Longitudinal relationship between the gut microbiota variation and diversity and gut graft-versus-host disease (GVHD) following pediatric allogeneic hematopoietic cell transplantation (HCT) - Case series [0.03%]
儿童异基因造血细胞移植后肠道移植物抗宿主病的纵向变化及其与肠道微生物群多样性的关系-病例系列研究
Ashley N Gray,Nicole H Tobin,Theodore B Moore et al.
Ashley N Gray et al.
Allogeneic Hematopoietic Cell Transplantation (HCT) offers children with life-threatening diseases a chance at survival. Complications from graft-versus-host disease (GVHD, Stages 0-4) represent a significant cause of morbidity and mortalit...
Plasmodium falciparum rhoptry neck protein 4 has conserved regions mediating interactions with receptors on human erythrocytes and hepatocyte membrane [0.03%]
恶性疟原虫顶体素颈蛋白4与人红细胞和肝细胞膜受体相互作用的保守结构域
Fredy A Pulido-Quevedo,Gabriela Arévalo-Pinzón,Jeimmy J Castañeda-Ramírez et al.
Fredy A Pulido-Quevedo et al.
Plasmodium falciparum-related malaria represents a serious worldwide public health problem due to its high mortality rates. P. falciparum expresses rhoptry neck protein 4 (PfRON4) in merozoite and sporozoite rhoptries, it participates in ti...
Antibacterial and antibiofilm efficacy of repurposing drug hexestrol against methicillin-resistant Staphylococcus aureus [0.03%]
氯烯雌酚对耐甲氧西林金黄色葡萄球菌抗菌及抑制生物被膜形成的功效评估
Shasha Liu,Pengfei She,Zehao Li et al.
Shasha Liu et al.
There has been an explosion in the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) because of the indiscriminate use of antibiotics. In this study, we repurposed hexestrol (HXS) as an antibacterial agent to fight planktonic...
Mechanisms of folate metabolism-related substances affecting Staphylococcus aureus infection [0.03%]
叶酸代谢相关物质影响金黄色葡萄球菌感染的机制研究
Qiyuan Jin,Xiaolu Xie,Yaxuan Zhai et al.
Qiyuan Jin et al.
Staphylococcus aureus (S. aureus) is one of the critical clinical pathogens which can cause multiple diseases ranging from skin infections to fatal sepsis. S. aureus is generally considered to be an extracellular pathogen. However, more and...
Anti-inflammatory effect of chlorogenic acid in Klebsiella pneumoniae-induced pneumonia by inactivating the p38MAPK pathway [0.03%]
氯ogenic酸通过抑制p38MAPK通路抑制肺炎克雷伯菌诱导的肺炎的炎症反应
Yizhe Zhang,Chaoyin Zhu,Hongjun Zhao et al.
Yizhe Zhang et al.
Introduction: Pneumonia is an inflammation-related respiratory infection and chlorogenic acid (CGA) possesses a wide variety of bioactive properties, such as anti-inflammation and anti-bacteria. ...
Pretreatment with 3-methyladenine ameliorated Pseudomonas aeruginosa-induced acute pneumonia by inhibiting cell death of neutrophils in a mouse infection model [0.03%]
氨甲酰腺嘌呤预处理通过抑制中性粒细胞坏死改善绿脓杆菌所致小鼠急性肺炎
Lei Yue,Han Cao,Jialong Qi et al.
Lei Yue et al.
Pseudomonas aeruginosa is one of the leading causes of nosocomial infections worldwide. Clinical isolates that are resistant to multiple antimicrobials make it intractable. The interactions between P. aeruginosa and host cell death have mul...
Does pre-incubation in selective-enrichment media improve the detection of diarrheagenic Escherichia coli using the RIDA®GENE PCR? [0.03%]
选择性增菌培养预孵育是否可改善腹泻致病大肠杆菌的PCR检测效果？
Neele J Froböse,Ioana D Olaru,Julia Sophie Schneider et al.
Neele J Froböse et al.
We aimed to investigate whether a selective pre-PCR enrichment step improves test performance of RIDA®GENE EHEC/EPEC to detect diarrheagenic Escherichia coli from stool samples. Each of the 250 stool samples was analyzed for the presence o...
Comparative analysis of outer membrane vesicles from uropathogenic Escherichia coli reveal the role of aromatic amino acids synthesis proteins in motility [0.03%]
尿路致病大肠杆菌外膜囊泡的比较分析揭示芳香族氨基酸合成蛋白在运动性中的作用
LiangZhe Liu,Carmen Oi Kwan Law,Qichang Nie et al.
LiangZhe Liu et al.
Uropathogenic Escherichia coli (UPEC) are causative agent that causes urinary tract infections (UTIs) and the recent emergence of multidrug resistance (MDR) of UPEC increases the burden on the community. Recent studies of bacterial outer me...
Chlamydia psittaci inhibits apoptosis of human neutrophils by activating P2X7 receptor expression [0.03%]
鸡毒支原体通过激活P2X7受体表达抑制人中性粒细胞凋亡
Zhangping He,Chuan Wang,Jianye Wang et al.
Zhangping He et al.
This study tested the hypothesis that Chlamydia psittaci (C. psittaci) survives and multiplies in human neutrophils by activating P2X7, a nonselective cationic channel receptor expressed constitutively on the surface of these cells. Finding...
Nanopore 16S amplicon sequencing enables rapid detection of pathogen in knee periprosthetic joint infection [0.03%]
纳米孔16S扩增子测序可在人工膝关节周围感染中快速检测病原体
Hyuk-Soo Han,Du Hyun Ro,Jeehyeok Chung et al.
Hyuk-Soo Han et al.
Objectives: We investigated whether nanopore 16S amplicon sequencing is capable of bacterial identification in patients with knee prosthetic joint infection (PJI), and we compared its efficacy with conventional culture st...