistance of Cryptococcus neoformans clinical isolates obtained in Germany between 2011 and 2017 [0.03%]
2011至2017年德国临床分离的新生隐球菌分子分型及体外耐药性分析
Regina Selb,Vidmante Fuchs,Barbara Graf et al.
Regina Selb et al.
Cryptococcosis is a fungal infection of the central nervous system predominantly caused by Cryptococcus neoformans in immunocompromised patients. In several countries worldwide, up to 50% of isolates show in vitro resistance to clinically u...
Rapid diagnosis of bacterial meningitis by nanopore 16S amplicon sequencing: A pilot study [0.03%]
基于纳米孔扩增子测序的细菌性脑膜炎快速诊断：一项初步研究
Jangsup Moon,Narae Kim,Tae-Joon Kim et al.
Jangsup Moon et al.
Early administration of antibiotics is crucial in the management of bacterial meningitis. Rapid pathogen identification helps to make a definite diagnosis of bacterial meningitis and enables tailored antibiotic treatment. We investigated if...
Unraveling the mechanism of peptidoglycan amidation by the bifunctional enzyme complex GatD/MurT: A comparative structural approach [0.03%]
肽聚糖酰胺化机制的解析——具有双功能酶活性的GatD/MurT复合物的比较结构研究
Erik R Nöldeke,Thilo Stehle
Erik R Nöldeke
The bacterial cell wall provides structural integrity to the cell and protects the cell from internal pressure and the external environment. During the course of the twelve-year funding period of the Collaborative Research Center 766, our w...
Unraveling the mechanism of peptidoglycan amidation by the bifunctional enzyme complex GatD/MurT: A comparative structural approach [0.03%]
解开GatD/MurT双功能酶复合物介导的肽聚糖酰胺化反应机制：结构比较研究
Erik R Nöldeke,Thilo Stehle
Erik R Nöldeke
The bacterial cell wall provides structural integrity to the cell and protects the cell from internal pressure and the external environment. During the course of the twelve-year funding period of the Collaborative Research Center 766, our w...
Environmental and cellular factors affecting the localization of T6SS proteins in Burkholderia thailandensis [0.03%]
影响Burkholderia thailandensis中T6SS蛋白定位的环境和细胞因素
Jan Lennings,Munira Makhlouf,Przemyslaw Olejnik et al.
Jan Lennings et al.
The type VI secretion system (T6SS) injects effector proteins into neighboring bacteria and host cells. Effector translocation is driven by contraction of a tubular sheath in the cytoplasm that expels an inner needle across the cell envelop...
Investigating the assembly of the bacterial type III secretion system injectisome by in vivo photocrosslinking [0.03%]
通过体内光交联研究细菌III型分泌系统的装配
Nidhi Singh,Samuel Wagner
Nidhi Singh
Virulence-associated type III secretion systems serve the injection of bacterial effector proteins into eukaryotic host cells. These effector proteins modulate host cell biology in order to promote colonization and infection, hence type III...
Function and regulation of Staphylococcus aureus wall teichoic acids and capsular polysaccharides [0.03%]
金黄色葡萄球菌壁-teichoic酸和荚膜多糖的功能及调控机制
Daniela Keinhörster,Shilpa Elizabeth George,Christopher Weidenmaier et al.
Daniela Keinhörster et al.
Staphylococcus aureus produces different secondary cell wall glycopolymers such as wall teichoic acids (WTA) and capsular polysaccharides (CP). These structures play an important role in S. aureus colonization, pathogenesis and bacterial ev...
Diversity of peptidoglycan structure-Modifications and their physiological role in resistance in antibiotic producers [0.03%]
肽聚糖结构的多样性：产生抗生素生物中对其生理作用的研究及对抗生素抗性的修饰
Sandra Unsleber,Wolfgang Wohlleben,Evi Stegmann
Sandra Unsleber
Peptidoglycan (PG) is a bacteria specific cell surface layer that ensures the bacterial shape and integrity. The two actinomycetes Amycolatopsis balhimycina and Microbispora sp. PTA-5024 are producers of PG targeting antibiotics. To prevent...