Investigating Ultrafiltration Membranes and Operation Modes for Improved Lentiviral Vector Processing [0.03%]
用于改进 lentiviral 载体生产的超滤膜与操作模式的研究
Jennifer J Labisch,Maria Evangelopoulou,Tobias Schleuß et al.
Jennifer J Labisch et al.
The demand for lentiviral vectors (LVs) as tools for ex vivo gene therapies is ever-increasing. Despite their promising applications, challenges in LV production remain largely due to the fragile envelope, which challenges the maintenance o...
Raman-Enabled Predictions of Protein Content and Metabolites in Biopharmaceutical Saccharomyces cerevisiae Fermentations [0.03%]
基于拉曼预测生物制药酿酒酵母发酵蛋白含量及代谢物
Jeppe Hagedorn,Guilherme Ramos,Miguel Ressurreição et al.
Jeppe Hagedorn et al.
Raman spectroscopy, a robust and non-invasive analytical method, has demonstrated significant potential for monitoring biopharmaceutical production processes. Its ability to provide detailed information about molecular vibrations makes it i...
In situ Product Recovery of Microbially Synthesized Ethyl Acetate from the Exhaust Gas of a Bioreactor by Membrane Technology [0.03%]
膜技术用于生物反应器排放气中微生物合成乙酸乙酯的原位回收
Andreas Hoffmann,Alexander Franz,Christian Löser et al.
Andreas Hoffmann et al.
Ethyl acetate is at present exclusively produced from fossil resources. Microbial synthesis of this ester from sugar-rich waste as an alternative is an aerobic process. Ethyl acetate is highly volatile and therefore stripped with the exhaus...
Mechanical Microvibration Device Enhancing Immunohistochemistry Efficiency [0.03%]
一种提高免疫组化效率的机械微振装置
Weifeng Zhang,Jirui Li,Fengshan Xie et al.
Weifeng Zhang et al.
Immunohistochemistry (IHC) is a widely used technique in diagnostic pathology and biomedical research, but there is still a need to shorten the operation process and reduce the cost of antibodies. This study aims to assess a novel IHC techn...
Identification of Plant Peroxidases Catalyzing the Degradation of Fluorinated Aromatics Using a Peroxidase Library Approach [0.03%]
基于过氧化物酶库筛选降解含氟芳香化合物植物过氧化酶
Ashton Ware,Sally Hess,David Gligor et al.
Ashton Ware et al.
In this work, the degradation of mono- and polyfluorinated phenolic compounds was demonstrated by a series of crude plant peroxidases, including horseradish root (HRP) and six members of the Cucurbita genus. Highly active samples were ident...
Microbial Squalene: A Sustainable Alternative for the Cosmetics and Pharmaceutical Industry - A Review [0.03%]
微生物角鲨烯：化妆品及制药业中的一种可持续替代品-综述文章
Saseendran Shalu,Panam Kunnel Raveendranathan Karthikanath,Vinoth Kumar Vaidyanathan et al.
Saseendran Shalu et al.
Squalene is a natural triterpenoid and a biosynthetic precursor of steroids and hopanoids in microorganisms, plants, humans, and other animals. Squalene has exceptional properties, such as its antioxidant activity, a high penetrability of t...
Stability of a Mutualistic Escherichia coli Co-Culture During Violacein Production Depends on the Kind of Carbon Source [0.03%]
紫罗素生产过程中互生型大肠杆菌共培养体系的稳定性取决于碳源种类
Simon Schick,Tobias Müller,Ralf Takors et al.
Simon Schick et al.
The L-tryptophan-derived purple pigment violacein (VIO) is produced in recombinant bacteria and studied for its versatile applications. Microbial synthetic co-cultures are gaining more importance as efficient factories for synthesizing high...
Fungal Enzymes for Saccharification of Gamma-Valerolactone-Pretreated White Birch Wood: Optimization of the Production of Talaromyces amestolkiae Cellulolytic Cocktail [0.03%]
提高产木霉菌Amestoekiensis复合 cellulase 酶制剂的发酵水平以降解 γ-戊内酯预处理白杨木质纤维素中的碳水化合物成分
Laura I de Eugenio,Isabel de la Torre,Felipe de Salas et al.
Laura I de Eugenio et al.
Lignocellulosic biomass, the most abundant natural resource on earth, can be used for cellulosic ethanol production but requires a pretreatment to improve enzyme access to the polymeric sugars while obtaining value from the other components...
Improving Downstream Process Related Manufacturability Based on Protein Engineering-A Feasibility Study [0.03%]
基于蛋白质工程的下游工艺制造可行性的研究
Florian Capito,Ting Hin Wong,Christine Faust et al.
Florian Capito et al.
While bioactivity and a favorable safety profile for biotherapeutics is of utmost importance, manufacturability is also worth of consideration to ease the manufacturing process. Manufacturability in the scientific literature is mostly relat...
Editing Streptomyces genome using target AID system fused with UGI-degradation tag [0.03%]
利用融合UGI降解标签的目标AID系统编辑链霉菌基因组
Pamella Apriliana,Prihardi Kahar,Norimasa Kashiwagi et al.
Pamella Apriliana et al.
The utilization of Streptomyces as a microbial chassis for developing innovative drugs and medicinal compounds showcases its capability to produce bioactive natural substances. Recent focus on the clustered regularly interspaced short palin...