Axel A Brakhage,Uwe Gross,Joachim Morschhäuser
Axel A Brakhage
Host-pathogen interactions and virulence-associated genes during Candida albicans oral infections [0.03%]
白色念珠菌口腔感染过程中的宿主病原相互作用及致病相关基因研究
Ronny Martin,Betty Wächtler,Martin Schaller et al.
Ronny Martin et al.
Oral infections with Candida albicans are very common diseases in even only mildly immunocompromised patients. By using genome-wide microarrays, in vitro infection models and samples from patients with pseudomembranous candidiasis, several ...
Daniela Albrecht,Olaf Kniemeyer,Franziska Mech et al.
Daniela Albrecht et al.
Pathogenicity of Aspergillus fumigatus is multifactorial. Thus, global studies are essential for the understanding of the infection process. Therefore, a data warehouse was established where genome sequence, transcriptome and proteome data ...
Joachim F Ernst,Jesus Pla
Joachim F Ernst
In fungi, the cell wall is a scaffold, an armor and an environmental gate. Sugar polymers including protein-O- or N-linked glycosyl chains or polysaccharides such as glucan or chitin are essential components to maintain cell wall functions....
Nitrogen regulation of morphogenesis and protease secretion in Candida albicans [0.03%]
氮调节白色念珠菌的形态转变和蛋白酶分泌
Joachim Morschhäuser
Joachim Morschhäuser
In the pathogenic yeast Candida albicans, nitrogen availability regulates phenotypes that contribute to the virulence of the fungus, including filamentous growth and protease secretion. Under limiting nitrogen conditions, the ammonium perme...
Michael Ok,Hermann Einsele,Juergen Loeffler
Michael Ok
Invasive aspergillosis mostly caused by the opportunistic mould Aspergillus fumigatus is characterized by high morbidity and mortality in risk group patients. Several ethno-pathological factors promote the development and the course of this...
Nutrient acquisition by pathogenic fungi: nutrient availability, pathway regulation, and differences in substrate utilization [0.03%]
致病真菌的营养获取：营养供应、途径调控和底物利用差异
Christian B Fleck,Felicitas Schöbel,Matthias Brock
Christian B Fleck
All pathogenic microorganisms have in common that they need to feed on nutrients available from their host. Therefore, the specific interruption of metabolic pathways is a promising approach which could lead to the discovery of new antimicr...
The parasitophorous vacuole of Encephalitozoon cuniculi: biogenesis and characteristics of the host cell-pathogen interface [0.03%]
恩氏乳鼠脑隐球菌寄生泡：宿主细胞病原界面上的生物发生和特性
Wolfgang Bohne,Karin Böttcher,Uwe Gross
Wolfgang Bohne
Microsporidia are obligate intracellular fungal pathogens of increasing importance in immunocompromised patients. They have developed a unique invasion mechanism, which is based on the explosive discharge of a hollow tubulus, the so-called ...
Interaction of the mucosal barrier with accessory immune cells during fungal infection [0.03%]
真菌感染过程中粘膜屏障与辅助性免疫细胞的相互作用
Günther Weindl,Jeanette Wagener,Martin Schaller
Günther Weindl
The mucosal epithelium is of central importance in host defence and immune surveillance, as it is the primary cell layer that initially encounters environmental microorganisms. Induction of antifungal innate immune responses depends on reco...
The influence of SaeRS and σ(B) on the expression of superantigens in different Staphylococcus aureus isolates [0.03%]
SaesR和σ(B)对不同金黄色葡萄球菌分离株超级抗原表达的影响分析
Kathrin Kusch,Kirsten Hanke,Silva Holtfreter et al.
Kathrin Kusch et al.
Staphylococcus aureus is a major human pathogen. Superantigens (SAg) are important virulence factors in S. aureus, but the regulation of SAg gene expression is largely unknown. Using 2 sequenced S. aureus strains (COL and Newman) and 4 clin...