Comparative genome analysis of carbapenemase-producing Pseudomonas aeruginosa: gene diversity, clonal distribution, and genome dynamics [0.03%]
碳青霉烯耐药铜绿假单胞菌的基因组多样性、克隆分布和基因组动态的比较基因组分析
Narjes Noori Goodarzi,Farzad Badmasti
Narjes Noori Goodarzi
Carbapenem-resistant Pseudomonas aeruginosa (CRPA) represents a major health threat due to its extensive resistance to last‑resort antibiotics. Although carbapenemase determinants are key drivers of global CRPA dissemination, comprehensive...
Comparative Study
Molecular genetics and genomics : MGG. 2026 Jun 3;301(1):129. DOI:10.1007/s00438-026-02453-9 2026
RNA-binding protein hnRNPD induces epithelial-mesenchymal transition in Wilms' tumor via facilitating MAP4K4 mRNA stability [0.03%]
RNA结合蛋白hnRNPD通过促进MAP4K4 mRNA稳定性诱导肾母细胞瘤上皮间质转化
Gang Li,Man Liao,Haibin Bao et al.
Gang Li et al.
Wilms' tumor (WT) is one of the most common pediatric abdominal malignancies. The RNA-binding protein heterogeneous nuclear ribonucleoprotein D (hnRNPD) is related to cancer progression through regulating target mRNA stability. Nonetheless,...
Therapeutic target exploration of Shugan Jianpi formula in liver fibrosis: an integrated lncRNA-mRNA co-expression network analysis [0.03%]
疏肝健脾方治疗肝纤维化的作用靶点探索：整合长链非编码RNA-信使RNA共表达网络分析方法研究
Kaiqiang Wan,Qiong Zhou,Ruirui Feng et al.
Kaiqiang Wan et al.
Shugan Jianpi Formula (SGJPF), a traditional Chinese herbal formulation, has been clinically used for decades in the management of various chronic liver diseases, including liver fibrosis (LF). Previous studies have demonstrated the efficac...
Berberine impedes the DNA damage repair to inhibit colorectal cancer by regulating the SOX17/TCF4/PIM3 axis [0.03%]
巴马汀通过调节SOX17/TCF4/PIM3轴抑制结直肠癌中DNA损伤修复
Fan Hu,Wei Wang,Mei Li et al.
Fan Hu et al.
High levels of DNA damage repair (DDR) can promote the survival, immune evasion, and drug resistance of colorectal cancer (CRC) cells, consequently facilitating the advancement of CRC. This study was designed to investigate the inhibitory e...
The causality between physical activity and gestational diabetes mellitus: a Mendelian randomization study [0.03%]
运动与妊娠期糖尿病病因关系的孟德尔随机化研究
Xiaoyan Ma,Yanqiu Liu,Xia Xu et al.
Xiaoyan Ma et al.
Although observational research shows that physical activity and sedentary behavior are associated with the risk of gestational diabetes mellitus (GDM), lipid, and body mass index (BMI), their causal direction and potential mediating mechan...
Targeting KIF18B overcomes oxaliplatin resistance in esophageal squamous cell carcinoma via suppression of the ATR/CHK1 axis [0.03%]
靶向KIF18B通过抑制ATR/CHK1轴克服顺铂耐药性以治疗食管鳞状细胞癌
Wei Liu,Qianru Wang,Xiao Tan et al.
Wei Liu et al.
Esophageal squamous cell carcinoma (ESCC) is aggressive with poor prognosis, frequently driven by chemotherapy resistance. Kinesin family member 18B (KIF18B) is implicated in tumor progression, but its role in ESCC chemoresistance remains u...
Genome-wide identification, in-silico characterization, and expression analysis of polygalacturonases in different fungal species [0.03%]
不同真菌种类中opolygalacturons酶的全基因组鉴定、计算机表征及表达分析
Laiba Amin,Imran Zafar,Adil Jamal et al.
Laiba Amin et al.
Polygalacturonases (PGs) are key enzymes that hydrolyze pectin, a complex polysaccharide in plant cell walls, with essential roles in biological processes and industrial applications. This study presents a comprehensive genome-wide identifi...
UCMSC-derived exosomal circDLGAP4 enhances HFF-1 cell proliferation and migration by promoting ZNF217 promoter H3K27 acetylation [0.03%]
UCMSC来源的外泌体circDLGAP4通过促进ZNF217启动子H3K27乙酰化增强HFF-1细胞增殖和迁移
Yun-Lei Ma,Jia Fu,Yao-Xue Zhang et al.
Yun-Lei Ma et al.
Umbilical cord mesenchymal stem cells (UCMSCs) have been shown to actively participate in diabetic foot ulcer (DFU) wound healing. The human foreskin fibroblast-1 (HFF-1) cell line is a crucial and widely used in vitro model for fundamental...
FAM72A is associated with lung cancer proliferation and migration via the NF‑κB signaling pathway [0.03%]
FAM72A通过NF‑κB信号通路与肺癌增殖和迁移相关联
Qinhua Gu,Qibin Shen,Tiancheng Liu et al.
Qinhua Gu et al.
Lung cancer remains the leading cause of cancer-related deaths worldwide. While the Family with sequence similarity 72 member A (FAM72A) gene has been implicated in various cancers, its role in lung cancer is yet to be determined. This stud...
Integrated transcriptomic and metabolomic investigation reveals that graphene oxide reduces nicosulfuron detriment in sweet corn [0.03%]
集成转录组和代谢组学研究发现氧化石墨烯可减轻甜玉米 nicosulfuron 伤害
Yanli Wang,Xuemei Zhong,Meng Zhang et al.
Yanli Wang et al.
Nicosulfuron (NIF) stress poses a significant constraint on sweet corn production. Graphene oxide (GO), as an environmentally friendly nanomaterial, serves as a safe agent to enhance crop stress resistance. However, the molecular mechanisms...