Strain inheritance and neonatal gut microbiota development: A meta-analysis [0.03%]
strain遗传与新生儿肠道微生物群发育：一项荟萃分析
Daniel Podlesny,W Florian Fricke
Daniel Podlesny
As many inflammatory and metabolic disorders have been associated with structural deficits of the human gut microbiota, the principles and mechanisms that govern its initialization and development are of considerable scientific interest and...
Defence and adaptation mechanisms of the intestinal epithelium upon infection [0.03%]
肠道感染下的肠上皮防御和适应机制
Amina Iftekhar,Michael Sigal
Amina Iftekhar
The intestinal epithelium is a monolayer of polarized columnar cells that act as a border between the host and its environment and are the first line of defence against the luminal microbes. In addition to providing a physical barrier, the ...
Lymph node stromal cell subsets-Emerging specialists for tailored tissue-specific immune responses [0.03%]
淋巴结基质细胞亚群-定制的组织特异性免疫反应专家
Mangge Zou,Carolin Wiechers,Jochen Huehn
Mangge Zou
The effective priming of adaptive immune responses depends on the precise dispatching of lymphocytes and antigens into and within lymph nodes (LNs), which are strategically dispersed throughout the body. Over the past decade, a growing body...
Modeling microbe-host interaction in the pathogenesis of Crohn's disease [0.03%]
建模宿主与微生物的交互作用以研究克罗恩病的发病机制
Mohamed Ahmed,Amira Metwaly,Dirk Haller
Mohamed Ahmed
Alterations in the gut microbiota structure and function are thought to play an important role in the pathogenesis of Crohn's disease (CD). The rapid advancement of high-throughput sequencing technologies led to the identification of microb...
J Christian Pérez
J Christian Pérez
It is becoming increasingly clear that fungi are important components of the gut microbiota. Fungi residing in the human intestine, for example, elicit the induction of T helper 17 cells, which are central orchestrators of protective immune...
The role of the blood group-related glycosyltransferases FUT2 and B4GALNT2 in susceptibility to infectious disease [0.03%]
血型相关糖基转移酶FUT2和B4GALNT2在易感感染性疾病中的作用
Alibek Galeev,Abdulhadi Suwandi,Aleksa Cepic et al.
Alibek Galeev et al.
The glycosylation profile of the gastrointestinal tract is an important factor mediating host-microbe interactions. Variation in these glycan structures is often mediated by blood group-related glycosyltransferases, and can lead to wide-ran...
Interferons at the crossroad of cell death pathways during gastrointestinal inflammation and infection [0.03%]
干扰素在胃肠炎症和感染过程中介导细胞死亡途径的交汇点的作用
Iris Stolzer,Barbara Ruder,Markus F Neurath et al.
Iris Stolzer et al.
Interferons (IFNs) are pleiotropic immune-modulatory cytokines that are well known for their essential role in host defense against viruses, bacteria, and other pathogenic microorganisms. They can exert both, protective or destructive funct...
Gerhard Liebisch,Johannes Plagge,Marcus Höring et al.
Gerhard Liebisch et al.
Gut microbiota significantly influence the plasma and liver lipidome. An interconnecting metabolite is acetate generated after degradation and fermentation of dietary fiber by the gut microbiota, which is metabolized in the liver into longe...
Recognition of food antigens by the mucosal and systemic immune system: Consequences for intestinal development and homeostasis [0.03%]
肠黏膜及系统性免疫识别食品抗原及其对肠道发育和稳态的影响
Yasmina Rodriguez-Sillke,Alexander Visekruna,Rainer Glauben et al.
Yasmina Rodriguez-Sillke et al.
The impact of nutrition on systemic and intestinal immune responses remains controversially discussed and yet not fully understood. The majority of studies investigating the effects of dietary antigens focused to understand how local and sy...
Monitoring and contamination incidence of gnotobiotic experiments performed in microisolator cages [0.03%]
无菌动物屏障系统层流架内微隔离器中无菌鼠监测及污染调查
Marijana Basic,Silvia Bolsega,Anna Smoczek et al.
Marijana Basic et al.
With the increased interest in the microbiome research, gnotobiotic animals and techniques emerged again as valuable tools to investigate functional effects of host-microbe and microbe-microbe interactions. The increased demand for gnotobio...