Optimized Bioconversion of Naringenin to Hesperetin in Escherichia coli With Halide Methyltransferase-Mediated S-Adenosylmethionine Regeneration [0.03%]
基于卤素甲基转移酶介导的S-腺苷甲硫氨酸再生的橙皮素合成菌株构建与优化
Maik Wildhagen,Nina Malke,Qimin Wang et al.
Maik Wildhagen et al.
Hesperetin is a bioactive flavonoid with potential applications in pharmaceuticals and nutraceuticals, yet its low natural abundance limits commercial use. In this study, a two-step whole-cell bioconversion process was developed for the mic...
The Impact of Fungal Developmental Structures on Mechanical Properties of Mycelial Materials [0.03%]
菌丝体材料的机械性能受其真菌发育结构的影响
Kelsey Gray,Harley Edwards,Alexander G Doan et al.
Kelsey Gray et al.
This study explores how suppressing asexual development in Aspergillus nidulans enhances the mechanical properties of mycelial materials. Using four aconidial mutants (∆brlA, ∆flbA, ∆fluG, and fadAG42R ) lacking asexual development and a...
Progressive Cavity Pumps-A Comparison of New Technology for Gradient Bioprinting to Existing Extrusion Methods [0.03%]
渐进式腔室泵-梯度生物打印新技术与现有挤出方法的比较
Franz Moser,Shiva Rahmani,Tomasz Jungst
Franz Moser
Extrusion-based Bioprinting is a key technology in biofabrication, yet the choice of extrusion method is often limited to established techniques built into most bioprinters, limiting the print fidelity and more demanding applications like p...
Careful CO Addition Enhances Autotrophic d-Lactate Formation With Engineered Acetobacterium woodii [0.03%]
谨慎添加CO促进Wood氏醋酸杆菌合成d-型乳酸
Anna Stock,Inka Sotzeck,Kira Baur et al.
Anna Stock et al.
The acetogen A. woodii efficiently converts CO2 and H2 to acetate. Metabolic engineering enabled the autotrophic production of non-native products, for example, d-lactate from CO2 by overexpression of d-lactate dehydrogenase from Leuconosto...
Process Systems Engineering in Precision Medicine: Opportunities in Autologous CAR-T Therapy [0.03%]
精准医学中的过程系统工程在同种自体CAR-T治疗中的机遇
B Wayne Bequette
B Wayne Bequette
Autologous chimeric antigen receptor (CAR)-T therapies have given hope to many cancer patients whose other lines of treatment have failed. Unfortunately, limited manufacturing capability has resulted in many patients dying while on a waitli...
What Is a Biosensor?-A Terminological Guide From Biomolecular Recognition to Bioindicators [0.03%]
什么是生物传感器——从生物分子识别到生物指示物的术语指南
Tim E Weber,Anna Fritschen,Menno W J Prins et al.
Tim E Weber et al.
Biosensors are an integral part of modern medicine, are used in basic research, and are increasingly used by consumers as point-of-care and wearable devices. Meanwhile, the underlying technological approaches are rapidly expanding, includin...
Synergistic Combination of Additive One- and Two-Photon Polymerization Printing Methods to Fabricate 3D Microstructured Perfusable Angiogenesis-on-a-Chip Systems [0.03%]
结合添加型单光子和双光子聚合打印方法构建具有三维微结构的片上血管化系统
Daria Sokoliuk,Rizlene Bouhaya,Peter Haeger et al.
Daria Sokoliuk et al.
Tissue engineering, and in particular the development of organ-on-a-chip (OOC) models, holds significant promise for advancing personalized medicine and reducing the use of animal models. The integration of microfluidics and advanced biomat...
Investigation of Methacryloyl-Modified Gelatin-Based Hydrogels for Inkjet-Printed Biosensors and Their Adherence to Polyethylene Terephthalate and Oriented Polypropylene Substrates [0.03%]
用于喷墨生物传感器的甲基丙烯酰胺修饰明胶基水凝胶及其在聚对苯二甲酸乙二醇酯和取向聚丙烯基底上的粘附性研究
Caroline M Trust,Regina M Lehmann,Sarah Schmidt et al.
Caroline M Trust et al.
The COVID-19 pandemic has highlighted the need for rapid, simple, and cost-effective point-of-care testing (POCT) methods for pathogen detection. Hydrogel-based biosensing has emerged as an increasingly popular approach, offering advantages...
Exploring Ectoine Production From Methanol, Formate, and Electrochemically Produced Formate by Methyloligella halotolerans [0.03%]
利用甲醇、甲酸和电化学产生的甲酸生产甲基四肽素耐盐菌ectoine的研究
Aykut Kas,Paniz Izadi,Claudius Lenz et al.
Aykut Kas et al.
Microbial synthesis using renewable C1-carbon sources like electrochemically produced formate (e-formate) represents a promising approach for climate-neutral chemical production. This study investigates formate utilization for ectoine biosy...
Combination of Extrusion and Drop-on-Demand Bioprinting in One Process Enables the Local Placement of Cells or Signaling Factors Into (Bio) Printed Hydrogel Structures [0.03%]
基于挤出和按需滴加的混合生物打印技术在一次成形工艺中实现细胞或信号因子向水凝胶结构中的局部引入
Finn Dani,Nieves Cubo-Matteo,Leonie Schlicht et al.
Finn Dani et al.
Combining the volumetric fabrication of hydrogel constructs using extrusion bioprinting with highly precise drop-on-demand (DoD) bioprinting offers exciting opportunities in biofabrication. This technical report presents a technique in whic...