Untargeted accurate identification of highly pathogenic bacteria directly from blood culture flasks [0.03%]
直接从血培养瓶中精准鉴定高致病性细菌的非靶向准确定量方法
Erwin M Berendsen,Evgeni Levin,René Braakman et al.
Erwin M Berendsen et al.
To improve the preparedness against exposure to highly pathogenic bacteria and to anticipate the wide variety of bacteria that can cause bloodstream infections (BSIs), a safe, unbiased and highly accurate identification method was developed...
Tigecycline resistance may be associated with dysregulated response to stress in Mycobacterium abscessus [0.03%]
泰格尔cyclin耐药可能与鸟分枝杆菌复合体对压力反应失调有关
Hien Fuh Ng,Yun Fong Ngeow,Sook Fan Yap et al.
Hien Fuh Ng et al.
Previously, we characterized 7C, a laboratory-derived tigecycline-resistant mutant of Mycobacterium abscessus ATCC 19977, and found that the resistance was conferred by a mutation in MAB_3542c, which encodes an RshA-like protein. In M. tube...
Co-existence of Citrobacter freundii exacerbated Pseudomonas aeruginosa infection in vivo [0.03%]
柠檬酸杆菌体外加剧绿脓杆菌感染
Qing Peng,Lin Chen,Shuqin Zhou et al.
Qing Peng et al.
The presence of bacterial species other than the pathogen at infection site can affect the progression of a bacterial infection. Based on the fact that Citrobacter freundii can coexist during Pseudomonas aeruginosa infection, this study aim...
Over-expression of Tgs1 in Mycobacterium marinum enhances virulence in adult zebrafish [0.03%]
海洋分枝杆菌Tgs1过表达增强斑马鱼致病性
Ding-Qian Liu,Jun-Li Zhang,Zhi-Fen Pan et al.
Ding-Qian Liu et al.
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), can persist in the host for decades without causing TB symptoms and can cause a latent infection, which is an intricate challenge of current TB control. The DosR re...
Escherichia coli strains producing a novel Shiga toxin 2 subtype circulate in China [0.03%]
中国发现产新型志贺毒素2亚型的大肠杆菌菌株广泛存在
Xi Yang,Xiangning Bai,Ji Zhang et al.
Xi Yang et al.
Shiga toxin (Stx) is the key virulence factor in Shiga toxin producing Escherichia coli (STEC), which can cause diarrhea and hemorrhagic colitis with life-threatening complications. Stx comprises two toxin types, Stx1 and Stx2. Several Stx1...
Transcriptomic analysis of smooth versus rough Brucella melitensis Rev.1 vaccine strains reveals insights into virulence attenuation [0.03%]
转录组分析揭示了关于布氏菌病疫苗毒株减毒机制的新见解
Mali Salmon-Divon,David Kornspan
Mali Salmon-Divon
Brucella melitensis Rev.1 is the live attenuated Elberg-originated vaccine strain of the facultative intracellular Brucella species, and is widely used to control brucellosis in small ruminants. However, Rev.1 may cause abortions in small r...
Elicitation of Th1/Th2 related responses in mice by chitosan nanoparticles loaded with Brucella abortus malate dehydrogenase, outer membrane proteins 10 and 19 [0.03%]
负载布鲁杆菌苹果酸脱氢酶、外膜蛋白10和19的壳聚糖纳米粒对小鼠Th1/Th2相关免疫应答的诱导研究
Soojin Shim,Sang Hee Soh,Young Bin Im et al.
Soojin Shim et al.
Brucella spp. is the causative agent of brucellosis, one of the worldwide diseases. The pathogen infects humans and animals mainly through the digestive or respiratory tract. Therefore, induction of mucosal immunity is required as the first...
Sub-Inhibitory concentrations of SOS-Response inducing antibiotics stimulate integrase expression and excision of pathogenicity islands in uropathogenic Escherichia coli strain 536 [0.03%]
诱导SOS反应的抗生素亚抑菌浓度可刺激尿路致病性大肠杆菌（UPEC）536株的基因重组酶表达及毒力岛切除重组
Marco Chittò,Michael Berger,Luisa Klotz et al.
Marco Chittò et al.
Urinary tract infections are one of the most common bacterial infections and a major public health problem. The predominant causative agents are uropathogenic Escherichia coli. These strains differ from commensal E. coli by the presence of ...
Intestinal amoebiasis: 160 years of its first detection and still remains as a health problem in developing countries [0.03%]
肠阿米巴病：首次检测已经过去了160年但仍存在于发展中国家的健康问题
Julio C Carrero,Magda Reyes-López,Jesús Serrano-Luna et al.
Julio C Carrero et al.
Amoebiasis is a parasitic disease caused by Entamoeba histolytica (E. histolytica), an extracellular enteric protozoan. This infection mainly affects people from developing countries with limited hygiene conditions, where it is endemic. Inf...
Allicin, a natural antimicrobial defence substance from garlic, inhibits DNA gyrase activity in bacteria [0.03%]
大蒜中的天然抗菌物质_allicin_可抑制细菌的DNA回旋酶活性
Jana Reiter,Anna Maria Hübbers,Frank Albrecht et al.
Jana Reiter et al.
Allicin (diallylthiosulfinate) is a potent antimicrobial substance, produced by garlic tissues upon wounding as a defence against pathogens and pests. Allicin is a reactive sulfur species (RSS) that oxidizes accessible cysteines in glutathi...